Epigenetics in Human Disease

Edited by

  • Trygve Tollefsbol, Professor of Biology, University of Alabama at Birmingham, AL, USA

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike.
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Researchers working in basic molecular biology, genetics, and clinical therapy who are interested in either the underlying basis of human diseases or novel means to treat human diseases; advanced undergraduate students, graduate students, university researchers, pharmaceutical company and biotechnology researchers interested in drug development and therapies.


Book information

  • Published: July 2012
  • ISBN: 978-0-12-388415-2


"This volume constitutes a comprehensive survey of the emerging field of epigenetics in the etiology, progression, diagnosis, prognosis and treatment of human diseasesā€¦ With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike."--Anticancer Research, Volume 33, Issue no. 5, May 2013
"This book covers a huge range of topics, from early life effects on adult disease to epigenetic changes occurring with aging and senescence. Especially pertinent are the several chapters on epigenetic treatments for disease including drugs, miRNA/siRNA, natural substances and foods. With up to date coverage of an ever expanding field, Epigenetics in Human Disease will be a great resource for clinicians, researchers and students."--Craig Cooney, Investigator, Research Service, Veteran's Affairs Medical Center, Little Rock, AR & Affiliate Scientist, Nanotechnology Center, University of Arkansas, Little Rock, AR

Table of Contents

  1. Epigenetics of Human Disease

    Methods and Strategies to Determine Epigenetic Variation in Human Disease

    DNA Methylation Alterations in Human Cancers

    Alterations of Histone Modifications in Cancer

    MicroRNA in Oncogenesis

    Epigenetic Approaches to Cancer Therapy

    Epigenomics in Neurobehavioral Diseases

    Emerging Role of Epigenetics in Human Neurodevelopmental Disorders

    The Epigenetics of Alzheimerā€™s Disease

    Epigenetic Modulation of Human Neurobiological Disorders

    Epigenetic Basis of Autoimmune Disorders in Humans

    Approaches to Autoimmune Diseases Using Epigenetic Therapy

    Epigenetic Mechanisms of Human Imprinting Disorders

    Epigenomic Factors in Human Obesity

    Epigenetic Approaches to Control Obesity

    Epigenetics of Diabetes in Humans

    The Potential of Epigenetic Compounds in Treating Diabetes

    Epigenetic Aberrations in Human Allergic Diseases,

    Therapy of Airway Disease: Epigenetic Potential

    The Role of Epigenetics in Cardiovascular Disease

    Epigenetics and Human Infectious Diseases

    The Epigenetics of Endometriosis

    Aberrant DNA Methylation in Endometrial Cancer

    Stem Cell Epigenetics and Human Disease

    Non-Coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy

    Aging and Disease: The Epigenetic Bridge

    Early-Life Epigenetic Programming of Human Disease and Aging