Drug-Drug Interactions: Scientific and Regulatory Perspectives book cover

Drug-Drug Interactions: Scientific and Regulatory Perspectives

Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

Audience
Professionals in the pharmaceutical industry, health care industry, and governmental regulatory agencies. Students and researchers in the areas of pharmacology, toxicology, pharmacokinetics, and medicine.

Included in series
Advances in Pharmacology

Hardbound, 304 Pages

Published: October 1997

Imprint: Academic Press

ISBN: 978-0-12-032944-1

Reviews

  • "Recommended not only to pharmacologists but also to all those in related disciplines."
    Praise for the Series, --NATURE


    "The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated."
    --H.E. Kaufmann in CHEMOTHERAPY
    "Superb reading material."
    --JOURNAL OF PHARMACEUTICAL SCIENCES
    "This book represents a comprehensive review of drug-drug interaction and is unique since the contributors are from all facets of the workplace, including academic institutes, government, and industry... The most attractive feature of the book is its well-focused subject area with the emphasis on the importance of P-450 enzymes in drug interactions and how government regulatory agencies evaluate them... It is unique since it presents the regulatory aspects of drug evaluations as an integral part of the science of drug-drug interactions."
    --Rajendar Mehta, PhD, University of Illinois at Chicago College of Medicine for DOODY'S PUBLISHING

Contents

  • J. Collins, Foreword.A.P. Li, Preface.A.P. Li, Overview: Scientific Basis of Pharmacokinetic Drug-Drug Interactions.F.P. Guengerich, Role of Cytochrome P450 Enzymes in Drug-Drug Interactions.J.M. Sauer, E.R. Stine, L. Gunawardhana, D.A. Hill, and I.G. Sipes, The Liver as a Target for Chemical-Chemical Interactions.A.D. Rodrigues and S.L. Wong, Applications of Human Liver Microsomes in Metabolism-Based Drug-Drug Interactions.A.P. Li, Applications of Human Hepatocytes as an Experimental System for the Evaluation of Pharmacokinetic Drug-Drug Interactions.J.L. Ferrero and K. Brendal, Liver Slices as a Model in Drug Metabolism and Drug-Drug Interactions.C.L. Crespi and B.W. Penman, The Use of cDNA Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions.G.L. Kedderis, Pharmacokinetics of Drug Interactions.T.N. Thompson, Experimental Models for Evaluating Enzyme Induction Potential of New Drug Candidates in Animals and Man and a Strategy for Their Use.J.D. Balian, Metabolic Drug-Drug Interactions: Perspective from U.S. FDA Medical and Clinical Pharmacology Reviewers.M. Jurima-Romet, Drug Interactions: Perspectives of the Canadian Directorate.

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