Dyneins book cover


Structure, Biology and Disease

Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.


Laboratory and clinical researchers across cell biology, developmental biology, genetics, protein chemistry, neurobiology, biophysics, biomedicine and medicine.

Hardbound, 656 Pages

Published: August 2011

Imprint: Academic Press

ISBN: 978-0-12-382004-4


  • I History and Evolution

    Chapter 1 Discovery of Dynein and its Properties : A Personal Account

    Chapter 2 Evolutionary Biology of Dyneins

    II Structure and Mechanics of Dynein Motors

    Chapter 3 The AAA+ Powerhouse-Trying to Understand How it Works

    Chapter 4 Dynein Motor Mechanisms

    Chapter 5 Structural Analysis of Dynein Intermediate and Light Chains

    Chapter 6 Biophysics of Dynein In Vivo

    III Dyneins in Ciliary Biology

    Chapter 7 Composition and Assembly of Axonemal Dyneins

    Chapter 8 Organization of Dyneins in the Axoneme

    Chapter 9 Genetic Approaches to Axonemal Dynein Function in Chlamydomonas and Other Organisms

    Chapter 10 Regulation of Axonemal Outer-Arm Dyneins in Cilia

    Chapter 11 Control of Axonemal Inner Dynein Arms

    Chapter 12 Flagellar Motility and the Dynein Regulatory Complex

    Chapter 13 Regulation of Dynein in Ciliary and Flagellar Movement

    Chapter 14 Dynein and Intraflagella Transport

    IV Cytoplasmic Dynein Biology

    Chapter 15 Cytoplasmic Dynein Function Define by Subunit Composition

    Chapter 16 Studies of Lissencephaly and Neurodegenerative Disease Reveal Novel Aspects of

    Chapter 17 Insights into Cytoplasmic Dynein Function and Regulation from Fungal Genetics

    Chapter 18 Genetic Insights in to Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in Mouse

    Chapter 19 Role of Dynactin in Dynein-mediated Motility

    Chapter 20 Roles of Cytoplasmic Dynein during Mitosis

    V Dynein Dysfunction and Disease

    Chapter 21 Does Dynein Influence the Non -Mendelian Inheritance of Chromosome 17 Homologs in Male Mice?

    Chapter 22 Role of Dynein in Viral Pathogenesis

    Chapter 23 Cytoplasmic Dynein Dysfunction and Neurodegenerative Disease

    Chapter 24 Dynein Dysfunction as a Cause of Primary Ciliary Dyskinesia and Other Ciliopathies


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