Comprehensive Sampling and Sample Preparation

Analytical Techniques for Scientists


  • Janusz Pawliszyn, University Professor and Canada Research Chair, Department of Chemistry, University of Waterloo, Ontario

Section Editor:

  • Josep Bayona, International Journal of Environmental Chemistry
  • Paola Dugo, Full professor of Food Chemistry at the University of Messina
  • X. Chris Le, Distinguished University Professor, jointly appointed in the Departments of Laboratory Medicine and Pathology, Chemistry, and Public Health Sciences, University of Alberta (Canada). Inaugural Canada Research Chair in Bio-Analytical Technology and Environmental Health Fellow of the Royal Society of Canada, Academy of Science. Fellow of Chemical Institute of Canada.
  • Hian Kee Lee, Professor in the Department of Chemistry, National University of Singapore (NUS).
  • Xing-Fang Li, Professor at the University of Alberta (Canada)
  • Heather Lord

Comprehensive Sampling and Sample Preparation is a complete treatment of the theory and methodology of sampling in all physical phases and the theory of sample preparation for all major extraction techniques. It is the perfect starting point for researchers and students to design and implement their experiments and support those experiments with quality-reviewed background information.

In its four volumes, fundamentals of sampling and sample preparation are reinforced through broad and detailed sections dealing with Biological and Medical, Environmental and Forensic, and Food and Beverage applications. The contributions are organized to reflect the way in which analytical chemists approach a problem. It is intended for a broad audience of analytical chemists, both educators and practitioners of the art and can assist in the preparation of courses as well in the selection of sampling and sample preparation techniques to address the challenges at hand. Above all, it is designed to be helpful in learning more about these topics, as well as to encourage an interest in sampling and sample preparation by outlining the present practice of the technology and by indicating research opportunities.

View full description


Educators and practitioners of analytical chemistry as well as researchers and graduate students of analytical chemistry, medicine, environmental science, biochemistry, pharmacology, geology, and food science.


Book information

  • Published: June 2012
  • ISBN: 978-0-12-381373-2

Table of Contents

Volume 1 - Sampling Theory and Methodology

  1. Theoretical approaches
  2. Methodologies for sample preservation & stabilization
  3. Assessing and controlling sample contamination
  4. Homogenisation techniques
  5. Process control sampling
  6. Integrated total analysis systems
  7. Nanomaterials
  8. Indoor air sampling
  9. Exposure asessment workplace
  10. Aerosols PM10 & PM2.5
  11. Passive sampling atmospheric organic contaminants
  12. Surface microlayer
  13. Equipment for water sampling including sensors
  14. Passive sampling organic contaminants in waters
  15. Passive sampling for inorganic contaminants in water
  16. Seawater organic contaminants
  17. Sampling approaches for trace elements determination in seawater
  18. Sampling of Humic and Colloidal Phases in Liquid Samples
  19. Sampling of fish, benthic species and seabird eggs in pollution assessment
  20. Food contaminants
  21. Human biomonitoring for exposure assessment to chemical substances
  22. Biopsic sampling (cancer)
  23. Legal and forensic sampling

Volume 2 - Theory of Extraction Techniques

  1. Theory of Extraction
  2. Headspace analysis
  3. Liquid-Liquid Extraction: Basic Principles and Automation
  4. Soxhlet Extraction and new developments such as Soxtec
  5. Soxhlet Extraction versus Accelerated Solvent Extraction
  6. Accelerated solvent extraction (ASE) and high-temperature water extraction
  7. Fundamentals of Supercritical Fluid Extraction
  8. Microwave extraction
  9. Solvent Microextraction
  10. Dispersive Liquid Liquid Microextraction
  11. Ionic Liquids
  12. Sorbent chemistry, evolution
  13. Sorbents for gas sampling
  14. Principles and Practice of Solid-Phase Extraction
  15. Matrix Solid Phase Dispersion
  16. Sol-Gel sorbents
  17. Molecularly imprinted polymers
  18. Monoliths, fundamentals for sample prep
  19. Bioaffinity sorbents
  20. Nanomaterials for Sample Preparation
  21. Solid Phase Microextraction
  22. Membrane extraction, general overview and basic techniques
  23. Liquid phase microextraction
  24. Membrane Inlets for Mass Spectometry
  25. Microdialysis Sampling in the Brain: Analytical Approaches and Challenges
  26. Analytical derivatization techniques
  27. GC automation
  28. LC automation
  29. Column switching sample preparation
  30. Fundamentals and Applications of Needle Trap Devices
  31. Validation and Regulatory Issues for Sample Preparation

Volume 3 - Extraction Techniques and Applications: Biological/Medical and Environmental/Forensics

  1. General considerations when dealing with biological fluid samples
  2. Considerations on dealing with tissues in a biospecimen collection: Influence of Preanalytical Variables in Biomarker Discovery
  3. Cell separation, Perfusion from tissue, Organelle fractionation
  4. Tissue preparation for microscopy and histology
  5. Blood sample collection and handling
  6. Urine sample collection and handling
  7. Clinical Immunoassays and Immunosensing
  8. the preparation and analytical applications of quantum dots
  9. New born screening of genetic diseases
  10. Issues and pitfalls in biomarker development and clinical relevance
  11. DNA damage, repair, and genome instability (including affinity techniques)
  12. Proteolytic digestion methods for shotgun proteomics
  13. Microwave Digestion of Protein Samples for Proteomics Applications
  14. Selective enrichment of phosphopeptides using nanomaterials and monolithic materials for the analysis of protein phosphorylation
  15. Sample preparation for glyco proteins
  16. Sample prep for single molecule enzyme assays
  17. Sampling and Sample preparation for LC-MS-based metabonomics/metabolomics of samples of mammalian origin
  18. Saliva, serum and tissue samples for proteomic analysis of head and neck cancer
  19. Pre-concentration and sample treatment techniques for trace element analysis
  20. Enzyme treatment of biological samples for speciation
  21. Enzyme digestion for speciation of arsenic
  22. Mercury Speciation and Binding to Biomolecules
  23. Speciation of Cd and binding to phytochelatin
  24. Bioaccessibility assessment
  25. Application of SPME to Pharmacodynamics,
  26. New materials for SPME in biological analysis
  27. Sorbent-phase sample preparation in environmental analysis
  28. Recent advances in sample preparation for pesticide analysis
  29. Membrane-base extractions for environmental analyses
  30. Chemical warfare agents: development and applications of sample preparation approaches
  31. Sample Pretreatment Techniques for Perfluorinated Compounds
  32. Recent advances in solid-phase microextraction for environmental applications
  33. Environmental applications of cloud point extraction
  34. Sample Preparation of Complex Biological Samples in the Analysis of Trace Level Contaminants
  35. Sample preparation for capillary electrophoretic applications
  36. Sample Preparation of Microbial Contaminants in Water
  37. Inorganic contaminants: sample preparation approaches
  38. Advances in sample preparation of environmental solid matrices
  39. Environmental and biological applications of stir bar sorptive extraction
  40. Sample preparation for food contaminant analysis
  41. Liquid-based microextraction techniques for environmental analysis
  42. Sample preparation for chromatographic applications in forensic science
  43. Recent advances in solid-phase microextraction for forensic applications
  44. Recent advances in sample preparation for explosives
  45. Needle trap devices for environmental sample preparation
  46. Use of unconventional solvents for sample preparation in environmental analysis
  47. Preparative gas chromatography as a sample preparation approach

Volume 4 - Extraction Techniques and Applications: Food and Beverage

  1. Headspace sampling in flavour and fragrance field
  2. Chemistry of Volatile Components of Grape Juice, Wine and Alcoholic Beverages
  3. Sampling and sample preparation techniques for the determination of the volatile components of milk and dairy products
  4. Sampling techniques for the determination of volatile components in food of animal origin
  5. Sampling techniques for the determination of the volatile fraction of honey
  6. Sample preparation for food flavor analysis (flavors/off flavors)
  7. In Vivo Sampling of Flavor Components
  8. Extraction techniques for the determination of phenolic compounds in food
  9. Extraction techniques for the determination of carotenoids and vitamins in food
  10. Sampling techniques for the determination of fats in food
  11. Sample preparation for the determination of carbohydrates
  12. Solvent-based extraction techniques for the determination of pesticides in food
  13. Sorbent-based- techniques for the determination of pesticides in food
  14. Sample Preparation Techniques for the Determination of some Food Contaminants (Polycyclic Aromatic Hydrocarbons, Mineral Oils and Phthalates)
  15. Sampling techniques for the determination of migrants from packaging materials in food
  16. Sampling techniques for the determination of micotoxins in food matrices
  17. Sampling techniques for the determination of veterinary drugs in food matrices
  18. Application of SFE in food processing
  19. Accelerated Methods for sample preparation in food
  20. Application of SPE-MIP in the field of food analysis
  21. Application of stir bar sorptive extraction in food analysis
  22. Sample preparation for the determination of metals in food samples
  23. Membrane-based extraction techniques in food analysis
  24. Sample preparation for direct MS analysis of food