Epigenetics in Human Disease

Edited by

Trygve Tollefsbol, Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol's research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women's Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biot

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike.

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Hardbound, 592 Pages

Published: July 2012

Imprint: Academic Press

ISBN: 978-0-12-388415-2

Reviews

"This book covers a huge range of topics, from early life effects on adult disease to epigenetic changes occurring with aging and senescence. Especially pertinent are the several chapters on epigenetic treatments for disease including drugs, miRNA/siRNA, natural substances and foods. With up to date coverage of an ever expanding field, Epigenetics in Human Disease will be a great resource for clinicians, researchers and students."
Craig Cooney, Investigator, Research Service, Veteran's Affairs Medical Center, Little Rock, AR & Affiliate Scientist, Nanotechnology Center, University of Arkansas, Little Rock, AR

1. Epigenetics of Human Disease
  Methods and Strategies to Determine Epigenetic Variation in Human Disease
  DNA Methylation Alterations in Human Cancers
  Alterations of Histone Modifications in Cancer
  MicroRNA in Oncogenesis
  Epigenetic Approaches to Cancer Therapy
  Epigenomics in Neurobehavioral Diseases
  Emerging Role of Epigenetics in Human Neurodevelopmental Disorders
  The Epigenetics of Alzheimers Disease
  Epigenetic Modulation of Human Neurobiological Disorders
  Epigenetic Basis of Autoimmune Disorders in Humans
  Approaches to Autoimmune Diseases Using Epigenetic Therapy
  Epigenetic Mechanisms of Human Imprinting Disorders
  Epigenomic Factors in Human Obesity
  Epigenetic Approaches to Control Obesity
  Epigenetics of Diabetes in Humans
  The Potential of Epigenetic Compounds in Treating Diabetes
  Epigenetic Aberrations in Human Allergic Diseases,
  Therapy of Airway Disease: Epigenetic Potential
  The Role of Epigenetics in Cardiovascular Disease
  Epigenetics and Human Infectious Diseases
  The Epigenetics of Endometriosis
  Aberrant DNA Methylation in Endometrial Cancer
  Stem Cell Epigenetics and Human Disease
  Non-Coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy
  Aging and Disease: The Epigenetic Bridge
  Early-Life Epigenetic Programming of Human Disease and Aging

Epigenetics in Human Disease

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