Chesley's Hypertensive Disorders in Pregnancy

Edited by

  • James Roberts, Senior Scientist, Magee-Women's Research Institute and Professor, Department of Obstetrics, Gynecology, and Reproductive Sciences, and Epidemiology University of Pittsburgh, PA, USA
  • F. Cunningham, Professor and Beatrice and Miguel Elias Distinguished Chair in Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, USA
  • Marshall Lindheimer, MD, FACP, Professor Emeritus, Department of Obstetrics and Gynecology and Medicine, and the Committee on Clinical Pharmacology, The University of Chicago, IL, USA

Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, the hypertensive disorders remain marginally studied, and their management is commonly controversial. Chesley’s Hypertensive Disorders in Pregnancy remains one of the beacons to guide this field, recognized for its uniqueness and utility. The Third Edition continues this tradition, focusing on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, not just preeclampsia.
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Book information

  • Published: April 2009
  • ISBN: 978-0-12-374213-1


Reviews of the Second Edition: "Preeclampsia remains a lethal enigma of pregnancy. Encompassing more than just hypertension, it can include abnormalities of platelet behavior and clotting mechanisms and of endothelial, hepatic, and renal function. The first edition of Leon Chesley's Hypertensive Disorders in Pregnancy (1978) was a scholarly monograph, written by a scientist with a passionate interest in the condition. Since then, the number of maternal deaths from preeclampsia and eclampsia per million pregnancies has been halved in developed countries. Nevertheless, preeclampsia, together with eclampsia, remains one of the two most frequently cited causes of maternal death in the West. The second edition is a multiauthored book. The three editors are researchers who have made a particular effort to achieve a degree of homogeneity in the presentation. The contents are divided into six main sections, each overseen by one of the three editors. Each chapter is also coauthored by one of the editors, which has resulted in coherence in the writing among chapters. Most of the chapters begin with a paragraph about how the topic was considered by Chesley that emphasizes the forward-looking and comprehensive nature of his interest... This book is an authoritative compilation of knowledge in the area, with many references from the second half of the 1990s. It should certainly be in the library of every academic department." --The New England Journal of Medicine "This book is useful for investigators and physicians in the field of hypertension in pregnancy. It is a well-documented book and each chapter is written by an expert in the field. 4 stars!" -- Doody

Table of Contents

Chapter 1 Introduction, History, Controversies, and Definitions

Chapter 2 The Clinical Spectrum of Preeclampsia

Chapter 3 Epidemiology of Pregnancy-Related Hypertension

Chapter 4 Genetic Factors in the Etiology of Preeclampsia/Eclampsia

Chapter 5 The Placenta in Normal Pregnancy and Preeclampsia

Chapter 6 Angiogenesis and Preeclampsia

Chapter 7 Metabolic Syndrome and Preeclampsia

Chapter 8 Immunology of Normal Pregnancy and Preeclampsia

Chapter 9 Endothelial Cell Dysfunction and Oxidative Stress

Chapter 10 Animal Models

Chapter 11 Tests to Predict Preeclampsia

Chapter 12 Prevention of Preeclampsia and Eclampsia

Chapter 13 Cerebrovascular (Patho)Physiology in Preeclampsia/Eclampsia

Chapter 14 Cardiovascular Alterations in Normal and Preeclamptic Pregnancy

Chapter 15 Normal and Abnormal Volume Homeostasis

Chapter 16 Agonistic Autoantibody-Mediated Disease

Chapter 17 The Kidney in Normal Pregnancy and Preeclampsia

Chapter 18 Platelets, Coagulation, and the Liver

Chapter 19 Chronic Hypertension and Pregnancy

Chapter 20 Antihypertensive Treatment

Chapter 21 Management