Essentials of Stem Cell Biology book cover

Essentials of Stem Cell Biology

First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.

Audience
researchers, grad students, and professionals working with human stem cells in biology, tissue engineering, genetics, cancer research, virology, immunology, and biotechnology

Hardbound, 712 Pages

Published: October 2013

Imprint: Academic Press

ISBN: 978-0-12-409503-8

Contents

  • FOREWORD
    Why Stem Cell Research?
    A New Path ?{ Induced Pluripotent Stem Cells
    Embryonic Stem Cells Versus Adult Stem Cells
    'Stemness': Definitions, Criteria and Standards
    PART ONE: INTRODUCTION TO STEM CELLS
    1. Present Perspective and Future Challenges
    2. Embryonic Stem Cells in Perspective
    3. The Development of Epithelial Stem Cell Concepts
    4. The Advent of Direct Reprogramming
    5. Clinical Translation of Stem Cells
    PART TWO: BASIC BIOLOGY/MECHANISMS
    6. Molecular Basis of Pluripotency
    7. Stem Cell Niches
    8. Mechanisms of Stem Cell Self-Renewal
    9. Cell Cycle Regulators in Stem Cells
    10. Epigenetic Mechanisms of Cellular Memory
    11. Cell Fusion and the Differentiated State
    12. How Cells Change Their Phenotype
    PART THREE: TISSUE AND ORGAN DEVELOPMENT
    13. Differentiation in Early Development
    14. Primordial Germ Cells in Mouse and Human
    15. Stem Cells in Extraembryonic Lineages
    16. Amniotic Fluid Derived Pluripotent Cells
    17. Cord Blood Stem Cells
    18. Neurogenesis in the Vertebrate Embryo
    19. The Nervous System
    20. Neuronal Progenitors in the Adult Brain
    21. Sensory Epithelium of the Eye and Ear
    22. Epithelial Skin Stem Cells
    23. The Ontogeny of the Hematopoietic System
    24. Hematopoietic Stem Cells
    25. Red Blood Cells
    26. Cell Differentiation in the Skeleton
    27. Vascular Progenitor Cells
    28. Multipotent Adult Progenitor Cells
    29. Mesenchymal Stem Cells
    30. Skeletal Muscle Stem Cells
    31. Stem Cells and the Regenerating Heart
    32. Potential of ES Cell Differentiation Culture for Vascular Biology
    33. Cell Lineages and Stem Cells in the Kidney
    34. Adult Liver Stem Cells
    35. Pancreatic Stem Cells
    36. Stem Cells in the Gastrointestinal Tract
    37. Stem Cells in the Lung
    PART FOUR: METHODS
    38. Generation of Induced Pluripotent Stem Cells
    39. Characteristics and Characterization of Pluripotent Stem Cells
    40. Isolation and Maintenance of Murine Embryonic Stem Cells
    41. Isolation, Characterization, and Maintenance of Primate ES Cells
    42. Approaches for Derivation and Maintenance of Human ES Cells: Detailed Procedures and Alternatives
    43. Derivation and Differentiation of Human EG Cells
    44. Growth Factors & the Serum-Free Culture of Human Pluripotent Stem Cells
    45. Feeder-Free Culture
    46. Genetic Manipulation of Human Embryonic Stem Cells
    47. Homologous Recombination in Human Embryonic Stem Cells
    48. Surface Antigen Markers
    49. Lineage Marking
    50. Genomic Reprogramming
    51. Isolation and Characterization of Hematopoietic Stem Cells
    52. Microarray Analysis of Stem Cells and Differentiation
    53. Zebrafish and Stem Cell Research
    PART FIVE: APPLICATIONS
    54. Cancer Stem Cells
    55. Neural Stem Cells: Therapeutic Applications in Neurodegenerative Diseases
    56. Spinal Cord Injury
    57. Use of Embryonic Stem Cells to Treat Heart Disease
    58. Insulin-Producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes
    59. Burns and Skin Ulcers 978-0-12-370465-8
    60. Stem Cells and Heart Disease
    61. Stem Cells for the Treatment of Muscular Dystropy
    62. Skin Regeneration
    63. Orthopaedic Applications of Stem Cells
    64. Embryonic Stem Cells in Tissue Engineering
    65. Adult Stem Cells in Tissue Engineering
    66. Stem Cell Gene Therapy
    PART SIX: REGULATION AND ETHICS
    67. Ethical Considerations
    68. Religious Considerations
    69. Regulatory Considerations
    70. It's Not About Curiosity, It's About Cures
    Epilogue: Concluding Statement

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