Cardiovascular Development

Advances in Developmental Biology

  • Rolf Bodmer

In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms. Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field.
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Developmental biologists, cardiologists


Book information

  • Published: October 2007
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-53014-1

Table of Contents

1. Heart Development in DrosophilaLi Qian, Jiandong Liu and Rolf Bodmer2. Morphogenesis of the Vertebrate HeartW.M.H. Hoogaars, V.M. Christoffels, and A.F.M. Moorman3. Heart Development and T-box Transcription Factors: Lessons from Avian EmbryosElaine L. Shelton and Katherine E. Yutzey4. Transcriptional Control of Cardiac Boundary FormationAnabel Rojas and Brian L. Black5. Signaling Pathways in Embryonic Heart InductionRosa M. Guzzo, Ann C. Foley, Yessenia M. Ibarra and Mark Mercola6. Islet1 Progenitors in Developing and Postnatal Heart Sylvia Evans7. Role of MicroRNAs in Cardiovascular BiologyEva Sama and Deepak Srivastava8. Divergent Roles of Hedgehog and Fibroblast Growth Factor Signaling in Left-Right Development Judith M. Neugebauer and H. Joseph Yost9. Development of the conduction system: Picking up the paceDina Myers Stroud and Gregory E. Morley10. Transcriptional Control of the Cardiac Conduction SystemShan-shan Zhang and Benoit G. Bruneau11. Genetic dissection of hematopoiesis using Drosophila as a model systemCory J. Evans, Sergey A. Sinenko, Lolitika Mandal, Julian A. Martinez-Agosto, Volker Hartenstein and Utpal Banerjee12. Vascular Development in the ZebrafishJosette Ungos and Brant M. Weinstein13. Development and function of the epicardiumJörg Manner and Pilar Ruiz-Lozano14. Genetics of transcription factor mutationsVijaya Ramachandran and Woodrow Benson15. Human genetics of congenital heart diseaseJeff Towbin