Chapter One: The Endocannabinoid Signaling System in the CNS: A Primer
- Abstract
- 1 Introduction
- 2 The Endocannabinoids
- 3 Endocannabinoid Receptors
- 4 CB1R and Retrograde Regulation of Synaptic Activity
- 5 Summary
- Acknowledgments
Chapter Two: Evidence for a Role of Adolescent Endocannabinoid Signaling in Regulating HPA Axis Stress Responsivity and Emotional Behavior Development
- Abstract
- 1 Adolescence and Pubertal Maturation
- 2 The Neurobiology of Stress
- 3 Adolescent HPA Axis Development
- 4 The Developmental Influence of Gonadal Hormones on the HPA Axis
- 5 The Endocannabinoid System
- 6 Endocannabinoid System Regulation of the HPA Axis in Adulthood
- 7 Ontogeny of the Endocannabinoid System
- 8 Adolescent HPA Axis Function: A Regulatory Role for the Endocannabinoid System?
- 9 Concluding Remarks
- Acknowledgments
Chapter Three: The Endocannabinoid System and Its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestinal Tract
- Abstract
- 1 Introduction
- 2 The Enteric Nervous System and the Brain–Gut Axis
- 3 The Endocannabinoid System
- 4 Endocannabinoid Signaling Mechanisms
- 5 Other Receptors, Agonists, and Antagonists
- 6 Endocannabinoid Tone
- 7 Cannabinoid Receptor Metaplasticity in the ENS
- 8 Cannabinoid Receptor Properties
- 9 Enteric Glia
- 10 Neurotransmission in the ENS and GI Tract
- 11 Brain–Gut Axis
- 12 The Endocannabinoid System of the ENS in GI Inflammation
- 13 Summary and Future Directions
- Disclosures
Chapter Four: Endocannabinoid Mechanisms Influencing Nausea
- Abstract
- 1 Endocannabinoids in Acute Nausea
- 2 Endocannabinoids in Anticipatory Nausea
- 3 Conclusions
Chapter Five: Endocannabinoid Regulation of Neuroendocrine Systems
- Abstract
- 1 The Endocannabinoids and Their Receptors
- 2 Cannabinoid Regulation of the Neuroendocrine Stress Response
- 3 Endocannabinoid Regulation of Energy Homeostasis
- 4 Endocannabinoids and Fluid Homeostasis
- 5 Endocannabinoid Regulation of Reproduction
Chapter Six: The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress
- Abstract
- 1 Introduction
- 2 The Endocannabinoid System
- 3 The Endocannabinoid System in the Brain Regulates Pain
- 4 The Modulation of Pain by Stress: Role for the Brain's Endocannabinoid System
- 5 The Role of the Endocannabinoid System in the Rostral Ventromedial Medulla in Pain, Stress-Induced Analgesia, and Stress-Induced Hyperalgesia
- 6 The Role of the Endocannabinoid System in the Periaquaductal Gray in Pain, Stress-Induced Analgesia, and Stress-Induced Hyperalgesia
- 7 The Role of the Endocannabinoid System in the Amygdala in Pain, Stress-Induced Analgesia, and Stress-Induced Hyperalgesia
- 8 The Role of the Endocannabinoid System in the Prefrontal Cortex in Pain, Stress-Induced Analgesia, and Stress-Induced Hyperalgesia
- 9 Less Characterized Supraspinal Endocannabinoid Mechanisms in Pain Modulation
- 10 Concluding Remarks
- Acknowledgments
Chapter Seven: Endocannabinoid Signaling in Motivation, Reward, and Addiction: Influences on Mesocorticolimbic Dopamine Function
- Abstract
- 1 Introduction
- 2 The Neurobiology of Reward
- 3 The Influence of Endocannabinoid Signaling on Reward
- 4 The Role of the Endocannabinoid System in Motivation
- 5 Drug Addiction and the Endocannabinoid System: A Reciprocal Modulation of Synaptic Plasticity
- 6 Concluding Remarks
- Acknowledgments