Current Challenges in Personalized Cancer Medicine book cover

Current Challenges in Personalized Cancer Medicine

Edited by
  • Keiran Smalley

For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease.

Audience
Pharmacologists, immunologists, and biochemists

Included in series
Advances in Pharmacology

Hardbound, 576 Pages

Published: September 2012

Imprint: Academic Press

ISBN: 978-0-12-397927-8

Contents

    1. Vertical pathway targeting in cancer therapy
      David Shahbazian, Joshua Sznol and Harriet M. Kluger

    2. Histone Deacetylases (HDACs) as Mediators of Resistance to Apoptosis in Melanoma and as Targets for Combination Therapy with Selective BRAF Inhibitors
      Fritz Lai, Lei Jin, Stuart Gallagher, Branka Mijatov, Xu Dong Zhang and Peter Hersey

    3. Targeting the tumor stroma as a novel treatment strategy for breast cancer - shifting from the neoplastic cell-centric to a stroma-centric paradigm
      Julia Tchou, Jose Conejo-Garcia

    4. Targeting the Metabolic Microenvironment of Tumors
      Kate M. Bailey, Jonathan W. Wojtkowiak, Arig Ibrahim Hashim and Robert J. Gillies

    5. Targeted Therapy for Matastasis
      Michael A. Davies

    6. Emerging Strategies for Targeting Cell Adhesion in Multiple Myeloma
      Rajesh R Nair, Anthony W Gebhard, Michael F Emmons and Lori A Hazlehurst

    7. Targeting Notch Signaling for Cancer Therapeutic Intervention
      Hongwei Shao, Qinghua Huang and Zhao-Jun Liu

    8. Stem-like cells and therapy resistance in squamous cell carcinomas
      Nicole Facompre, Hiroshi Nakagawa and Meenhard Herlyn, Devraj Basu

    9. Targeting the tumor stroma as a novel therapeutic approach for prostate cancer
      Omar E. Franco

    10. Resistance to chemotherapy: short-term drug tolerance and stem cell-like subpopulations
      Kevin J. Basile and Andrew E. Aplin

    11. Intratumoral Heterogeneity as a Therapy Resistance Mechanism: Role of Melanoma Subpopulations
      Rajasekharan Somasundaram, Jessie Villanueva and Meenhard Herlyn

    12. Chemoprevention of Melanoma
      SubbaRao V. Madhunapantula and Gavin P. Robertson

    13. Whole genome and exome sequencing of melanoma: a step toward personalised targeted therapy
      Ken Dutton-Regester and Nicholas K. Hayward

    14. Targeted Therapy for Gastric Adenocarcinoma
      Khaldoun Almhanna

    15. HSP90 Inhibitors for Cancer Therapy and Overcoming Drug Resistance
      Komal Jhaveri and Shanu Modi

    16. Apoptosis in Targeted Therapy Responses: The Role of BIM
      Anthony C. Faber, Hiromichi Ebi, Carlotta Costa and Jeffrey A. Engelman

     

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