Comprehensive Sampling and Sample Preparation book cover

Comprehensive Sampling and Sample Preparation

Analytical Techniques for Scientists

Comprehensive Sampling and Sample Preparation is a complete treatment of the theory and methodology of sampling in all physical phases and the theory of sample preparation for all major extraction techniques. It is the perfect starting point for researchers and students to design and implement their experiments and support those experiments with quality-reviewed background information.

In its four volumes, fundamentals of sampling and sample preparation are reinforced through broad and detailed sections dealing with Biological and Medical, Environmental and Forensic, and Food and Beverage applications. The contributions are organized to reflect the way in which analytical chemists approach a problem. It is intended for a broad audience of analytical chemists, both educators and practitioners of the art and can assist in the preparation of courses as well in the selection of sampling and sample preparation techniques to address the challenges at hand. Above all, it is designed to be helpful in learning more about these topics, as well as to encourage an interest in sampling and sample preparation by outlining the present practice of the technology and by indicating research opportunities.


Educators and practitioners of analytical chemistry as well as researchers and graduate students of analytical chemistry, medicine, environmental science, biochemistry, pharmacology, geology, and food science.

Hardbound, 3200 Pages

Published: June 2012

Imprint: Academic Press

ISBN: 978-0-12-381373-2


  • Volume 1 - Sampling Theory and Methodology

    1. Theoretical approaches
    2. Methodologies for sample preservation & stabilization
    3. Assessing and controlling sample contamination
    4. Homogenisation techniques
    5. Process control sampling
    6. Integrated total analysis systems
    7. Nanomaterials
    8. Indoor air sampling
    9. Exposure asessment workplace
    10. Aerosols PM10 & PM2.5
    11. Passive sampling atmospheric organic contaminants
    12. Surface microlayer
    13. Equipment for water sampling including sensors
    14. Passive sampling organic contaminants in waters
    15. Passive sampling for inorganic contaminants in water
    16. Seawater organic contaminants
    17. Sampling approaches for trace elements determination in seawater
    18. Sampling of Humic and Colloidal Phases in Liquid Samples
    19. Sampling of fish, benthic species and seabird eggs in pollution assessment
    20. Food contaminants
    21. Human biomonitoring for exposure assessment to chemical substances
    22. Biopsic sampling (cancer)
    23. Legal and forensic sampling

    Volume 2 - Theory of Extraction Techniques

    1. Theory of Extraction
    2. Headspace analysis
    3. Liquid-Liquid Extraction: Basic Principles and Automation
    4. Soxhlet Extraction and new developments such as Soxtec
    5. Soxhlet Extraction versus Accelerated Solvent Extraction
    6. Accelerated solvent extraction (ASE) and high-temperature water extraction
    7. Fundamentals of Supercritical Fluid Extraction
    8. Microwave extraction
    9. Solvent Microextraction
    10. Dispersive Liquid Liquid Microextraction
    11. Ionic Liquids
    12. Sorbent chemistry, evolution
    13. Sorbents for gas sampling
    14. Principles and Practice of Solid-Phase Extraction
    15. Matrix Solid Phase Dispersion
    16. Sol-Gel sorbents
    17. Molecularly imprinted polymers
    18. Monoliths, fundamentals for sample prep
    19. Bioaffinity sorbents
    20. Nanomaterials for Sample Preparation
    21. Solid Phase Microextraction
    22. Membrane extraction, general overview and basic techniques
    23. Liquid phase microextraction
    24. Membrane Inlets for Mass Spectometry
    25. Microdialysis Sampling in the Brain: Analytical Approaches and Challenges
    26. Analytical derivatization techniques
    27. GC automation
    28. LC automation
    29. Column switching sample preparation
    30. Fundamentals and Applications of Needle Trap Devices
    31. Validation and Regulatory Issues for Sample Preparation

    Volume 3 - Extraction Techniques and Applications: Biological/Medical and Environmental/Forensics

    1. General considerations when dealing with biological fluid samples
    2. Considerations on dealing with tissues in a biospecimen collection: Influence of Preanalytical Variables in Biomarker Discovery
    3. Cell separation, Perfusion from tissue, Organelle fractionation
    4. Tissue preparation for microscopy and histology
    5. Blood sample collection and handling
    6. Urine sample collection and handling
    7. Clinical Immunoassays and Immunosensing
    8. the preparation and analytical applications of quantum dots
    9. New born screening of genetic diseases
    10. Issues and pitfalls in biomarker development and clinical relevance
    11. DNA damage, repair, and genome instability (including affinity techniques)
    12. Proteolytic digestion methods for shotgun proteomics
    13. Microwave Digestion of Protein Samples for Proteomics Applications
    14. Selective enrichment of phosphopeptides using nanomaterials and monolithic materials for the analysis of protein phosphorylation
    15. Sample preparation for glyco proteins
    16. Sample prep for single molecule enzyme assays
    17. Sampling and Sample preparation for LC-MS-based metabonomics/metabolomics of samples of mammalian origin
    18. Saliva, serum and tissue samples for proteomic analysis of head and neck cancer
    19. Pre-concentration and sample treatment techniques for trace element analysis
    20. Enzyme treatment of biological samples for speciation
    21. Enzyme digestion for speciation of arsenic
    22. Mercury Speciation and Binding to Biomolecules
    23. Speciation of Cd and binding to phytochelatin
    24. Bioaccessibility assessment
    25. Application of SPME to Pharmacodynamics,
    26. New materials for SPME in biological analysis
    27. Sorbent-phase sample preparation in environmental analysis
    28. Recent advances in sample preparation for pesticide analysis
    29. Membrane-base extractions for environmental analyses
    30. Chemical warfare agents: development and applications of sample preparation approaches
    31. Sample Pretreatment Techniques for Perfluorinated Compounds
    32. Recent advances in solid-phase microextraction for environmental applications
    33. Environmental applications of cloud point extraction
    34. Sample Preparation of Complex Biological Samples in the Analysis of Trace Level Contaminants
    35. Sample preparation for capillary electrophoretic applications
    36. Sample Preparation of Microbial Contaminants in Water
    37. Inorganic contaminants: sample preparation approaches
    38. Advances in sample preparation of environmental solid matrices
    39. Environmental and biological applications of stir bar sorptive extraction
    40. Sample preparation for food contaminant analysis
    41. Liquid-based microextraction techniques for environmental analysis
    42. Sample preparation for chromatographic applications in forensic science
    43. Recent advances in solid-phase microextraction for forensic applications
    44. Recent advances in sample preparation for explosives
    45. Needle trap devices for environmental sample preparation
    46. Use of unconventional solvents for sample preparation in environmental analysis
    47. Preparative gas chromatography as a sample preparation approach

    Volume 4 - Extraction Techniques and Applications: Food and Beverage

    1. Headspace sampling in flavour and fragrance field
    2. Chemistry of Volatile Components of Grape Juice, Wine and Alcoholic Beverages
    3. Sampling and sample preparation techniques for the determination of the volatile components of milk and dairy products
    4. Sampling techniques for the determination of volatile components in food of animal origin
    5. Sampling techniques for the determination of the volatile fraction of honey
    6. Sample preparation for food flavor analysis (flavors/off flavors)
    7. In Vivo Sampling of Flavor Components
    8. Extraction techniques for the determination of phenolic compounds in food
    9. Extraction techniques for the determination of carotenoids and vitamins in food
    10. Sampling techniques for the determination of fats in food
    11. Sample preparation for the determination of carbohydrates
    12. Solvent-based extraction techniques for the determination of pesticides in food
    13. Sorbent-based- techniques for the determination of pesticides in food
    14. Sample Preparation Techniques for the Determination of some Food Contaminants (Polycyclic Aromatic Hydrocarbons, Mineral Oils and Phthalates)
    15. Sampling techniques for the determination of migrants from packaging materials in food
    16. Sampling techniques for the determination of micotoxins in food matrices
    17. Sampling techniques for the determination of veterinary drugs in food matrices
    18. Application of SFE in food processing
    19. Accelerated Methods for sample preparation in food
    20. Application of SPE-MIP in the field of food analysis
    21. Application of stir bar sorptive extraction in food analysis
    22. Sample preparation for the determination of metals in food samples
    23. Membrane-based extraction techniques in food analysis
    24. Sample preparation for direct MS analysis of food


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