Dubois' Lupus Erythematosus and Related Syndromes

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Recognized for more than 45 years as the definitive text in the field, Dubois’ Lupus Erythematosus and Related Syndromes strikes the perfect balance between basic science and clinical expertise, providing the evidence-based findings, treatment consensuses, and practical clinical information you need to confidently diagnose and manage SLE.

Hardbound, 712 Pages

Published: October 2012

Imprint: Saunders

ISBN: 978-1-4377-1893-5


  • "This is a comprehensive and extensive review of the definition, pathogenesis, serological/clinical manifestations, and current management guidelines of these syndromes. Chapters are organized well, for example, the clinical manifestations section is divided by organ system. Also helpful is the separate chapter on pregnancy in women with SLE, an issue I deal with on a regular basis.  This is a thorough reference on lupus erythematosus, covering every aspect of this heterogeneous systemic autoimmune disease. "

    - Maria Gonzalez-Mayda, M.D,Washington University Medical Center

    4 Star - Doody's Rating, March 2013


  • Section I: What is Lupus?

    1. Definition and classification of Lupus and Lupus-Related Disorders

    2. The Epidemiology of Lupus

    Section II: The Pathogenesis of Lupus

    3. The Pathogenesis of SLE

    4. Genetics of Human SLE

    5. Epigenetics of Lupus

    6. The Innate Immune System in SLE

    7. Cytokines and Interferons in Lupus

    8. The Structure and Derivation of Antibodies and Autoantibodies

    9. T Cells

    10. Regulatory Cells in SLE

    11. Apoptosis, Necrosis, and Autophagy

    12. Abnormalities in Immune Complex Clearance and Fcy Receptor Function

    13. Neural-Immune Interactions: Principles and Relevance to SLE

    14. Complement and SLE

    15. Mechanisms of Acute Inflammation and Vascular Injury in SLE

    16. Mechanisms of Tissue Damage - Free Radicals and Fibrosis

    17. Animal Models of SLE

    18. Pathogenic Mechanisms in Lupus Nephritis

    Section III: Autoantibodies

    19. Immune Tolerance Defects in Lupus

    20. Autoantibodies

    21. Autoantigenesis and Entigen-Based Therapy and Vaccination in SLE

    Section IV: Clinical Aspects of SLE

    22. Overview and Clinical Presentation

    23. Pathomechanisms of Cutaneous Lupus Erythematosus

    24. Skin Disease in Cutaneous Lupus Erythematosus

    25. The Musculoskeletal System and Bone Metabolism

    26. Pathogenesis and Treatment of Atherosclerosis in Lupus

    27. Cardiopulmonary Disease in SLE

    28. Pathogenesis of the Nervous System

    29. Clinical Aspects of the Nervous System

    30. Psychopathology, Neurodiagnostic Testing, and Imaging

    31. Ocular, Aural, and Oral Manifestations

    32. Management of Sjögren Syndrome in Patients with SLE

    33. Gastrointestinal and Hepatic Manifestations

    34. Hematologic and Lymphoid Abnormalities in SLE

    35. Clinical and Epidemiologic Features of Lupus Nephritis

    Section V: The Reproductive System & Hormones

    36. Pregnancy in Women with SLE

    37. Neonatal Lupus Erythematosus

    38. Reproductive and Hormonal Issues in Women with Autoimmune Diseases

    Section VI: Special Considerations, Subsets of SLE and Lupus-Related Syndromes

    39. Drug-Induced Lupus: Etiology, Pathogenesis, and Clinical Aspects

    40. SLE in Childhood and Adolescence

    41. Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease

    42. Clinical Aspects of the Antiphospholipid Syndrome

    Section VII: Assessment of Lupus

    43. Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Clinical Laboratory Tests in SLE

    44. Differential Diagnosis and Disease Associations

    45. SLE and Infections

    46. Clinical Measures, Metrics and Indices

    Section VIII: Management of SLE

    47. Principles of Therapy, Local Measures, Nonsteroidal Medications

    48. Systemic Glucocorticoid Therapy in SLE

    49. Antimalarial Medications

    50. Immunosuppressive Drug Therapy

    51. Specialized Treatment Approaches and Niche Therapies for Lupus Subsets

    52. Adjunctive and Preventive Measures

    53. Novel Therapies for SLE: Biological Agents Available in Practice Today

    54. Critical Issues in Drug Development for SLE

    55. Socioeconomic and Disability Aspects

    Section IX: Outcomes and Future Considerations

    56. Investigational Agents and Future Therapy for SLE

    57. Mortality in SLE

    Appendix: Lupus Resource Materials



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