Disorders of Synaptic Plasticity and Schizophrenia

Edited by

  • John Smythies, Institute of Neurology, National Hospital

Schizophrenia is a severe brain disorder that affects 1% of the population. Its cause is due to the interaction of a number of abnormal genes with environmental factors. This book summarizes new advances schizophrenia research that focus on the field of neural and synaptic plasticity. Synapses in the brain in schizophrenia show a wide range of disorders, both structural and functional. This volume covers the most active and promising of these new developments, and opens up new avenues for the treatment of schizophrenia.
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Neuroscientists, neurologists.


Book information

  • Published: March 2004
  • ISBN: 978-0-12-366860-8

Table of Contents

Loss of Spines and Neuropil; Schizophrenia as a Disorder of Neuroplasticity; The Synaptic Pathology of Schizophrenia: Is Aberrant Neurodevelopment and Plasticity to Blame?; Neurochemical Basis for an Epigenetic Vision of Synaptic Organization; Muscarinic Receptors in Schizophrenia - Is There a Role for Synaptic Plasticity?; Serotonin and Brain Development; Presynaptic Proteins and Schizophrenia; Mitogen-Activated Protein Kinase Signaling; Postsynaptic Density Scaffold Proteins at Excitatory Synapse and Disorders of Synaptic Plasticity: Implications for Human Behavior Pathologies; Prostaglandin Mediated Signaling in Schizophrenia; Mitochondria, Synaptic Plasticity, and Schizophrenia; Membrane Phospholipids and Cytokine Interaction in Schizophrenia; Neurotensis, Schizophrenia and Antipsychotic Drug Action; Schizophrenia, Vitamin D and Brain Development; Possible Contributions of Myelin and Oligodendrocyte Dysfunction to Schizophrenia; Brain Derived Neurotrophic Factor and the Plasticity of the Mesolimbic Dopamine Pathway; S100B in Schizophrenic Psychosis; Oct-6 Transcription Factor; NMDA Receptors, Synaptic Plasticity and Schizophrenia