Current Concepts in Drug Metabolism and Toxicology

Edited by

  • Gabrielle M. Hawksworth

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.
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Audience

Pharmacologists, immunologists, and biochemists

 

Book information

  • Published: June 2012
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-398339-8


Table of Contents

  1. Membrane Transporters in Drug Development
  2. J.P.  Keogh

  3. The Keap1-Nrf2 Cell Defence Pathway - A Promising Therapeutic Target?
  4. Ian M. Copple

  5. Animal Models of Idiosyncratic Drug Reactions
  6. Winnie Ng, Alexandra R.M. Lobach, Xu Zhu, Xin Chen, Feng Liu, Imir G. Metushi, Amy Sharma, Jinze Li, Ping Cai, Julia Ip, Maria Novalen, Marija Popovic, Xiaochu Zhang, Tadatoshi Tanino, Tetsuya Nakagawa and Jack Uetrecht.

  7. Genetic Polymorphisms Affecting Drug Metabolism: Recent Advances and Clinical Aspects
  8. Ann K. Daly

  9. Arylamine N-Acetyltransferases - from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention
  10. Oliver J. Rando

  11. Human Pluripotent Stem Cells for Modelling Toxicity
  12. R.L.C. Sison , R. Kia, J. Heslop, L. Kelly, C. Rowe, M. J. Cross, N. R. Kitteringham, N. Hanley, B. K.Park and C.E.P. Goldring

  13. Disposition of Biologics

Kevin Brady and Rob Webster