Escherichia coli book cover

Escherichia coli

Pathotypes and Principles of Pathogenesis

The 2e of Escherichia coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. This work concludes with a presentation of virulence factors common to two or more pathotypes. The book is a great resource for references and up-to-date knowledge for anyone who studies E. coli pathogenesis, either as established investigators or investigators new to the field. It is also an excellent text for those who teach mechanisms of pathogenesis to graduate students and medical students and wish to have a source of knowledge from which to develop lectures.

Microbiologists, cell biologists, infectious disease clinicians, food safety experts, veterinarians, and advanced students.

Hardbound, 612 Pages

Published: August 2013

Imprint: Academic Press

ISBN: 978-0-12-397048-0


  • "The Escherichia coli (E. coli) bacteria is the most common facultative anaerobe in the human intestinal tract, and most strains are non-pathogenic and even symbiotic. It is the pathogenic strains that scientists from around the world consider here, looking at the organism itself, pathotypes, and virulence factors."--Reference & Research Book News, October 2013


  • Section I: Escherichia coli, the Organism
    The Biology and Ecology of Pathogenic E. coli
    Comparative Genomics of Pathogenic E. coli
    Evolution of Pathogenic E. coli
    Section II: Escherichai coli Pathotypes
    Enteropathogenic E. coli
    Enterohemorrhagic and other Shiga-toxin Producing E. coli
    Enterotoxigenic E. coli
    Shigella and Enteroinvasive E. coli
    Enteroaggregative E. coli
    Uropathogenic E. coli
    Meningitis-Associated E. coli
    Hybrid and Potentially Pathogenic E. coli strains
    Section III: Escherichia coli Virulence Factors
    Adhesive Pili of the Chaperone-Usher Family
    Type IV Pili and Type 2 Secretion Systems
    Type 3 Secretion Systems
    Type 3 Secretion Effectors
    Types 1 and 5 Secretion Systems and Toxins
    Capsule and Lipopolysaccharide


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