Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds

Edited by

  • M. Anders, University of Rochester; Department of Pharmacology, New York, U.S.A.
  • Wolfgang Dekant, Universitat Wurzburg

Series Editor:

  • J. August, John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.
  • Ferid Murad, University of Texas Medical School, Houston, U.S.A.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.This special volume of Advances in Pharmacology features a two-color dust jacket.
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Audience

Researchers in biochemistry, bioorganic chemistry, medicinal and pharmaceutical chemistry, pharmacology, and toxicology.

 

Book information

  • Published: May 1994
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-032927-4

Reviews

"The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading."
Praise for the Serial, --JOURNAL OF PHARMACEUTICAL SCIENCES



Table of Contents

J.A. Miller and Y.-J. Surh, Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds.Glutathione-Dependent Toxicity:C. Andersson, E. Mosialou, R. Weinander, and R. Morgenstern, Enzymology of Microsomal Glutathione S-Transferase.B. Ketterer and L.G. Christodoulides, Enzymology of Cytosolic Glutathione S-Transferases.A.J.L. Cooper, Enzymology of Cysteine S-Conjugate b-Lyases.W. Dekant, S. Vamvakas,and M.W. Anders, Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate b-Lyase Pathway.T.A. Baille and K. Kassahun, Reversibility in Glutathione-Conjugate Formation.T.J. Monks and S.S. Lau, Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites.F.P. Guengerich, Metabolism and Genotoxicity of Dihaloalkanes.R. Munday, Bioactivation of Thiols by One-Electron Oxidation.N. Ballatori, Glutathione Mercaptides as Transport Forms of Metals.Sulfate Conjugate-Dependent Toxicity:C.N. Falany and T.W. Wilborn, Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation.C.J. Michejda and M.B.K. Koepke, Carcinogen Activation by Sulfate Conjugate Formation.Glucuronide Conjugate-Dependent Toxicity:K.W. Bock UDP-Glucuronsyltransferases and Their Role in Metabolism and Disposition of Carcinogens.P. Zia-Amirhosseini, H. Spahn-Langguth, and L.Z. Benet, Bioactivation of Glucuronide-Conjugate Formation. Bioactivation and Bioconversion:P.E. Hanna, N-Acetyltransferases, O-Acetyltransferases, and N,O-Acetyltransferases: Enzymology and Bioactivation.M.W. Anders and W. Dekant, Aminoacylases.J.L. Hoffman, Bioactivation by S-Adenosylation, S-Methylation, or N-Methylation.S. Vamvakas and M.W. Anders, Bioconversion of Prodrugs by Conjugate-Processing Enzymes.Subject Index.