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Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release i… Read more
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Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data.
The scope of approaches discussed in this volume is large, ranging from how to measure changes in the movements of individual atoms, to the statistical approaches for mapping electrical activity across the whole brain. Thus, the audience is expected to consist of computational chemists, synthetic and medicinal chemists and biophysicists, physiologists, neuroscientists at all levels, neurologists, psychiatrists and, of course, anesthesiologists
Computational approaches
1. Physical accuracy leads to biological relevance: Best practices for simulating ligand-gated ion channels interacting with general anesthetics
Grace Brannigan and Sruthi Murlidaran
2. Computational approaches for studying voltage-gated ion channels modulation by general anesthetics
Vincenzo Carnevale
3. Anesthetic parameterization
Jerome Henin
4. Pharmacophore QSAR, QM, ONIOM
Edward Bertaccini
5. Kinetic modeling of electrophysiology data
Robert Cantor
Genetics and model organisms
6. General genetic strategies
Philip G. Morgan
7. Worms
Margaret Sedensky
8. Flies
Bruno van Swinderen
9. Tadpoles
Kellie Ann Woll
10. Zebrafish
Victoria Bedell and Julia Dallman
11. Mice
Max Kelz
Photolabeling
12. Mass spect ID of adducts
Kellie Ann Woll
13. Photolabeling protection/competition
Jonathan Cohen
Xenon
14. Xenon-protein interactions
Benjamin Roose and Ivan Dmochowski
15. Xenon gas delivery/recovery procedures
Mervyn Maze
16. Hyperpolarized Xe-129 MRI
Mitchell Albert
17. CT imaging
Andrew McKinstry-Wu
Electrophysiology
18. Native system electrophysiology (slices, cells, in vivo)
Boris Heifets
19. Voltage-gated ion channels (Kv, Nav)
Manuel Covarrubias and Elaine Yang
20. Ligand-gated ion channels
Stuart A. Forman
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