Comprehensive Medicinal Chemistry II
Volume 1: GLOBAL PERSPECTIVE
Edited by- Peter Kennewell, Swindon, UK
This volume provides and educative and authoriative discussions on the drug discovery and development process. It is divided into ten sections and starts with personal recollections on the history and evolution of the drug discovery process. To illustrate the end result of the drug discovery process, a large chapter reviews the major drug introductions over 1993-2003. Subsequent chapters examine the impact of genomic technologies, new sources of drugs and alternatives to animal testing. The next section reviews the roles of enterprise and pharamaceuticals companies, venture capitalists and academic-industrial relations in the drug discovery process. Social and ethical issues are reviewed in the context of assessing health demands in developed, developing countries and also in relation to smaller scale diseases (orphan drugs). Two chapters then review the bioethical and ethical issues facing the pharmaceutical industry. The volume concludes with reviews on funding and regulartion and how intellectual property rights and patents are protected. With such a wide variety of topics this volume will appeal to both scientists and non-scientists who need to understand how and why the pharmaceutical industry works.
Audience
For students and researchers in chemistry, biochemistry, medicinal chemistry and pharmacology and scientists working in the pharmaceutical industries
Hardbound, 881 Pages
Published: November 2006
Imprint: Elsevier
ISBN: 978-0-08-044514-4
Contents
Volume 1 Global Perspective
Historical Perspective and Outlook
1.01 Reflections of a Medicinal Chemist: Formative Years through Thirty-Seven Years Service in
the Pharmaceutical Industry
1.02 Drug Discovery: Historical Perspective, Current Status, and Outlook
1.03 Major Drug Introductions
The Impact of New Genomic Technologies
1.04 Epigenetics
1.05 Personalized Medicine
1.06 Gene Therapy
Sources of New Drugs
1.07 Overview of Sources of New Drugs
1.08 Natural Product Sources of Drugs: Plants, Microbes, Marine Organisms, and Animals
1.09 Traditional Medicines
1.10 Biological Macromolecules
1.11 Nutraceuticals
Animal Experimentation
1.12 Alternatives to Animal Testing
The Role of Industry
1.13 The Role of Small- or Medium-Sized Enterprises in Drug Discovery
1.14 The Role of the Pharmaceutical Industry
1.15 The Role of the Venture Capitalist
1.16 IndustryAcademic Relationships
Drug Discovery: Revolution, Decline?
1.17 Is the Biotechnology Revolution a Myth?
1.18 The Apparent Declining Efficiency of Drug Discovery
Healthcare in the Social Context
1.19 How Much is Enough or Too Little: Assessing Healthcare Demand in Developed Countries
1.20 Health Demands in Developing Countries
1.21 Orphan Drugs and Generics
Ethical Issues
1.22 Bioethical Issues in Medicinal Chemistry and Drug Treatment
1.23 Ethical Issues and Challenges Facing the Pharmaceutical Industry
Funding and Regulation of Research
1.24 The Role of Government in Health Research
1.25 Postmarketing Surveillance
Intellectual Property
1.26 Intellectual Property Rights and Patents
