Epigenetic Regulation in the Nervous System

Basic Mechanisms and Clinical Impact

Edited by

  • J. David Sweatt, University of Alabama, Birmingham, AL, USA
  • Michael J. Meaney, Douglas Institute, McGill University, Montreal, Canada
  • Eric Nestler, Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
  • Schahram Akbarian, Department of Psychiatry, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.

Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.

Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.

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Researchers and advanced students in molecular/cellular, developmental and behavioral neuroscience; clinical neuroscientists; research psychiatrists and psychologists


Book information

  • Published: February 2013
  • ISBN: 978-0-12-391494-1


"Sweatt, Meaney, Nestler, and Akbarian present the first foundational work to address molecular, cellular, behavioral, and clinical roles for epigenetic mechanisms in the nervous system…This unique book is targeted for physicians and scientists, as well as researchers and students."--Reference & Research Book News, October 2013

Table of Contents

1. An Overview of the Molecular Basis of Epigenetics
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian

2. Histone modifications in the nervous system and neuropsychiatric disorders
Morgan Bridi and Edwin "Ted" Abel

3. Active DNA Demethylation and 5-Hydroxymethylcytosine
Junjie U. Guo, Guo-li Ming and Hongjun Song

4. Maternal Behavior
Tie Yuan Zhang, Christian Caldji, Josie C. Diorio, Sabine Dhir, Gustavo Turecki, and Michael J. Meaney

5. Epigenetic Mechanisms in Learning and Memory
Jeremy J. Day and J. David Sweatt

6. Drug Addiction and Reward
Alfred J. Robison, Jian Feng, and Eric J. Nestler

7. The Mind and its Nucleosomes - Chromatin (dys)regulation in Major Psychiatric Disease
Rahul Bharadwaj,  Cyril J. Peter, and Schahram Akbarian

8. HDAC inhibitors as novel therapeutics in Aging, and Alzheimer's disease
Alexi Nott, Daniel M. Fass, Stephen J. Haggarty, and Li-Huei Tsai

9. Cell Differentiation in the CNS, Neuronal Fate Determination, and Development
Yi Eve Sun

10. Imprinting in the CNS and Neurodevelopmental Disorders
Weston T. Powell and Janine LaSalle

11. Neuronal Genomic and Epigenetic Diversity
Michael J. McConnell and Fred H. Gage

12. Adult Neurogenesis
Jenny Hsieh, Hongjun Song

13. Transgenerational Inheritance in Mammals
Isabelle M. Mansuy, Rahia Mashoodh and Francis A. Champagne

14. Open Questions and Future Approaches in Neuroepigenetics
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian