Drug-Biomembrane Interaction Studies book cover

Drug-Biomembrane Interaction Studies

The Application of Calorimetric Techniques

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material.

Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions.

Hardbound, 440 Pages

Published: October 2013

Imprint: Woodhead Publishing

ISBN: 978-1-907568-05-3

Contents

  • Biological membranes and their role in physio- pathological conditions; Biomembrane models; Analytical methods for studying drug-biomembrane interactions; Differential scanning calorimetry (DSC): Theoretical fundamentals; DSC: History, instruments and devices; DSC in drug-biomembrane interaction studies; DSC applications: Macromolecules; DSC applications: Nucleic acids and membrane interactions; Non- steroidal anti- infl ammatory drugs; Antimicrobial agents; Drug delivery systems: Drug nanocarriers.

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