Chemistry and Biology of Heparin and Heparan Sulfate

Edited by

  • Hari Garg, Faculty of Medicine, Harvard Medical School, Boston, MA, USA
  • Robert Linhardt, Rensselaer Polytechnic Institute, Troy, New York, USA
  • Charles Hales, Pulmonary and Critical Care unit, Harvard Medical School Massachusetts General Hospital, Boston, USA

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area.
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Chemists, biochemists, medical doctors, researchers, students and practitioners


Book information

  • Published: December 2005
  • Imprint: ELSEVIER
  • ISBN: 978-0-08-044859-6

Table of Contents

1. Structure and Active Domains of Heparin(B. Casu).
2. Structure and Function of Cell Associated and Pericellular Heparan Sulfate Proteoglycans (S.G. Velleman and C. Liu).
3. Methods for Structural Analysis of Heparin and Heparan Sulfate (I. Capila et al.).
4. Synthetic Approach to Define Structure-Activity Relationship of Heparin and Heparan Sulfate(C. Noti, P.H. Seeberger).
5. Biochemical and Pharmacological Rationale for Synthetic Heparin Polysaccharides (J.M. Walenga et al.).
6. Seperation and Sequencing of Heparin and Heparan Sulfate Saccharides (M.A. Skidmore, J.E. Turnbull).
7. Biosynthesis of Heparin and Heparan Sulfate(Shuji Mizumoto et al.).
8. Remodeling of Heparan Sulfate by Extracellular Endosulfatases (Xinbin Ai et al.).
9. Heparan Sulfate Degradation by Heparanases(K.J. Bame).
10. Lysosomal Degradation of Heparin and Heparan Sulfate (P.J. Meikle et al.).
11. Heparin Regulation of the Complement System(Haining Yu et al.).
12. Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins (T. Rudd et al.).
13. Heparin Activation of Serpins (J.A. Huntington).
14. Role of Heparin in Fibroblast Signalling (N.J. Harmer).
15. Role of Anticoagulant Heparan Sulfate in Mammalian Reproduction (A.I. de Agostini et al.).
16. Glycol-Splitting as a Device for Modulating Inhibition of Growth Factors and Heparanase by Heparin and Heparin Derivatives (A. Naggi).
17. Antithrombin Activation and Designing Novel Heparin Mimics (U.R. Desai).
18. Influence of Heparin Chemical Modifications on Its Antiproliferative Properties (H.G. Garg et al.).
19. Mechanisms of Cell Growth Regulation by Heparin and Heparan Sulfate (M.A. Nugent et al.).
20. Heparin and Low Molecular Weight Heparin in Thrombosis and Inflammation: Emerging Link (S.A. Mousa).
21. Basic and Clinical Differences of Heparin and Low Molecular Weight Heparin Treatment (D. Hoppenstead et al.).
22. Perlecan: An Extracellular Matrix Heparan Sulfate Proteoglycan that Regulates Key Events in Vascular Development and Disease (M.G. Kinsella, T.N. Wight).
23. Heparin and Low Molecular Weight Heparins in Clinical Cardiology (M.E. Korkmaz).
24. Heparin-Induced Thrombocytopenia (T.E. Warkentin, W.E. Dager).
25. Role of Heparan Sulfate in Cancer (Dongfang Liu, Ram Sasisekharan).
26. Use of Heparin Preparations in Older Patients(A. Tufano and M.N. Dario Di Minno).
27. Advances in Low Molecular Weight Heparin Use in Pregnancy (A.J. Thomson, I.A. Greer).