Chesley's Hypertensive Disorders in Pregnancy

Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, the hypertensive disorders remain marginally studied, and their management is commonly controversial. Chesley’s Hypertensive Disorders in Pregnancy remains one of the beacons to guide this field, recognized for its uniqueness and utility. The Third Edition continues this tradition, focusing on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, not just preeclampsia.


Published: April 2009

Imprint: Academic Press

ISBN: 978-0-12-374213-1


  • Reviews of the Second Edition: "Preeclampsia remains a lethal enigma of pregnancy. Encompassing more than just hypertension, it can include abnormalities of platelet behavior and clotting mechanisms and of endothelial, hepatic, and renal function. The first edition of Leon Chesley's Hypertensive Disorders in Pregnancy (1978) was a scholarly monograph, written by a scientist with a passionate interest in the condition. Since then, the number of maternal deaths from preeclampsia and eclampsia per million pregnancies has been halved in developed countries. Nevertheless, preeclampsia, together with eclampsia, remains one of the two most frequently cited causes of maternal death in the West. The second edition is a multiauthored book. The three editors are researchers who have made a particular effort to achieve a degree of homogeneity in the presentation. The contents are divided into six main sections, each overseen by one of the three editors. Each chapter is also coauthored by one of the editors, which has resulted in coherence in the writing among chapters. Most of the chapters begin with a paragraph about how the topic was considered by Chesley that emphasizes the forward-looking and comprehensive nature of his interest... This book is an authoritative compilation of knowledge in the area, with many references from the second half of the 1990s. It should certainly be in the library of every academic department." --The New England Journal of Medicine "This book is useful for investigators and physicians in the field of hypertension in pregnancy. It is a well-documented book and each chapter is written by an expert in the field. 4 stars!" -- Doody


  • Chapter 1 Introduction, History, Controversies, and Definitions

    Chapter 2 The Clinical Spectrum of Preeclampsia

    Chapter 3 Epidemiology of Pregnancy-Related Hypertension

    Chapter 4 Genetic Factors in the Etiology of Preeclampsia/Eclampsia

    Chapter 5 The Placenta in Normal Pregnancy and Preeclampsia

    Chapter 6 Angiogenesis and Preeclampsia

    Chapter 7 Metabolic Syndrome and Preeclampsia

    Chapter 8 Immunology of Normal Pregnancy and Preeclampsia

    Chapter 9 Endothelial Cell Dysfunction and Oxidative Stress

    Chapter 10 Animal Models

    Chapter 11 Tests to Predict Preeclampsia

    Chapter 12 Prevention of Preeclampsia and Eclampsia

    Chapter 13 Cerebrovascular (Patho)Physiology in Preeclampsia/Eclampsia

    Chapter 14 Cardiovascular Alterations in Normal and Preeclamptic Pregnancy

    Chapter 15 Normal and Abnormal Volume Homeostasis

    Chapter 16 Agonistic Autoantibody-Mediated Disease

    Chapter 17 The Kidney in Normal Pregnancy and Preeclampsia

    Chapter 18 Platelets, Coagulation, and the Liver

    Chapter 19 Chronic Hypertension and Pregnancy

    Chapter 20 Antihypertensive Treatment

    Chapter 21 Management


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