Essentials of Genomic and Personalized Medicine book cover

Essentials of Genomic and Personalized Medicine

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine.

Audience
general practitioners, specialists, and students across medical disciplines, research professionals in human genetics/genomics, oncology, neuroscience, gene therapy, molecular medicine, and related areas

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Published: September 2009

Imprint: Academic Press

ISBN: 978-0-12-374934-5

Contents

  • 1 Introduction

     Section 1 - Basics
    2 Organization, Variation and Expression of the Human Genome
    3 DNA Sequencing for the Detection  of Human Genome Variation
    4 Genome-Wide Association Studies and Genotyping Technologies
    5 Copy Number Variation and Human Health
    6 DNA Methylation Analysis: Providing New Insight into Human Disease
    7 DNA Microarrays in Biological Diversity and Patient Care
    8 Proteomics: The Deciphering of the Functional Genome
    9 Comprehensive Metabolic Analysis for Understanding Disease

     Section 2 - Informatics
    10 Bioinformatic and Computational Analysis for Genomic Medicine
    11 Systems Biology and Systems Medicine
    12 Electronic Medical Records in Genomic Medicine Practice and Research
    13 Health Information Retrieval for Consumers

     Section 3 - Translational
    14 Genomics to Health:  Challenges and Opportunities
    15 Pharmacogenetics and Pharmacogenomics
    16 Clinical Implementation of Translational Genomics
    17 The Role of Genomics in Enabling Prospective Health
    18 From Sequence to Genomic Medicine: Genome Policy Considerations
    19 Federal Regulation of Genomic Medicine
    20 Economic Issues and Genomic Medicine
    21 Public Health Genomics

     Section 4 - Clinical (Cardiology)
    22 Hypertension
    23 Lipiprotein Disorders
    24 Myocardial Infarction
    25 Acute Coronary Syndromes
    26 Heart Failure in the Era of Genomic Medicine
    27 Genomic Assessment of Cardiac Transplant Rejection
    28 Hypertrophic Cardiomyopathy
    29 Arrhythmias
    30 Genetics and Genomics in the Management of Hemostasis & Thrombosis
    31 Genomics of Congenital Heart Disease

     Section 5 - Clinical (Oncology)
    32 Genomics in the Management of Lymphomas
    33 Genomics in Leukemias
    34 Lung Cancer
    35 Genomics in the Diagnosis and Management of Breast Cancer
    36 Colorectal Cancer
    37 Prostate Cancer
    38 Genomic Assessment of Ovarian Cancer
    39 Genomic Evaluation of Pancreatic Neoplasms
    40 Genomic Evaluation of Head and Neck Cancer
    41 Genomic Medicine, Evaluation of Brain Tumors and Gliomas
    42 Diagnostic - Therapeutic Combinations in the Targeted Therapies for Treatment of Cancer

     Section 6 - Clinical (Inflammatory Disease)
    43 Genomics in the Evaluation and Management of Rheumatoid Arthritis
    44 "Omics" in the Genomic Evaluation of Multiple Sclerosis
    45 Genomic Assessment of Inflammatory Bowel Disease
    46 Asthma Genomics
    47 Genomic Aspects in the Evaluation and Management of Chronic Obstructive Pulmonary Disease
    48 Genetics and Genomics of Interstitial Lung Disease
    49 Peptic Ulcer Disease

     Section 7 – Clinical (Metabolic Disease)
    50 Genomics in Pathogenesis of Cirrhosis
    51 Genomic Medicine and Obesity
    52 Diabetes

     Section 8 – Clinical (Neurological Disease)
    53 Genetics and Genomics of Dementia
    54 Genetics and Genomics of Parkinson’s Disease
    55 Genomic Considerations in Opthamology
    56 Genomics in the Diagnosis and Management of Depression

     Section 9 – Clinical (Infectious Disease)
    57 "Genomic Approaches to
    the Host Response to Pathogens"
    58 Host Genomics and Bacterial Infections
    60 Diagnosis, Genomics, and the Management of Hepatitis

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