Coexistence of Neuronal Messengers: A New Principle in Chemical Transmission

Edited by

  • T. Hökfelt
  • K. Fuxe
  • B. Pernow

This excellent volume discusses the coexistence of multiple messengers in neurons and endocrine cells. Leading scientists from the various important fields within neuroscience, physiology and endocrinology, have herein contributed to the analysis of the functional aspects of coexistence. The resulting volume greatly clarifies and summarises current knowledge and opinion and demonstrates admirably the flexibility of function that multiple messenger systems allow. By doing so, the book will educate, stimulate and inspire research initiatives. The volume is dedicated to Ulf von Euler and Nils-Åke Hillarp
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Book information

  • Published: January 1986
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-80762-5

Table of Contents

Preface. Section I - The Concept of Chemical Transmission. 1. Chemical transmission and Dale's principle. 2. Chemical signalling in the nervous system. Section II - Mutiple Messengers - Overview and Evolution Aspects. 3. The diffuse neuroendocrine system: peptides, amines, placodes and the APUD theory. 4. Coexistence of neuronal messengers - an overview. 5. Molecules of intercellular communication in vertebrates, invertebrates and microbes: do they share common origins? Section III - Invertebrates and Developmental Aspects. 6. Convergence of small molecule and peptide transmitters on a common molecular cascade. 7. Transmitter status in cultured sympathetic principal neurons: plasticity, graded expression and diversity. 8. Impulse activity differentially regulates co-localized transmitters by altering messenger RNA levels. 9. Coexistence during ontogeny and transplantation. Section IV - Multiple Peptide Systems. 10. Genetic background for multiple messengers. 11. Multiple chemical messengers in hypothalamic magnocellular neurons. 12. Regulation of multiple peptides in CRF parvocellular neurosecretory neurons: implications for the stress response. Section V - Peripheral Systems. 13. Purines as cotransmitters in adrenergic and cholinergic neurones. 14. The LHRH family of peptide messengers in the frog nervous system. 15. Chemical coding of enteric neurons. 16. Multiple co-existence of peptides and classical transmitters in peripheral autonomic and sensory neurones - functional and pharmacological implications. 17. On the possible roles of noradrenaline, adenosine 5'-triphosphate and neuropeptide Y as sympathetic co-transmitters in the mouse vas deferens. 18. Neuropeptide Y: coexistence with noradrenaline. Functional implications. Section VI - Central Systems. 19. Aspects on the information handling by the central nervous system: focus on cotransmission in the aged rat brain. 20. Morphofunctional studies on the neuropeptide Y/adrenaline costoring terminal systems in the dorsal cardiovascular region of the medulla oblongata. Focus on receptor-receptor interactions in cotransmission. 21. Functional consequences of coexistence of classical and peptide neurotransmitters. 22. Characterization of central neuropeptide Y receptor binding sites and possible interactions with &agr;2-adrenoceptors. 23. Neuropeptide Y receptor interaction with beta-adrenoceptor coupling to adenylate cyclase. 24. Cotransmission at GABAergic synapses. 25. Functional studies of cholecystokinin-dopamine co-existence: electrophysiology and behavior. Section VII - Synthesis. 26. Coexistence of neuronal messengers and molecular selection. Subject Index.