Electroporation-Based Therapies for Cancer book cover

Electroporation-Based Therapies for Cancer

From Basics to Clinical Applications

Electroporation-based therapies for cancer looks at electroporation-based therapies for cancer. Cancer kills about one American per minute, amounting to over 500,000 deaths in the US and millions, worldwide, each year.

There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring and chemo-resistant cancers, that do not respond well to current treatment regimen. Electrical-pulse-mediated, enhanced drug delivery technique, known as electroporation is one of the ways to effectively treat these patients. Towards this end, this book provides a comprehensive overview of electroporation-based clinical studies in the hospitals for various cancer treatments including melanomas, head and neck cancers, chest wall breast carcinomas and colorectal cancers and research studies in the lab using cell lines, primary cells, and animals. This technique is especially suitable for low and middle-income countries, where due to lack of infrastructure and resources, many cancers are diagnosed at late stages and this safe, effective, economical, out-patient-based and quick (it only takes a few minutes to treat a tumor) technique is a boon to these patients for palliative and other care with enhanced quality of life. From basics to clinical medical applications of electroporation are discussed by interdisciplinary authors including practicing oncological surgeons, medical professional, and academic and other researchers.

Audience

Oncological surgeons, medical professionals, academic and other researchers.

Hardbound, 250 Pages

Published: July 2014

Imprint: Woodhead Publishing

ISBN: 978-1-907568-15-2

Contents

  • Clinical electro-chemo-therapy for advanced superficial melanoma; Effective electro-chemo-therapy for chest wall recurrence of breast carcinoma; Electrochemotherapy - aspects of clinical experience; Low and high voltage electro-chemo-therapy for breast cancer: An in vitro model study; Electrically-enhanced proliferation control of cancer-stem-cell-like adult human mesenchymal stem cells a novel modality of treatment; Why electroporation is a useful technique for cancer treatments; Electro-endocrine therapy for breast cancer; Electroporation of cervical and leukemia cancer cells; Targeted delivery of siRNA and other difficult to transfect molecules using electroporation; Nanosecond, low voltage pulses for electro-endocrine therapy; Low and high voltage electroporation of ovarian cancer cells; Irreversible electroporation; Electric field distribution study of malignant tumors.

Advertisement

advert image