Electroporation-Based Therapies for Cancer

From Basics to Clinical Applications

Edited by

  • R. Sundararajan, Purdue University, USA

Electroporation-Based Therapies for Cancer reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals.

Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and chemo-resistant cancers, that do not respond well to current treatment regimen. An electrical-pulse-mediated, enhanced drug delivery technique known as electroporation is one way to effectively treat these patients.

This technique is especially suitable for low- and middle-income countries, where lack of infrastructure and resources leads to cancer diagnoses at late stages. This quick, safe, effective, economical, out-patient-based technique is a boon to these patients for palliative and other care with enhanced quality of life. This book features discussions by interdisciplinary authors-including practicing oncological surgeons, medical professionals, and academic and other researchers-of the basics and clinical medical applications of electroporation.

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Audience

Oncological surgeons, medical professionals, academic and other researchers.

 

Book information

  • Published: July 2014
  • Imprint: Woodhead Publishing
  • ISBN: 978-1-907568-15-2


Table of Contents

Clinical electro-chemo-therapy for advanced superficial melanoma; Effective electro-chemo-therapy for chest wall recurrence of breast carcinoma; Electrochemotherapy - Aspects of clinical experience; Low and high voltage electro-chemo-therapy for breast cancer: An in vitro model study; Electrically-enhanced proliferation control of cancer-stem-cell-like adult human mesenchymal stem cells a novel modality of treatment; Why electroporation is a useful technique for cancer treatments; Electro-endocrine therapy for breast cancer; Electroporation of cervical and leukemia cancer cells; Targeted delivery of siRNA and other difficult to transfect molecules using electroporation; Nanosecond, low voltage pulses for electro-endocrine therapy; Low and high voltage electroporation of ovarian cancer cells; Irreversible electroporation; Electric field distribution study of malignant tumors.