Cholinergic Neurotransmission: Functional and Clinical Aspects

Edited by

  • S.-M. Aquilonius
  • P.-G. Gillberg

This international forum, sponsored by the Nobel Foundation, focussed exclusively on cholinergic mechanisms and was inspired by the first meeting of its kind, organized by Professor Edith Heilbronn and her associates some 20 years ago.The Symposium `Cholinergic Neurotransmission: Functional and Clinical Aspects' took place on the Lidingö Island, Stockholm, in August 1989 and the resulting volume encompasses the contributions of a number of invited scientists prominent in the field of cholinergic neuroscience. The main objective was to provide a detailed overview of the cholinergic research-front of today with emphasis on the basic principles indicating the way to clinical applications.The chapters are organized in such a way as to guide the reader from molecular biology through basic cholinergic pharmacology into clinically oriented contributions that bear upon the number of diseases in which altered cholinergic function is pathophysiologically important, e.g. myasthenia gravis and myasthenic syndromes, disorders of movement and dementia as well as cholinergic mechanisms involved in the regulation of pain, mood and sleep.Additionally, a group of scientists provide a summary at the end of each section outlining future research prospects on cholinergic mechanisms in their specific areas of interest.
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Book information

  • Published: October 1990
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-81148-6

Table of Contents

Content: I. Molecules and principles in cholinergic synaptology. 1. Molecular biology of choline acetyltranferase J. Mallet. 2. Structure and function of muscarinic receptors M.I. Schimerlik. 3. Multiple pathways for signal transduction through the muscarinic cholinergic receptor J.H. Brown, I. Trilivas, J. Trejo and E. Martinson. 4. Second-messenger responses associated with stimulation of neuronal muscarinic receptors expressed by a human neuroblastoma SH-SY5Y D.G. Lambert and S.R. Nahorski. 5. Function of nicotinic synapses D. Colquhoun, A.B. Cachelin, C.G. Marshall, A. Mathie and D.C. Ogden. 6. Expression and in vivo amplification of the human acetylcholinesterase and butyrylcholinesterase genes H. Soreq and H. Zakut. II. Cholinergic mechanisms in the peripheral nervous system. A. A neuromuscular transmission. 7. Spontaneous synaptic activity at developing neuromuscular junctions N. Tabti and M. Poo. 8. The basal lamina and stability of the mammalian neuromuscular junction C.R. Slater. 9. Functional morphology of the nerve terminal at the frog neuromuscular junction: recent insights using immunocytochemistry F. Torri Tarelli, F. Valtorta, A. Villa and J. Meldolesi. 10. Functional aspects on quantal and non-quantal release of acetylcholine at the neuromuscular junction S. Thesleff. 11. Mediatophore: a nerve terminal membrane protein supporting the final step of the acetylcholine release process M. Israel and N. Morel. 12. Cell surface ATP(P2y)-purinoceptors trigger and modulate multiple calcium fluxes in skeletal muscle cells J. Häggblad, H. Eriksson and E. Heilbronn. 13. Immunogenetic mechanisms in myasthenia gravis L. Steinman. 14. Newly recognized congenital myasthenic syndromes: I Congenital paucity of synaptic vesicles and reduced quantal release. II High-conductance fast-channel syndrome. III Abnormal acetylcholine receptor (AChR) interaction with acetylcholine. IV AChR deficiency and short channel open-time. A.G. Engel, T.J. Walls, A. Nagel and O. Uchitel. 15. Clinical pharmacokinetics of acetylcholinesterase inhibitors P. Hartvig, L. Wiklund, S.M. Aquilonius and B. Lindström. 16. Synaptic adaption in diseases of the neuromuscular junction P.C. Molenaar. 17. Current treatment of myasthenia gravis P.O. Osterman. 18. Current therapy of the Lambert-Eaton myathenic syndrome H. Lundh, O. Nilsson and I. Rosén. 19. Future prospects of cholinergic research on neuromuscular transmission S. Thesleff, E. Heilbronn, A.G. Engel and P.C. Molenaar. B. Autonomic nervous system. 20. Structural and functional aspects of acetylcholine peptide coexistence in the autonomic nervous system B. Lindh and T. Hökfelt. 21. The impact of muscarinic receptor subtypes on drug development H. Ladinsky. 22. Basic and clinical aspects on cholinergic agents in bladder dysfunction K.-E. Andersson and H. Hedlund. 23. Cholinergic regulation of the endocrine pancreas B. Ahrén, S. Karlsson and S. Lindskog. 24. Prejunctional control of cholinergic nerves in airway smooth muscle exerted by muscarinic, purinergic and glutamergic receptors P. Aas. 25. Future prospects of cholinergic research in the peripheral nervous system T. Bartfai, A. Sundwall, K.-E. Andersson and H. Ladinsky. III. Cholinergic mechanisms in the central nervous system. 26. Human brain: cholinergic pathways M.-M. Mesulam. 27. Cholinergic receptors in the rat and human brain: microscopic visualization J.M. Palacios, G. Mengod, M.T. Vitaró, K.H. Wiederhold, H. Boddeke, F.J. Alvarez, G. Chinaglia and A. Probst. 28. Physiological mechanisms of cholinergic action in the hippocampus J.V. Halliwell. 29. Principal aspects on the regulation of acetylcholine release in the brain G. Pepeu, F. Casamenti, M.G. Giovannini, M.G. Vannucchi and F. Pedata. 30. Functional aspects of acetylcholine-galanin coexistence in the brain C. Consolo, E. Palazzi, R. Bertorelli, C. Fisone, J. Crawley, T. Hökfelt and T. Bartfai. 31. AF64A-induced central cholinergic hypofunction in the rat I. Hanin. 32. Injury and repair of central cholinergic neurons A.C. Cuello, L. Garofalo, D. Maysinger, E.P. Pioro, A. Ribeiro Da Silva. 33. New approaches to clinical and postmortem investigations on cholinergic mechanisms A. Nordberg, A. Adem, L. Nilsson-Håkansson, G. Bucht, P. Hartvig, I. Alafuzoff, M. Viitanen, B. Långström and B. Winblad. 34. The cholinergic system in Alzheimer disease E. Giacobini. 35. Implications of multiple transmitter system lesions for cholinomimetic therapy in Alzheimer's disease V. Haroutunian, A.C. Santucci and K.L. Davis. 36. Positron emission tomography and cholinergic mechanisms: an overview M. Maziere, K. Khalili-Varasteh, J. Delforge, M. Janier, D. Leguludec, C. Prenant and A. Syrota. 37. Spinal cholinergic mechanisms P.G. Gillberg, H. Askmar and S.-M. Aquilonius. 38. Neuropharmacology of amyotrophic lateral sclerosis H. Askmark, S.M. Aquilonius and P.G. Gillberg. 39. An animal model of motor neuron disease in Guinea pigs S.H. Appel, J.I. Engelhardt and K. Jakob. 40. Antimuscarinic drugs in the treatment of movement disorders S. Fahn, R. Burke and Y. Stern. 41. Cholinergic agents in clinical anaesthesiology L. Wiklund and P. Hartvig. 42. Acetylcholine and acetylcholine receptor subtypes in REM sleep generation J. Velazquez-Moctezuma, P.J. Shiromani and J.C. Gillin. 43. Future prospects of research on central cholinergic mechanisms A. Nordberg, S.H. Appel, C.G. Gottfries and M.-M. Mesulam. IV. Achievements in cholinergic research 1969-1989. 44. The cell and molecular biology of the cholinergic synapse: twenty years of progress V.P. Whittaker. 45. Physiological cholinergic functions in the CNS A.G. Karczmar. 46. The synthesis of acetylcholine: twenty years of progress S. Tuĉek. 47. Drug development D.J. Jenden.Imprint: Elsevier Amsterdam