Current Challenges in Personalized Cancer Medicine
Edited by- Keiran Smalley
For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease.
Audience
Pharmacologists, immunologists, and biochemists
Advances in Pharmacology
Hardbound, 576 Pages
Published: September 2012
Imprint: Academic Press
ISBN: 978-0-12-397927-8
Contents
- Vertical pathway targeting in cancer therapy
David Shahbazian, Joshua Sznol and Harriet M. Kluger - Histone Deacetylases (HDACs) as Mediators of Resistance to Apoptosis in Melanoma and as Targets for Combination Therapy with Selective BRAF Inhibitors
Fritz Lai, Lei Jin, Stuart Gallagher, Branka Mijatov, Xu Dong Zhang and Peter Hersey - Targeting the tumor stroma as a novel treatment strategy for breast cancer - shifting from the neoplastic cell-centric to a stroma-centric paradigm
Julia Tchou, Jose Conejo-Garcia - Targeting the Metabolic Microenvironment of Tumors
Kate M. Bailey, Jonathan W. Wojtkowiak, Arig Ibrahim Hashim and Robert J. Gillies - Targeted Therapy for Matastasis
Michael A. Davies - Emerging Strategies for Targeting Cell Adhesion in Multiple Myeloma
Rajesh R Nair, Anthony W Gebhard, Michael F Emmons and Lori A Hazlehurst - Targeting Notch Signaling for Cancer Therapeutic Intervention
Hongwei Shao, Qinghua Huang and Zhao-Jun Liu - Stem-like cells and therapy resistance in squamous cell carcinomas
Nicole Facompre, Hiroshi Nakagawa and Meenhard Herlyn, Devraj Basu - Targeting the tumor stroma as a novel therapeutic approach for prostate cancer
Omar E. Franco - Resistance to chemotherapy: short-term drug tolerance and stem cell-like subpopulations
Kevin J. Basile and Andrew E. Aplin - Intratumoral Heterogeneity as a Therapy Resistance Mechanism: Role of Melanoma Subpopulations
Rajasekharan Somasundaram, Jessie Villanueva and Meenhard Herlyn - Chemoprevention of Melanoma
SubbaRao V. Madhunapantula and Gavin P. Robertson - Whole genome and exome sequencing of melanoma: a step toward personalised targeted therapy
Ken Dutton-Regester and Nicholas K. Hayward - Targeted Therapy for Gastric Adenocarcinoma
Khaldoun Almhanna - HSP90 Inhibitors for Cancer Therapy and Overcoming Drug Resistance
Komal Jhaveri and Shanu Modi - Apoptosis in Targeted Therapy Responses: The Role of BIM
Anthony C. Faber, Hiromichi Ebi, Carlotta Costa and Jeffrey A. Engelman
- Vertical pathway targeting in cancer therapy

