Chronic Pain and Brain Abnormalities


  • Carl Saab, Department of Neuroscience and Department of Neurosurgery, Brown University, Providence, Rhode Island, USA

It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes.
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Researchers and graduate students in pain neuroscience, neurology, neurosurgery, pain management and anesthesiology


Book information

  • Published: August 2013
  • ISBN: 978-0-12-398389-3


"For pain practitioners, clinicians, scientists, therapists, and biomedical engineers, Saab…compiles five chapters that examine chronic pain-related brain abnormalities, their neurophysiological mechanisms, and neurotechnological and theoretical tools used to study them."--Reference & Research Book News, December 2013

Table of Contents

1. Introduction
  Carl Y. Saab
2. Morphological Brain Changes in Chronic Pain: Mystery and Meaning
  Eric Newman, Eric Moulton, Lino Becerra, David Borsook
3. Thalamic Burst Firing in Response to Experimental Pain Stimuli and in Patients with Chronic Neuropathic Pain May Be a Carrier for Pain-Related Signals
  T. M. Markman, C. C. Liu, J. C. Zhang, K. Kobayashi, J. H. Kim, Frederick A. Lenz
4. Central Pain: A Thalamic Deafferentation Generating Thalamocortical Dysrhythmia
  Rodolfo R. Llinas and Kerry Walton
5. Surgical Interventions for Pain
  Daniel M. Aghion, Garth Rees Cosgrove
6. Thalamocortical Abnormalities in Spinal Cord Injury Pain
  Asaf Keller, Radi Al-Masri
7. Discussion
  Carl Y. Saab