Chromatin Structure and Dynamics: State-of-the-Art

Edited by

  • J. Zlatanova, Department of Chemistry & Chemical Engineering, Polytechnic University, New York, NY, USA
  • S.H. Leuba, Department of Cell Biology & Physiology, University Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburg, PA, USA

Biological processes that replicate, preserve and use the genetic information encoded in DNA must operate in the context of chromatin, a highly organized complex of DNA and proteins. These proteins do not merely package the DNA in the tiny volume of the nucleus, but impart the structure the ability to change according to the requirements of the specific process the DNA is involved in. Moreover, chromatin structure is used by the cell to control the activity of DNA. In this volume the basics of chromatin structure and dynamics are presented by established experts in the field.
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Book information

  • Published: April 2004
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-51594-0

Table of Contents

Preface (J. Zlatanova, S.H. Leuba). Chromatin structure and dynamics: a historical perspective (E.M. Bradbury, K.E. van Holde). The core particle of the nucleosome (J.M. Harp, B.L. Hanson, G.J. Bunick). Paradox lost: nucleosome structure and dynamics in the DNA minicircle approach (A. Prunell, A. Sivolob). The linker histones (A. Jerzmanowski). Chromosomal HMG-box proteins (A.A. Travers, J.O. Thomas). The role of HMGN proteins in chromatin function (K.L. West, M. Bustin). HMGA proteins: multifaceted players in nuclear function (R. Reeves, D. Edberg). Core histone variants (J.R. Pehrson). Histone modifications (J.R. Davie). The role of histone variability in chromatin stability and folding (J. Ausió, D.W. Abbott). Nucleosome modifications and their interaction; searching for a histone code(B.M. Turner). DNA methylation and chromatin structure (J. Zlatanova, I. Stancheva, P. Caiafa). Chromatin structure and function: lessons from imaging techniques (D.P. Bazett-Jones, C.H. Eskiw). Chromatin structure and dynamics: lessons from single molecule approaches (J. Zlatanova, S.H. Leuba). Theory and computational modeling of the 30 nm chromatin fiber (J. Langowski, H. Schiessel). Nucleosome remodeling (A.A. Travers, T. Owen-Hughes). What happens to nucleosomes during transcription?(V. Jackson).