Comprehensive Handbook of Alcohol Related Pathology

Edited by

  • Victor Preedy, Department of Dietetics, King's College London, UK
  • Ronald Watson, Professor of Health Promotion Sciences, Mel and Enid Zuckerman Arizona College of Public Health and School of Medicine, Tucson, AZ, USA

This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.
View full description


Researchers involved in the field of alcohol-related harm, institutions, libraries, PhD students, clinicians and pathologists.


Book information

  • Published: December 2004
  • ISBN: 978-0-12-564370-2


" excellent addition to a reference library and to the field of addictionology. ...a great reference -- all you want to know in 2005 regarding alcohol and its medical consequences. ...I highly recommed it for researchers in the field and medical libraries." - DOODY'S (2005)

Table of Contents

Contributors xiiiPreface xxixForeword xxxiVolume 1Part I: General Aspects of Alcohol Toxicity, Consumption, and Disease 11. Evolutionary and Historical Aspects of Ethanol Ingestion 3Robert Dudley2. Alcohol Metabolism: General Aspects 15Charles S. Lieber3 Intake of Different Alcoholic Beverages and Life-style and Psychosocial Factors 27John Barefoot and Morten Grønbæk4. Genetic Aspects of Alcohol Metabolism: An Overview 31Stephen J. Marshall and Geoff K. Chambers5. Predictors of Alcohol Consumption 49Kari Poikolainen6. Binge Drinking: Patterns, Explanations, and Policy 59Holly E. Ventura, Chris L. Gibson, J. Mitchell Miller and Alex R. Piquero7. Breath and Blood Alcohol 75Marion Pavlic and Petra Grubwieser8. Effects of Food and Body Composition on Blood Alcohol Levels 87Harold Kalant9. Disposal of Ethanol Carbon Atoms 103M-A. Cornier10. Effect of Alcohol on Water and Sodium Homeostasis 111Ramón Rodrigo and Gonzalo Rivera11. Energy from Alcohol 121Michael J. Haas12. The Mediterranean Diet and the Contribution and Role of Alcohol 135Maria Isabel Covas13. The Role of Alcohol in Injury Deaths 147Philippe Lunetta and Gordon S. Smith14. Death from Alcohol Poisoning 165James A. Crampton and Kathleen Berry15. Alcohol and the Workplace 175Valentino Patussi and Laura Mezzani16. Alcohol Misuse in Adolescents: Epidemiology, Clinical Characteristics,Diagnosis, and Treatment 181Dawn L. Thatcher and Duncan B. Clark17. Alcohol Misuse in Adolescents: Individual Differences, Prevention,Identification, and Intervention 195Rebecca Lebeau-Craven, Holly A. Sindelar, James Murphy and Nancy P. BarnettPreedyVol1_FM.qxd 19/11/04 9:03 PM Page v18. What is the Impact of Alcohol on Learning in University Students? 215Bert Aertgeerts19. The Relationship Between Alcohol Misuse and the Homelessness 221Colleen Clark and Alexander R. Rich20. Alcohol and Sport Activities: Spectator’s Perspective 241Eli Torild Hellandsjo BuPart II: Damage/Disease(i) General Aspects of Pathology 25121. An Overview of Pathologies Occurring in Alcohol Abusers 253Valentino Patussi, Laura Mezzani and Emanuele Scafato22. Gender Differences in Alcohol Pathology 261Joaquim Fernández-Solà, Josep-María Nicolás, Romon Estruch andAlvaro Urbano-Márquez23. Psychological Effects of Alcohol Misuse 279Marc Walter, Gerhard Dammann and Burghard F. Klapp24. The Effect of Alcohol on Quality of Life 295Paul J. Allison25. Alcohol and Road Accidents 309Andrea Fabbri, Giulio Marchesini and Alberto Vandelli26. Trauma and Alcohol 321Richard D. Blondell27. Clinical Implications of Alcohol Misuse for Surgery 337S. Shourie, P.S. Haber, R. Boughton, and K.M. Conigrave28. Fetal Alcohol Spectrum Disorder 349Christina D. Chambers29. Nutritional Status in Alcoholics 361Romon Estruch, Emilio Sacanella, Joaquim Fernández-Solà and Josep-Maria Nicolás30. Alcohol and Body Composition 377Giovanni Addolorato, Carlo Ancona, Esmeralda Capristo, Giovanni Gasbarrini and theAlcohol Related Diseases Study Group31. Beneficial Components of White Wine 387A.A.E. Bertelli32. Polyphenols and Alcohol: Complementary Mechanisms for the ProtectiveEffects of Moderate Wine Consumption 393A. Di Castelnuovo, S. Rotondo and G. de Gaetano33. Overview of ALDH Polymorphism: Relation to Cardiovascular Effects of Alcohol 409Shih-Jiun Yin and Giia Sheun Peng34. Overview on the Effects of Amount and Type of Alcohol on Morbidity and Mortality 425Morten Grønbæk and Lina Steinrud Mørch35. Alcohol-related Mortality in Russia 441A.V. Nemtsov and P.P. Ogurtsov(ii) Organ Damage 46536. Epidemiology and Risk Factors Involved in Alcoholic Liver Disease 467Ulrik Becker37. Polymorphism and Alcoholic Liver Disease 481José María Ladero38. Liver Injury During Alcohol Use and Withdrawal 491Abraham P. Bautista39. Alcohol Consumption and Diabetes Mellitus 501Angelo Avogaro and Antonio Tiengo40. Alcoholic Ketoacidosis 511Hitender Jain and M. Duggal41. Alcohol, Alcoholism and Effects on the Kidney and Kidney Disease 519Judith H. Veis42. Alcohol Intake and the Lower Urinary Tract 527C.P. Arun43. Alcohol and Prostate Cancer 531Katrine Albertsen and Morten Grønbæk44. Oral Health and Alcohol 551Jukka H. Meurman and Riitta SuuronenVolume 245. Alcohol and the Gastrointestinal Tract 557Gerlinde Egerer, Felix Stickel and Helmut K. Seitz46. Alcohol, ALDH2 Genotypes and Intestinal Cancer 571Motoi Murata47. Alcohol and Pancreatitis 577Alexander Schneider, Stephan L. Haas and Manfred V. Singer48. The Skin and Alcohol 599Elisabeth Higgins49. Alcohol, Blood Pressure and Hypertension 607Ian B. Puddey, Renate R. Zilkens and Lawrence J. Beilin50. Alcohol and Stroke 627Douglas A. Dulli and Madeleine C. Geraghty51. Alcoholic Cardiomyopathy 647Michael Sander, Christian von Heymann, Jan Braun,Adrian Borges and Claudia Spies52. Epidemiologic Aspects of ALDH2 Genotypes and Cardiovascular Parameters 659Tomonori Okamura53. Alcoholic Myopathy: Clinical Aspects 671Joaquim Fernández-Solà, Josep-María NicolásRomon Estruch, Emilio Sacanella, Joseph-María Grau andAlvaro Urbano-Márquez54. Alcohol and the Eye: Friend or Foe 693John R. Trevithick and Kenneth P. Mitton55. Marchiafava–Bignami Disease in Alcoholism 713Yahya Çelik56. Peripheral Neuropathy 719Angelo Ammendola and Francesco Bravaccio(iii) Cells, Pathways, Interactions, Processes 73357. Defects in Methionine Metabolism: Its Role in Ethanol-induced Liver Injury 735Kusum K. Kharbanda and Anthony J. Barak58. Roles of Kupffer Cells in Alcoholic Liver Disease 749Yoshiyuki Takei, Nobuyuki Enomoto, Kenichi Ikejima, Shunhei Yamashina,Tsuneo Kitamura and Nobuhiro Sato59. The Role of the Stellate Cell in Alcohol Mediated Tissue Injury 757R.G. Batey and Jianhua Wang60. The Role of T Lymphocytes in the Pathogenesis of Alcoholic Liver Disease 763Q. Cao and R.G. Batey61. Oxidative Stress in Alcoholic Liver Disease: Clinical Studies 775Carmela Loguercio and Alessandro Federico62. The Relationship between Alcohol-induced Apoptosis and Oxidative Stress in the Liver 785Juan Sastre, Juan Bautista Miñana, Federico V. Pallardó and José Viña63. Alcohol and HIV Interactions in the Natural History and Treatment of HIV/AIDS 799Thomas F. Kresina and Laura W. Cheever64. Alcohol and Hepatitis Virus Interactions in Liver Pathology 819Bin Gao65. Moderate Alcohol and Fibrosis in Chronic Viral Hepatitis 833Johan Westin66. Ethanol–Taurine Interactions in the Brain: Mechanisms andPathophysiological Implications 845Jan Albrecht, Magealena Zielinska, Jeffrey W. Allen,Offie P. Soldin and Michael Aschner67. The Effect of Ethanol on Ion Channels in the Brain: A New Look 855Hugh E. Criswell and George R. Breese68. A Nitric Oxide Signaling Pathway Protects the Developing Brain againstAlcohol-induced Neuronal Death 871Ana M. Hutton Kahrberg, Nicholas J. Pantazis, Ross A. McKim and Daniel J. Bonthius69. Signaling Pathways in the Heart and Moderate Alcohol Intake 887Mary O. Gray70. Effects of Alcohol on Vascular Function 901Jocelyn L. Cook and Sandra T. Davidge71. Vascular and Biochemical Effects of Moderate Alcohol Consumption:Mechanisms of Protection Against Cardiovascular Disease 911Asf je Sierksma, Diederick E. Grobbee and Henk F.J. Hendriks72. Alcohol and Xenobiotics in Placenta Damage 921Cleofina Bosco73. Molecular Mechanisms in Fetal Alcohol Syndrome: Shh-signaling 937Sara C. Ahlgren74. The Process of Bacterial Translocation and Implications for Health in Alcoholics 949Valeria Bender Braulio75. Alcohol, Altered Gut Permeability, and Endotoxins 965Alexandr Parlesak76. Hormonal Responses in Alcoholism 979Bernard Campillo77. Alcohol-induced Changes in the GH–IGF Axis 991Charles H. Lang and Robert A. Frost78. Mechanisms in Prostate Damage by Alcohol 1007Jose A. Castro and Gerardo D. Castro79. Signaling Pathways in Human Breast Cells in Response to Alcohol:Mechanisms for Alcohol-induced Breast Cancer 1017Ernest B. Izevbigie80. The Ubiquitin–Proteasome System in Alcohol-Induced Pathology 1027Terrence M. Donohue, Jr. and Samuel W. French81. Alcohol and Alkylating Agents 1041David B. Couch82. DNA Damage Resulting from Alcohol Abuse with Special Referenceto the Brain 1049Philip J. Brooks, Jacob A. Theruvathu and Raghu G. Nath83. Purine Metabolism and the Influence of Alcoholic Beverages 1069Y. Suwa84. The Role of PKC Isozymes in Mediating Responses to Ethanol 1083John S. Ellingson85. Ethanol Modulation of cAMP-dependent Protein Kinase Subunits Activity:Mechanisms and Functional Consequences 1099Anastasia Constantinescu86. Adhesion Molecules and Alcohol Consumption 1113Emilio Sacanella, Romon Estruch, Josep-Maria Nicolás, and Joaquim Fernández-Solá87. Glucose-regulated Stress Proteins (GRPs) and Alcohol 1127Eckhard Mühlbauer and H. Rommelspacher88. Heat Shock Proteins and Alcohol 1141Luisa Schiaffonati89. Role of Oxidative Stress in Alcohol-Induced Mitochondrial Dysfunction 1153Shannon M. Bailey90. Alcohol and Apoptosis 1175Benita L. McVicker, Dean J. Tuma, Amin A. Nanji and Carol A. CaseyVolume 391. Alcohol and Fatty Acid Ethyl Esters 1195Raneem O. Salem and Michael Laposata92. Modification of Proteins by Reactive Ethanol Metabolites:Adduct Structure, Functional and Pathological Consequences 1209Simon Worrall and Geoffrey M. Thiele93. The Effect of Acetaldehyde on Plasma 1223Arthur S. Brecher94. Autoantibodies in Alcohol-related Tissue Diseases 1245Emanuele Albano and Matteo Vidali95. Alcohol-induced Membrane Damage 1253Junko Adachi, Hideyuki Nushida, Yasuhiro Ueno and Victor R. Preedy96. Alcohol Abuse and Eating Disorders 1263Marlene B. Schwartz and Rajita Sinha97. The Relationship Between Obesity and Alcoholic Pathology 1277Daniel Bunout, María Pía De la Maza and Sandra Hirsch98. Protein Deficiency and Alcohol: Interactions and Organ Effects 1289Emilio González-Reimers and Francisco Santolaria-Fernández99. Tryptophan Metabolism and Alcoholism 1303Abdulla A.-B. BadawyPart III: Selective Methods Used in Alcohol Research 1325100. Selective Methods Used in Alcohol Research: Screening in Primary Care – Methodsand Approaches 1327Adam J. Gordon, Joseph Conigliaro and David A. Fiellin101. Psychometric Assessment of Alcohol Use 1347Andrew J. Levine, Steven A. Castellon and Charles H. Hinkin102. Self-reported Intake of Alcohol: Methods and Approaches 1367Ulrik Kesmodel103. Use of the DSM-IV: Methods and Approaches 1383Deborah Hasin and Rachel Y. Waxman104. The Alcohol-related Problems Survey: Developing andTesting a Screening Measure for Older Adults 1403Arlene Fink105. The Rapid Alcohol Problems Screen: Methods and Application 1415Cheryl J. Cherpitel106. Methods for Determining Blood Alcohol Concentration: Current andRetrospective 1429Kate B. Carey and John T.P. Hustad107. Urinary Markers of Alcohol Consumption 1445Anja Kroke and Jutta Dierkes108. Methods for Measuring Genetic Variations in ADHand SLDH Loci: A Practical Approach 1459Stephen J. Marshall, Geoff K. Chambers and Darren Day109. Histological Localization of Alcohol Dehydrogenase: Methods,Approaches and Applications 1475Susana E. Martínez, Sergio Porté, Julia Vaglenova, Xavier Parés and Jaume Farrés110. Assays for Alcohol and Aldehyde Dehydrogenase: Methods,Approaches and Applications 1489Stewart Campbell and Peter M. Timms111. Detecting ADH and ALDH Enzymes in Cells and Tissues using Western Blotting 1501Connie Cheung and Camilla K. Smith Pease112. Use of Selectively Bred Alcohol-preferring Rats to Study AlcoholAbuse, Relapse and Craving 1515R.L. Bell, Z.A. Rodd, J.M. Murphy and W.J. McBride113. Animal Models of Chronic Alcohol-Induced Liver Damage 1535Jason C. Lambert and Gavin E. Arteel114. Acute Ethanol Dosing Regimens: Methods and Approaches 1551Ernest L. Abel115. Use of Isolated Cells in the Study of Ethanol-Induced Hepatotoxicity 1559Dahn L. Clemens116. Animal Models of Fetal Alcohol Syndrome: Methods and Approaches 1573George K. Acquaah-Mensah117. Genetically Engineered Animals in Alcohol Research 1583David F. Werner, Dev Chandra and Gregg E. Homanics118. cDNA Arrays in Alcohol-Related Pathology: Methods and Approaches 1597R.S. Gooch, T.J. Worst, W.M. Freeman and K.E. Vrana119. Practical Methods for Determining mRNA Levels in Alcohol-ExposedTissues and Its Application to Experimental Pathology 1611Tatsuo Nakahara, Ross J. Hunter, Victor R. Preedy, Colin R. Martin, andMatthew E. Reilly120. Diagnosis of Fetal Alcohol Syndrome: Measurement of theFacial Dysmorphology 1619Ernesta M. Meintjes and Tania S. Douglas121. Nuclear Magnetic Resonance: Methods and Application toAlcohol Effects in the Liver 1635Marie-Christine-Beauvieux and Jean-Louis GallisIndex 1651