Clinical Immunology: Principles and Practice book cover

Clinical Immunology: Principles and Practice

Expert Consult: Online and Print

Written and edited by international leaders in the field, this book has, through two bestselling editions, been the place to turn for authoritative answers to your toughest challenges in clinical immunology. Now in full color and one single volume, Clinical Immunology: Principles and Practice, 3rd Edition brings you the very latest immunology knowledge -- so you can offer your patients the best possible care. The user-friendly book and the fully searchable companion website give you two ways to find the answers you need quickly... and regular online updates keep you absolutely current.

Audience
Allergy, Immunology, Infectious Disease

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Published: April 2008

Imprint: Mosby

ISBN: 978-0-323-04404-2

Reviews

  • "…the basics of immunology are rapidly expounded with summaries, tables, and diagrams providing a depth of information on immunological mechanisms in an eye-catching format... The editors and contributors are to be congratulated on this work and I would suggest it would be a valuable reference for those working in the field." - British Society for Immunology, May 2009


Contents

  • PART 1: Fundamental Principles of the Immune Response

    1 The human immune response
    2 Organization of the immune system
    3 Innate immunity
    4 Antigen receptor genes, gene products, and co-receptors
    5 The major histocompatibility complex
    6 Antigens and antigen processing
    7 Antigen-presenting cells and antigen presentation
    8 B-cell development and differentiation
    9 T-cell development
    10 Cytokines and cytokine receptors
    11 Chemokines and chemokine receptors
    12 Lymphocyte adhesion and trafficking
    13 T-cell activation and tolerance
    14 Programmed cell death in lymphocytes

    PART 2: Host Defense Mechanisms and Inflammation

    15 Immunoglobulin function
    16 Regulatory T cells
    17 Helper T-cell subsets and control of the inflammatory response
    18 Cytotoxic lymphocyte function and natural killer cells
    19 Host defenses at mucosal surfaces
    20 Complement and complement deficiencies
    21 Phagocytes and phagocyte deficiencies
    22 Mast cells, basophils and mastocytosis
    23 Eosinophils and eosinophilia

    PART 3: Infection and Immunity

    24 Immune response to extracellular bacteria
    25 Immune responses to intracellular bacteria
    26 Immune responses to spirochetes
    27 Immune responses to viruses
    28 I mmune responses to protozoans
    29 Immune responses to helminths

    PART 4: Immunologic Deficiencies

    30 Evaluation of the immunodeficient patient
    31 Infections in the immunocompromised host
    32 Development of the fetal and neonatal immune system
    33 Aging and the immune system
    34 Primary antibody deficiencies
    35 Primary T-cell immunodeficiencies
    36 Inherited disorders of IFN-γ-, IFN-α/β-, and NF-κB-mediated immunity
    37 HIV infection and acquired immunodeficiency syndrome
    38 Immunodeficiency due to congenital, metabolic, infectious,
    surgical, and environmental factors

    PART 5: Allergic Diseases

    39 Pathogenesis of asthma
    40 Management of the asthmatic patient
    41 Rhinitis and sinusitus
    42 Urticaria, angiodema, and anaphylaxis
    43 Allergic reactions to stinging and biting insects
    44 Atopic and contact dermatitis
    45 Food allergy
    46 Eosinophil-associated gastrointestinal disorders (EGID )
    47 Allergic disorders of the eye
    48 Drug hypersensitivity
    49 Occupational and environmental allergic disorders

    PART 6: Systemic Immune Diseases

    50 Mechanisms of autoimmunity
    51 S ystemic lupus erythematosus
    52 Rheumatoid arthritis
    53 Juvenile idiopathic arthritis
    54 Sjögren’s syndrome
    55 Systemic sclerosis
    56 Inflammatory muscle diseases
    57 Spondyloarthritis
    58 Small- and medium-vessel primary vasculitis
    59 Large-vessel vasculitides
    60 Autoinflammatory fever syndromes
    61 Antiphospholipid syndrome

    PART 7: Organ Specific Inflammatory Disease

    62 Immunohematologic disorders
    63 Bullous diseases of the skin and mucous membranes
    64 Myasthenia gravis
    65 Multiple sclerosis
    66 Autoimmune peripheral neuropathies
    67 Immunologic renal diseases
    68 Inflammation and atherothrombosis
    69 Autoimmune thyroid diseases
    70 Diabetes and related autoimmune diseases
    71 Immunologic lung diseases
    72 Sarcoidosis
    73 Immunologic ocular disease
    74 Immunologic disease of the gastrointesinal tract
    75 Inflammatory hepatobiliary cirrhosis

    PART 8: Neoplasia and the Immune System

    76 Lymphoid leukemias
    77 Lymphomas including Hodgkin lymphoma
    78 Monoclonal gammopathies
    79 Tumor immunology and immunotherapy

    PART 9: Transplantation

    80 Concepts and challenges in transplantation: rejection,
    immunosuppression and tolerance
    81 Challenges and potentials of xenotransplantation
    82 Hematopoietic stem cell transplantation for malignant diseases
    83 Stem cell transplantation and immune reconstitution
    in immunodeficiency
    84 Thymic reconstitution

    PART 10: Prevention and Therapy of Immunologic Diseases

    85 Immunoglobulin therapy: replacement and immunomodulation
    86 Gene transfer therapy of immunologic diseases
    87 Glucocorticoids
    88 Nonsteroidal anti-inflammatory drugs
    89 Antihistamines
    90 Immunomodulating pharmaceuticals
    91 Protein kinase antagonists as therapeutic agents for immunological
    and inflammatory disorders
    92 Vaccines
    93 Immunotherapy of allergic disease
    94 Cytokine therapy
    95 Monoclonal antibodies and fusion proteins

    PART 11: Diagnostic Immunology

    96 Assessment of proteins of the immune system
    97 Flow cytometry
    98 Assessment of functional immune responses
    99 Assessment of neutrophil function
    100 Assessment of human allergic diseases
    101 Molecular methods

    Apendices

    1 Selected CD molecules and their characteristics
    2 Laboratory reference values
    3 Chemokines
    4 Cytokines

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