Chemical Signalling in the Basal Ganglia

Edited by

  • G.W. Arbuthnott, University of Edinburgh, Edinburgh, UK
  • P.C. Emson, Institute of Animal Physiology and Genetics Research, Cambridge, UK

The contributions in this book span several disciplines and cross between even the wide areas of basal ganglia research which were chosen as topics. Chemical Signalling in the Basal Ganglia is an excellent scientific work, describing the topics clearly and with vision. Themes of current interest in the basal ganglia are discussed in full and with excellent illustrations. Not only the "basalgangliophile", but also the neuroanatomist, neurobiologist, neurologist, and electrophysiologist will find here some important questions answered. New tools are provided with which to tackle the remaining questions, and tried for size on basal ganglia systems.
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Book information

  • Published: November 1993
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-81562-0


...the book comprises well-written and easy to read articles which should satisfy the potential reader...students and researchers will find helpful information
Journal of Chemical Neuroanatomy

Table of Contents

Preface. Part 1. The Sources of the Signals. 1. The cellular framework for chemical signalling in the nucleus accumbens (G.E. Meredith, C.M.A. Pennartz, H.J. Groenewegen). 2. Cholinergic neurons of the rat and primate striatum are morphologically different (J. Yelnik, G. Percheron, C. Francois, A. Garnier). 3. In vivo studies of the postnatal development of rat neostriatal neurons (J. Tepper, F. Trent). 4. GABAergic circuits of the striatum (H. Kita). 5. Convergence of synaptic terminals from the striatum and the globus pallidus onto single neurones in the substantia nigra and the entopeduncular nucleus (J.P. Bolam, Y. Smith, C.A. Ingham, M. von Krosigk, A.D. Smith). 6. Striatal and subthalamic afferents to the primate pallidus: interactions between two opposite chemospecific neuronal systems (L.-N. Hazrati, A. Parent). 7. The distribution of GABAA-benzo-diazepine receptors in the basal ganglia in Huntington's disease and in the quinolinic acid lesioned rat (R.L.M. Faull, H.J. Waldvogel, L.F.B. Nicholson, B.J.L. Synek). 8. Chemical signalling in the basal ganglia in parkinsonism (J. Brotchie, A. Crossman, I. Mitchell, C. Carroll, A. Cooper, N. Hughes, Y. Manuef). Part 2. The Genetic Control of Signalling. 9. Regulation of glutamic acid decarboxylase gene expression in efferent neurons of the basal ganglia (M.-F. Chesselet, M. Mercugliano, J.-J. Soghomonian, P. Salin, Y. Quin, C. Gonzales). 10. Chemical signalling and striatal interneurons (P.C. Emson, S.J. Augood, R. Senaris, G. Guevra Guzman, J. Kishimoto, K. Kadowaki, P. Norris, K.M. Kendrick). 11. Dopamine receptors: structure and function (P.G. Strange). 12. Neuroleptics and striatal neuropeptide gene expression (S.J. Augood, K. Westmore, R.L.M. Faull, P.C. Emson). 13. Neurochemically specialized projection neurons of the striatum respond differentially to psychomotor stimulants (S. Berretta, H.A. Robertson, A.M. Graybiel). 14. Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system (M. Amalric, G.F. Koob). 15. Reward-related activity in monkey striatum and substantia nigra (W. Schultz, P. Apicella, T. Ljungberg, R. Romo, E. Scarnati). 16. The organization of somatosensory activity in dorsolateral striatum of the rat (L.L. Brown, S.M. Feldman). 17. Neurotransmitter receptors and ionic conductances regulating the activity of neurones in substantia nigra pars compacta and ventral tegmental area (M.G. Lacey). 18. The generation of natural firing patterns in neostriatal neurons (C.J. Wilson). 19. Chemical modulation of synaptic transmission in the striatum (P. Calabresi, N.B. Mercuri, G. Bernardi). 20. D1 and D2 dopamine receptor modulation of sodium and potassium currents in rat neostriatal neurons (D.J. Surmeier, S.T. Kitai). 21. The corticostriatal system on computer simulation: an intermediate mechanism for sequencing of actions (J.R. Wickens, G.W. Arbuthnott). 22. The thorny problem of what dopamine does in psychiatric disease (G.W. Arbuthnott, C.A. Ingham). Subject index.