Control of Messenger RNA Stability

Edited by

  • Joel Belasco, Harvard Medical School, Boston, Massachusetts, U.S.A.
  • George Brawerman, Tufts University, Boston, Massachusetts, U.S.A.

This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression.@introbul:Key Features@bul:* Provides perspectives from both prokaryotic and eukaryotic systems* Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression* Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation* Evaluates experimental procedures for studying mRNA degradation@text:Written by experts in the field, Control of Messenger RNA Stability serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists.
View full description


Book information

  • Published: April 1993
  • ISBN: 978-0-12-084782-2

Table of Contents

Prokaryotes. Mrna Degradation in Prokaryotic Cells: An Overview. The Role of the 3' End in Mrna Stability and Decay. 5'mrna Stabilizers. RNA Processing and Degradation By Rnase E and Rnase K. RNA Processing and Degradation By Rnase III. Translation and Mrna Stability in Bacteria: A Complex Relationship. Eukaryotes. Mrna Degradation in Eukaryotic Cells: An Overview. Hormonal and Developmental Regulation of Mrna Turnover. Control of the Decay of Labile Proto-Oncogene and Cytokine Mrnas. Translationally Coupled Degradation of Tubulin Mrna . Iron Regulation of Tranferrin Receptor Mrna Stability. Degradation of a Non-Polyadenylated Messenge: Histone Mrna Decay. Mrna Turnover in Saccharomyces Cerevisiae. Control of Mrna Degradation in Organelles. Control of Poly(A) Length. Mrna Decay in Cell-Free Systems. Eukaryotic Nucleases and Mrna Turnover. Experimental Approaches to the Study of Mrna Decay. Subject Index.