Essentials of Biopharmaceutics and Pharmacokinetics book cover

Essentials of Biopharmaceutics and Pharmacokinetics

Essentials of Biopharmaceutics and Pharmacokinetics

Kar’s Essentials of Biopharmaceutics and Pharmacokinetics deals with how a drug exerts its action in the human body through the fundamentals of absorption, distribution, metabolism and excretion. The book adopts a growth-oriented format and design that is developed systematically and methodically.

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Published: September 2010

Imprint: Elsevier

ISBN: 978-81-312-3262-0

Contents

  • CONTENTS

     

    Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean? 1

    Chapter 1 Introduction to Biopharmaceutics and Pharmacokinetics 3

    1. Introduction 3

    2. Historical Perspective of Biopharmaceutics 3

    3. Extravascular Administration of a Drug 6

    4. Scope of Biopharmaceutics 7

    5. Variants in Biopharmaceutics 7

    6. Pharmacokinetics 8

    7. Clinical Pharmacokinetics 10

    8. Pharmacodynamics 12

    9. Toxicokinetics and Clinical Toxicology 13

    10. Bioavailability 13

    11. Bioequivalence 17

    Section 2 Biopharmaceutics 23

    Chapter 2 Biopharmaceutics 25

    1. Introduction 25

    2. Biopharmaceutics Classifi cation System (BCS) 29

    3. In Vitro-In Vivo Correlation (IVIVC): An Introspection 30

    4. Passage of Drugs across Biological Barrier 33

    5. Factors Infl uencing Drug Absorption 43

    6. Mechanisms of Drug Absorption 58

    7. Drug Absorption vs. Bioavailability 72

     

    Section 3 Pharmacokinetics 121

    Chapter 3 Pharmacokinetics 123

    1. Introduction 123

    2. Clinical Signifi cance of Plasma Protein Drug Concentration

    Measurement 124

    3. Pharmacokinetic Models 133

    4. Pharmacokinetics of Drug Absorption 154

    5. Volume of Distribution and Distribution Coeffi cient 170

    6. Organ-Specifi c Clearance 173

    7. Non-Linear Pharmacokinetics 195

    8. Pharmacokinetic Profi les of Some Specifi c Examples

    from Various Classes of Drugs 206

    Section 4 Clinical Pharmacokinetics 215

    Chapter 4 Clinical Pharmacokinetics 217

    1. Introduction 217

    2. Dosage Regimens: Design, Modalities and Implementation 221

    3. Single Dose Bioequivalence Study: Design and Relevant Statistics 248

    4. Pharmacokinetic Drug Interaction: Signifi cance in Combination Therapy 275

     

    Section 5 Bioavailability and Bioequivalence 283

    Chapter 5 Bioavailability and Bioequivalence 285

    1. Introduction 285

    2. Bioavailability 291

    3. Bioequivalence 327

    4. Bioanalytical Method Development and Validation for Bioavailability and Bioequivalence Studies 336

    Index 347

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