Drug-Biomembrane Interaction Studies
The Application of Calorimetric Techniques
- Rosario Pignatello, University of Catania, Italy
The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material.View full description
Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions.
Scientists and researchers within academia, pharmaceutical industries and nanotechnology industries in the fields of drug discovery, drug development and drug delivery; Undergraduate and graduate students in the fields of chemistry, pharmaceutical chemistry, pharmaceutics, pharmaceutical technology and physical chemistry; Physical chemists, biochemists and pharmacologists
- Published: October 2013
- Imprint: Woodhead Publishing
- ISBN: 978-1-907568-05-3
Table of ContentsBiological membranes and their role in physio- pathological conditions; Biomembrane models; Analytical methods for studying drug-biomembrane interactions; Differential scanning calorimetry (DSC): Theoretical fundamentals; DSC: History, instruments and devices; DSC in drug-biomembrane interaction studies; DSC applications: Macromolecules; DSC applications: Nucleic acids and membrane interactions; Non- steroidal anti- infl ammatory drugs; Antimicrobial agents; Drug delivery systems: Drug nanocarriers.