Edited by

  • James Wells, Sunesis Pharmaceutical, Inc., Redwood City, California U.S.A.

Series Editor:

  • Frederic Richards, Yale University, New Haven, Connecticut, U.S.A.
  • David Eisenberg, University of California, Los Angeles, U.S.A.
  • Peter Kim, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute Research Laboratories, Cambridge, U.S.A.

Our most complete understanding of hormone receptor signaling may be exemplified in a family of hormones and receptors known as the cytokine superfamily. This volume is devoted to describing members of this hormone/receptor family from their molecular structures to their physiological effects. These hormones are not only biologically fascinating, but are also tremendously useful medicines.The first three chapters review the basic events in binding and signaling. The remaining papers present the cellular biology and physiological processes controlled by these hormones and receptors.
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Biochemists, molecular biologists, cell biologists, immunologists, endocrinologists, and biomedical researchers.


Book information

  • Published: October 1998
  • ISBN: 978-0-12-034252-5


"The authority, originality, and editing of the reviews are first class."
Praise for the Series, --NATURE

"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."

Table of Contents

N.A. Nicola and D.J. Hilton, General Classes and Functions of Four-Helix Bundle Cytokines.A.A. Kossiakoff and A.M. de Vos, Structural Basis for Cytokine Hormone-Receptor Recognition and Receptor Activation.L. Rocco Carpenter, G.D. Yancopoulos, and N. Stahl, General Mechanisms for Cytokine Receptor Signaling.M. Socolovsky, S.N. Constantinescu, S. Bergelson, A. Sirotkin, and H.F. Lodish, Cytokines in Hematopoiesis: Specificity and Redundancy in Receptor Function.C.M. Silva, J. Isgaard, and M.O. Thorner, Cytokines in Endocrine Function.M.F. Mehler and J.A. Kessler, Cytokines in Brain Development and Function.Subject Index.Author Index.