Development of T Cell Immunity

Edited by

  • Adrian Liston, Katholieke Universiteit Leuven, Belgium

T cells belong to a group of white blood cells called lymphocytes and play a large role in the immune response. An increased understanding of T cell immunity will provide new insights into the etiology of human autoimmune disease such as diabetes.

This volume reviews the latest developments and discusses the evolution of T cell immunity, thymic requirements, and how to prevent T cell-dependent autoimmunity.

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Audience

Researchers, professors and graduate students in immunology, biochemistry, molecular biology, biotechnology, and medicine.

 

Book information

  • Published: September 2010
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-381284-1

Reviews

PRAISE FOR THE SERIES:
"Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal




Table of Contents

Development of T cell immunity

  1. The development of T cell immunity - Adrian Liston
  2. The evolution of T cell immunity

  3. Genome duplication and T cell immunity - Masanori Kasahara

  • Questions arising from "Genome duplication and T cell immunity" - Claude Perreault
  • Response to questions - Masanori Kasahara

  1. The origin and role of MHC class I-associated self peptides - Claude Perreault

  • Questions arising from "The origin and role of MHC class I-associated self peptides" - Masanori Kasahara
  • Response to questions - Claude Perreault

Thymic requirements for T cell immunity

  1. Transcriptional regulation of thymus organogensis and thymic epithelial cell differentiation - Nancy Manley and Brian Condie
  2. Early T cell differentiation: lessons from T-cell acute lymphoblastic leukemia - Cedric S Tremblay, Thu Hoang and Trang Hoang
  3. T cell immunity in the periphery

  4. Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses - Peter J L Lane, Fiona M McConnell, David Withers, Fabrina Gaspal, Manoj Saini and Graham Anderson

  • Commentary on "Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses" - Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes

  1. Cellular and Molecular Requirements in Lymph Node and Peyer’s Patch Development - Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes
  2. T follicular helper cells during Immunity and Tolerance - Michelle A. Linterman and Carola G. Vinuesa
  3. Preventing T cell-dependent autoimmunity

  4. Thymic selection and lineage commitment of CD4+Foxp3+ regulatory T cells - Paola Romagnoli and Joost P.M. van Meerwijk
  5. Molecular Mechanisms of Regulatory T cell Development and Suppressive Function - Jeong M. Kim

    • Is Foxp3 the master regulator of regulatory T cells? - Adrian Liston