Structure, Biology and DiseaseEdited by
- Stephen King, University of Texas, MD Anderson Cancer Center,Michale E. Keeling Center for Comparative Medicine and Research, Bastrop, Texas, U.S.A.
Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.
Laboratory and clinical researchers across cell biology, developmental biology, genetics, protein chemistry, neurobiology, biophysics, biomedicine and medicine.
Hardbound, 656 Pages
Published: August 2011
Imprint: Academic Press
I History and Evolution
Chapter 1 Discovery of Dynein and its Properties : A Personal Account
Chapter 2 Evolutionary Biology of DyneinsII Structure and Mechanics of Dynein Motors
Chapter 3 The AAA+ Powerhouse-Trying to Understand How it WorksChapter 4 Dynein Motor Mechanisms
Chapter 5 Structural Analysis of Dynein Intermediate and Light ChainsChapter 6 Biophysics of Dynein In Vivo
III Dyneins in Ciliary BiologyChapter 7 Composition and Assembly of Axonemal Dyneins
Chapter 8 Organization of Dyneins in the AxonemeChapter 9 Genetic Approaches to Axonemal Dynein Function in Chlamydomonas and Other Organisms
Chapter 10 Regulation of Axonemal Outer-Arm Dyneins in CiliaChapter 11 Control of Axonemal Inner Dynein Arms
Chapter 12 Flagellar Motility and the Dynein Regulatory ComplexChapter 13 Regulation of Dynein in Ciliary and Flagellar Movement
Chapter 14 Dynein and Intraflagella TransportIV Cytoplasmic Dynein Biology
Chapter 15 Cytoplasmic Dynein Function Define by Subunit CompositionChapter 16 Studies of Lissencephaly and Neurodegenerative Disease Reveal Novel Aspects of
Chapter 17 Insights into Cytoplasmic Dynein Function and Regulation from Fungal GeneticsChapter 18 Genetic Insights in to Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in Mouse
Chapter 19 Role of Dynactin in Dynein-mediated MotilityChapter 20 Roles of Cytoplasmic Dynein during Mitosis
V Dynein Dysfunction and DiseaseChapter 21 Does Dynein Influence the Non -Mendelian Inheritance of Chromosome 17 Homologs in Male Mice?
Chapter 22 Role of Dynein in Viral PathogenesisChapter 23 Cytoplasmic Dynein Dysfunction and Neurodegenerative Disease
Chapter 24 Dynein Dysfunction as a Cause of Primary Ciliary Dyskinesia and Other Ciliopathies