Ciliary Function in Mammalian Development

Edited by

  • Bradley Yoder, University of Alabama, Birmingham, USA

Cilia--the tiny hairlike structures on the surface of cells--have recently been identified as playing a role in a variety of disease and developmental disorders. Absent or defective cilia in certain cells can cause infertility, blindness, kidney disease, and lung disease. This volume presents recent findings in cilia research and current thought on the role of cilia in disease and developmental abnormalities.
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Researchers in cell, developmental, and molecular biology as well as researchers in genetics


Book information

  • Published: December 2008
  • ISBN: 978-0-12-374453-1

Table of Contents

1. Assembly and function of the basal body Susan Dutcher2. Cilia assembly and maintenanceLotte Pedersen and Joel Rosenbaum3. Origin and Evolution of the ciliumPeter Satir, David R. Mitchell, and Gaspar Jekely4. Transport and targeting of ciliary proteinsGregory Pazour and Robert Bloodgood5. Tubulin Modifications and Regulation of Cilia formation and functionJacek Gaertig 6. Ciliary functions in early embryo patterning and axis formation Martina Brueckner7. Cilia mediated control of Wnt signaling activityNicholas Katsanis8. Ciliary function in regulating planar cell polarity of the inner earPing Chen9. Ciliary role in hedgehog signaling activityJeremy Reiter10. Cilia regulation of cell migration during development and tissue repairSoren Christensen11. Cilia involvement in patterning and maintenance of boneRosa Serra and Courtney Haycraft12. IFT in photoreceptor assembly and functionJoe Besharse13. Ciliary dysfunction diseaseNeeraj Sharma and Bradley Yoder