Diffusion MRI

From quantitative measurement to in-vivo neuroanatomy

Edited by

  • Heidi Johansen-Berg, Oxford Centre for Functional MRI of the Brain (FMRIB), Department of Clinical Neurology, University of Oxford, UK
  • Timothy E.J. Behrens, Department of Experimental Psychology, University of Oxford; Centre for Functional MRI of the Brain (FMRIB), UK

Diffusion MRI is a magnetic resonance imaging (MRI) method that produces in vivo images of biological tissues weighted with the local microstructural characteristics of water diffusion, providing an effective means of visualizing functional connectivities in the nervous system. This book is the first comprehensive reference promoting the understanding of this rapidly evolving and powerful technology and providing the essential handbook for designing, analyzing or interpreting diffusion MR experiments.The book presents diffusion imaging in the context of well-established, classical experimental techniques, so that readers will be able to assess the scope and limitations of the new imaging technology with respect to techniques available previously. All chapters are written by leading international experts and cover methodology, validation of the imaging technology, application of diffusion imaging to the study of variation and development of normal brain anatomy, and disruption to the white matter in neurological disease or psychiatric disorder.
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Neuroscientists interested in the study of connections in the brain, brain imaging, within Cognitive Neuroscience, Neuroscience, Radiology, Medical Physics and adjacent areas.


Book information

  • Published: April 2009
  • ISBN: 978-0-12-374709-9


"A thorough and exciting review of the diffusion MRI techniques that are going to rewrite our knowledge of the long tract anatomy of the human brain. Extremely well written and illustrated." - Michael S. Gazzaniga, Director, Sage Center for the Study of Mind, University of California, Santa Barbara, USA

"25 years after its debut, diffusion MRI today provides us with beautiful, marvelous images of connecting wires within the human brain, and this is achieved just by placing healthy subjects or patients in the middle of a strong magnet. How is this miracle possible? What could we expect from the knowledge of the brain connectome? This beautifully illustrated book addresses these questions with great clarity. The book is highly recommendable to all those who are interested in the links between brain structure and function." - Denis Le Bihan, Member of the Institut de France, Academy of Sciences; Director, NeuroSpin; CEA-Saclay Center, Gif-sur-Yvette, France

"Unbelievable as it may seem, we know almost nothing about the real connectivity of the human cerebral cortex. What we think we know is mostly inferred from results obtained in the monkey. This book provides an exciting exploration of diffusion tensor imaging, a method that can start to close this gap. The editors, who are themselves pioneers in this field, have assembled authoritative chapters on the promises that lie ahead and the challenges that will be encountered." - Marsel Mesulam, Ruth and Evelyn Dunbar Professor of Neurology, Psychiatry and Psychology; Director, The Cognitive Neurology and Alzheimer's Disease Center (CNADC), Feinberg School of Medicine, Northwestern University, Chicago, USA

"Diffusion MRI has tremendous potential for elucidating brain structure and circuitry in health and disease, but the approach is fraught with methodological and interpretational challenges. This excellent and authoritative book edited by Johansen-Berg and Behrens is an invaluable resource for everyone using diffusion MRI or wanting to learn more about it."  - David C. Van Essen, Edison Professor and Department Head, Anatomy and Neurobiology Department, Washington University School of Medicine, St. Louis, USA

Table of Contents

Section 1: Introduction to diffusion MRI1 Introduction to Diffusion MR - Peter J. Basser and Evren Özarslan2 Pulse sequences for diffusion-weighted MRI - James Pipe3 Gaussian modelling of the diffusion signal - Derek K Jones4 Multiple fibres: beyond the diffusion tensor - Kiran K Seunarine and Daniel C AlexanderSection 2: Diffusion MRI for quantitative measurement5 White matter structure: a microscopist’s view - Julia M. Edgar and Ian R. Griffiths6 The biological basis of diffusion anisotropy - Christian Beaulieu7 Inferring microstructural information of white matter from diffusion MRI - Yaniv Assaf and Yoram Cohen8 Cross-Subject Comparison of Local Diffusion MRI Parameters - Steven Smith and Gordon Kindlmann9 Diffusion MRI in neurological disorders - Benedetta Bodini and Olga Ciccarelli10 DTI in development and aging - David Salat, Stephanie Y. Lee, Bindu Setty, H. Diana Rosas and P. Ellen Grant11 Individual differences in white matter microstructure in the healthy brain - Jan Scholz, Heidi Johansen-Berg and Valentina Tomassini12 Diffusion tensor imaging and its application to schizophrenia and related disorders - Martha ShentonSection 3: Diffusion MRI for in-vivo neuroanatomy13 Classic and contemporary neural tract tracing techniques - Robert J. Morecraft, Gabriella Ugolini, José L. Lanciego, Floris G. Wouterlood and Deepak N. Pandya14 The human connectome: linking structure and function in the human brain - Olaf Sporns15 MR diffusion tractography - Timothy E.J. Behrens and Saad Jbabdi16 Validation of tractography - Penny L. Hubbard and Geoffrey J. M. Parker17 Connectivity fingerprinting of grey matter - Johannes C Klein, Timothy E.J. Behrens and Heidi Johansen-Berg18 The connectional anatomy of language: recent contributions from diffusion tensor tractography - Marco Catani19 Tractography for surgical targeting - Andreas J. Bartsch, Armin Biller and György A. Homola20 Comparing brain connections in different species using diffusion weighted imaging - Matthew Rushworth, Erie Boorman and Rogier B. Mars21 Imaging Structure and Function - Saad Jbabdi