Table of Contents1. IntroductionIncludes a historical perspective of chemical kinetics and basic physical-chemistry information (Boltzmann distribution law, harmonic oscillator, equilibrium constants, etc). 2. Reaction rate lawsDefinition. Factors that influence the rates (nature of the reactants, concentration of the reactants, temperature, light, catalysts, medium).3. Experimental methodsConventional analytical techniques, including procedures for their application in examples of first and second order reactions, complex reactions, and enzyme catalysis. Fast reaction methods, including relaxation techniques, stopped flow, NMR, flash photolysis, single photon counting, time-resolved photoacoustic calorimetry, femtochemistry. Most of these techniques are illustrated with data collected in the authorsâ labs. 4. Rate constants and reaction ordersFirst, second and zero-order reactions, complex reaction mechanisms (parallel, consecutive and reversible reactions), methods to solve kinetic equations (Laplace transforms, matrix, Runge-Kutta, Markov chain, Monte Carlo), simplification of reaction mechanisms (isolation method, pre-equilibrium approximation, steady-state hypothesis).5. Collisions and molecular dynamicsSimple collisions theory, reaction cross-sections, classical trajectories, avoided crossings in potential energy surfaces, molecular dynamics.6. Reactivity in thermalized systemsTransition-state theory, including semi-classical treatments of zero-point energy and tunnelling. Intersecting-state model. 7. Structure-Reactivity RelationshipsLinear and quadratic free-energy relationships, BrÃ¶nsted, Hammett and Taft relationships. Hammond postulate, reactivity-selectivity principle, Ritchie equation. 8.Unimolecular ReactionsLindemann, Hinshelwood and RRKM approaches. 9. Reaction in solutionSolvent effects, diffusion control, reactivity control in solution (internal pressure, ionic strength, hydrostatic pressure). 10. Reactions in surfacesAdsorption, Adsorption isotherms with or without dissociation. Competitive adsorption. Multilayer adsorption. Bimolecular reactions in surfaces. Velocity of adsorption and desorption. Velocity of reaction of adsorbed species. 11. Nucleophilic substitution reactionsSN1 and SN2 reactions. Langford-Gray classification. Methyl transfers in the gas phase and in solution. Shaik-Pross correlation diagrams. 12. Chain reactionsHalogen â molecular hydrogen reactions. Pyrolysis. Combustion and explosions. 13. Acid-base catalysis and proton-transfer reactionsMechanisms (Arrhenius and van't Hoff intermediates). Specific and general acid-base catalysis. Catalytic activity and acid-base strength. Salt effects. Acidity functions. Proton transfer reactions (Eigen mechanism, carbon acids and bases, solvent effects, kinetic isotope effects). 14. Enzyme catalysisMichaelis-Menten mechanism, competition and inhibition, pH and temperature effects. Molecular models of enzyme catalysis. 15. Transitions between electronic statesGolden-Rule of quantum mechanics. Franck-Condon factors. Radiationless transitions. Electronic coupling. 16. Electron transfersSelf-exchange reactions. Marcus theory and ISM. Spin and distance dependence of nonadiabatic electron transfers. Inverted regions. Electron transfers in proteins. Electrochemistry. 17. Fractals, chaos and oscillatory reactions.