Drug and Enzyme Targeting, Part B, 149

Volume 149: Drug and Enzyme Targeting Part B

  • Ralph Green, The Clevland Clinic Foundation, Ohio, U.S.A.
    • Kenneth Widder, Molecular Biosystems, Inc. and University of California, San Diego, U.S.A.
      • Nathan Colowick, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.
        • Nathan Kaplan


        Biochemists, pharmacologists, toxicologists, analytical chemists, and biomedical researchers.


Book information

  • Published: November 1987
  • ISBN: 978-0-12-182049-7


"The Methods in Enzymology series represents the gold-standard."
Praise for the Series, --NEUROSCIENCE

"Incomparably useful."
Praise for the Series, --ANALYTICAL BIOCHEMISTRY
"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page."
Praise for the Series, --BIO/TECHNOLOGY
"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection."
Praise for the Series, --CHEMISTRY IN INDUSTRY
"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced."
"If we had some way to find the work most often consulted in the laboratory, it could well be Colowick and Kaplan's multi-volume series Methods in Enzymology...a great work."
Praise for the Series, --ENZYMOLOGIA
"A series that has established itself as a definitive reference for biochemists."
Praise for the Series, --JOURNAL OF CHROMATOGRAPHY

Table of Contents

Cell Targeting Techniques:Biochemical Methods for the Study of Receptor-Mediated Endocytosis.High-Efficiency Gene Transfer into Cells.Lectin-Specific Targeting of Lysosomal Enzymes to Reticuloendothelial Cells.Osmotic Lysis of Pinosomes.Liposome Carriers:Multiple Emulsions as Targetable Delivery Systems.High-Pressure Continuous-Flow System for Drug Entrapment in Liposomes.Temperature- and pH-Sensitive Liposomes for Drug Targeting.pH-Sensitive Immunoliposomes.Photolabile Liposomes as Carriers.Covalent Attachment of Proteins to Liposomes.Use of Avidin-Biotin Technology for Liposome Targeting.Complement-Dependent Phagocytosis of Liposomes by Macrophages.Interaction of Liposomes with Cells.Uptake of Liposome-Encapsulated Agents.Liposome-Mediated Macrophage Activities.Liposomes as Carriers for in Vivo Gene Transfer and Expression.Liposome Entrapment for Delivery of Genetic Material to Plant Protoplasts.Liposome-Encapsulated Hemoglobin as an Artificial Oxygen-Carrying System.Use of Liposomes as Agglutination-Enhancement Agents in Diagnostic Tests.Cellular Carriers:Erythrosomes: Erythrocyte Cytoskeletons Coated with Exogenous Phospholipid as an Encapsulating System.Hypotonic Hemolysis Methods for Entrapment of Agents in Resealed Erythrocytes.High-Efficiency Entrapment of Enzymes in Resealed Red Cell Ghosts by Dialysis.Dialysis Method for Entrapment of Proteins into Resealed Red Blood Cells.Large-Scale Entrapment of Drugs into Resealed Red Blood Cells Using a Continuous-Flow Dialysis System.Electric Modification of Membrane Permeability for Drug Loading into Living Cells.Drug-Induced Endocytosis and Entrapment in Red Cells and Ghosts.Preparation of White Resealable Erythrocyte Ghosts.Phospholipid Asymmetry of Loaded Red Cells.Red Cell-Mediated Microinjection.Magnetically Responsive Erythrocyte "Ghosts".Use of Platelets as Drug Carriers for the Treatment of Hematologic Diseases.Author Index.Subject Index.