Epigenetic Regulation in the Nervous System
Basic Mechanisms and Clinical Impact
Edited by- J. David Sweatt, University of Alabama, Birmingham, AL, USA
- Michael J. Meaney, Douglas Institute, McGill University, Montreal, Canada
- Eric Nestler, Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
- Schahram Akbarian, Department of Psychiatry, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
Behavioral Epigenetics is the study of how environmental factors affect alterations in behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcome. With an understanding of the molecular mechanisms involved in epigenetic modulation, researchers believe it will be possible to develop targeted therapies for those individuals in whom it malfunctions.
This volume will address current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. It will span molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and will be unique in its incorporation of epigenetically based disorders of the CNS.
Edited by the most highly regarded leaders in the field, the volume will offer a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material and specific topics of emerging excitement, it will serve as both a cutting edge resource and a foundational reference. Neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior will benefit, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.
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Published: December 2012
Imprint: Academic Press
ISBN: 978-0-12-391494-1
Contents
1. An Overview of the Molecular Basis of Epigenetics
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian2. Histone modifications in the nervous system and neuropsychiatric disorders
Morgan Bridi and Edwin "Ted" Abel3. Active DNA Demethylation and 5-Hydroxymethylcytosine
4. Maternal Behavior
Junjie U. Guo, Guo-li Ming and Hongjun Song
Tie Yuan Zhang, Christian Caldji, Josie C. Diorio, Sabine Dhir, Gustavo Turecki, and Michael J. Meaney5. Epigenetic Mechanisms in Learning and Memory
6. Drug Addiction and Reward
Jeremy J. Day and J. David Sweatt
Alfred J. Robison, Jian Feng, and Eric J. Nestler7. The Mind and its Nucleosomes - Chromatin (dys)regulation in Major Psychiatric Disease
8. HDAC inhibitors as novel therapeutics in Aging, and Alzheimer's disease
Rahul Bharadwaj, Cyril J. Peter, and Schahram Akbarian
Alexi Nott, Daniel M. Fass, Stephen J. Haggarty, and Li-Huei Tsai9. Cell Differentiation in the CNS, Neuronal Fate Determination, and Development
10. Imprinting in the CNS and Neurodevelopmental Disorders
Yi Eve Sun
Weston T. Powell and Janine LaSalle11. Neuronal Genomic and Epigenetic Diversity
12. Adult Neurogenesis
Michael J. McConnell and Fred H. Gage
Jenny Hsieh, Hongjun Song13. Transgenerational Inheritance in Mammals
14. Open Questions and Future Approaches in Neuroepigenetics
Isabelle M. Mansuy, Rahia Mashoodh and Francis A. Champagne
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian

