E. coli

Genomics, Evolution and Pathogenesis

Edited by

  • Michael Donnenberg, University of Maryland School of Medicine, Baltimore, U.S.A.
  • Michael Donnenberg, University of Maryland School of Medicine, Baltimore, U.S.A.

DescriptionAlthough most strains of E. coli bacteria are harmless and live in the intestines of healthy humans and animals, several strains can produce powerful toxins and cause severe illness in humans. This versatile pathogen is best known for being transmitted to humans through contaminated foods - such as undercooked meat and unpasteurized fruit juice - and has attracts much attention when serious outbreaks occur.Importance of TopicE. coli is capable of causing a wide variety of diseases - from urinary tract infections to meningitis. A considerable amount of media coverage has recently been devoted to one particular strain of E. coli, responsible for an estimated 73,000 cases of infection and 61 deaths in the United States each year. Knowing more about the biology, the evolution, and the genetic basis of this pathogen is crucial to future prevention of infection and illness.Why This TitlePathogenic E. coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. Pathogenic E. coli concludes with a presentation of virulance factors, common to two or more pathotypes. This unique collection presents timely and vital information on understanding the inner workings of E. coli, which will lend key insights into disease prevention research.
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Microbiologists, cell biologists, infectious disease clinicians, food safety experts, veterinarians, and advanced students.


Book information

  • Published: September 2002
  • ISBN: 978-0-12-220751-8


"...a thorough, timely treatise on the current state of the field for researchers and advanced graduate students in bacterial pathogenesis. It is also an excellent and valuable reference work of general interest to microbiologists, infectious disease specialists, and food safety experts, and should be included in microbiology and medical reference libraries."-ASM NEWS (June 2003) "...a very informative book which is well presented and would be excellent value for money for scientists generally interested in the basis of microbial pathogenesis, as well as E. coli specifically."-MICROBIOLOGY TODAY (August 2003)

Table of Contents

Introduction. SECTION ONE: E. coli THE ORGANISMThe genomes of E. coli K-12 and pathogenic E. coli. The evolution of pathogenic E. coli. SECTION TWO: E. coli PATHOTYPESEnteropathogenic E. coli.Enterotoxigenic E. coli.Enteroaggregative and Diffuse-Adhering E. coli.Shigella and Enteroinvasive E. coli.Uropathogenic E. coli.Meningitis-associated E. coli.SECTION THREE: E. coli VIRULENCE FACTORS Adhesive Pili of the Chaperone-Usher Family.Type IV Pili.Type III Secretion.Hemolysin.Capsule and Lipopolysaccharide.