Edited By

  • Michael Crawford, MD, FACC, Professor of Medicine, Associate Chief of Cardiology for Clinical Programs, Division of Cardiology, University of California- San Francisco, CA, USA
  • John DiMarco, MD, PhD, Julian R. Beckwith Professor of Medicine and Director, Cardiac Electrophysiology Laboratory, Cardiovascular Division, University of Virginia Health System, Charlottesville, VA
  • Walter Paulus, MD, PhD, Professor of Cardiac Pathophysiology, Free University Amsterdam, The Netherlands; Associate Director, Cardiovascular Center, Aalst, Belgium

A team of 250 international experts brings clinicians this thoroughly revised and updated New Edition. Its clinically oriented coverage integrates basic science, diagnostic investigations, and therapeutic management into a practical, user-friendly reference on all aspects of cardiovascular medicine. A consistent format throughout parallels the clinical decision making process to make definitive guidance easy to locate and apply. Over 2,360 illustrations, including more than 1,940 full-color photographs, tables, and diagnostic images make techniques and concepts easy to grasp. Plus, a bound-in CD-ROM features all of the book's illustrations for use in PowerPoint® presentations.
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Cardiology and Cardiology Residents


Book information

  • Published: October 2003
  • Imprint: MOSBY
  • ISBN: 978-0-323-02405-1

Table of Contents


1. Pathogenesis of atherosclerosis
Goran Hansson and Jan Nilsson
2. Epidemiology of cardiovascular diseases
Kjell Asplund
3. Risk factors and lifestyle interventions
Konrad Jamrozik
4. Assessment of cardiac risk
Edward Winslow
5. Special problems in the prevention of cardiovascular disease:
Diabetes mellitus type 2
Virgil Brown and Warren Davis
Menopausal women
Virgil Brown and Warren Davis
Nontraditional risk factors for coronary disease
David Waters
6. Therapeutic approaches to the diabetic patient
Mary Ellen Sweeney and David Orchard
7. Physical activity and the cardiovascular system
Calin Maniu, Thomas Flipse, Norman Patton and Gerald Fletcher
8. Therapy of hyperlipidemia
Lori Mosca
9. Special problems in hyperlipidemia therapy:
Child with hypercholesterolemia
Virgil Brown and Warren Davis
Transplant patient
Virgil Brown and Warren Davis
Hypercholesterolemia in the elderly
Virgil Brown and Warren Davis
Elevated lipoprotein(a)
Virgil Brown and Warren Davis
10. Diagnosis of vascular disease
Charles Tegeler and Disya Ratanakorn
11. Arterial diseases of the limbs
Bengt Fagrell
12. Cerebral vascular diseases
Kjell Asplund and Markku Fagerlund
13. Thoracic aorta disease
Jorge Wernly
14. Abdominal aortic aneurysms
Ian Franklin and Roger Greenhalgh
15. Venous disease
Agnes Lee
16. Surgery for vascular disease
David Bergqvist
17. Special problems in vascular disease:
Compromise of an internal thoracic artery to coronary artery graft by subclavian artery disease
Michael Crawford and Mark Langsfeld
Localized lymphedema
Michael Crawford and Mark Langsfeld

1. Physiology of coronary circulation
Eric Feigl and Wolfgang Schaper
2. Coronary artery anomalies
Allen Taylor and Renu Virmani
3. Pathophysiology of myocardial ischemia
PK Shah and Erling Falk
4. Noninvasive diagnosis of IHD
George Beller
5. Invasive diagnosis of IHD
William Kussmaul
6. Special diagnostic issues in IHD:
The patient with chest pain, a positive stress test and normal coronary arteries
Jonathan Abrams
The patient with coronary artery disease and acute heart failure
Jonathan Abrams
The patient with coronary artery disease and chronic heart failure
Jonathan Abrams
7. Chronic stable angina pectoris
Udho Thadani
8. Variant angina pectoris
Juan Kaski and Ramon Arroyo-Espliguero
9. Microvascular angina pectoris and cardiac syndrome X
Hans Erik Botker
10. Asymptomatic myocardial ischemia
Prakash Deedwania
11. Special problems in myocardial ischemia:
Management of variant angina breakthrough
Carl Pepine and Stephen Monroe
Mangement of the nonrevascularization candidate with severe angina
Carl Pepine and Stephen Monroe
Treatment of silent ischemia
Carl Pepine and Stephen Monroe
Treatment of microvascular angina
Carl Pepine and Stephen Monroe
Viagra, sexual activity and the cardiac patient
Jonathan Abrams
12. Diagnosis of acute myocardial ischaemia and infarction
Allan Jaffe, Jorge Davidenko and Ian Clements
13. Unstable angina and non-ST-elevation MI
Lars Wallentin, Bertil Lindahl and Agneta Siegbahn
14. The early phase of acute myocardial infarction
Freek Verheugt
15. Subacute in-hospital phase of ST-segment elevation MI
Timothy Denton
16. Complications of acute MI
Bojan Cercek and PK Shah
17. Surgery for the complications of MI
Carlos Blanche
18. Post-hospital phase of an acute coronary syndrome
Christopher Cannon and Sidney Smith
19. Special problems in acute coronary syndromes:
Right ventricular infarction
Peter Clemmensen
AMI and normal coronary arteries
Peter Clemmensen and Peer Grande
Nonreperfused AMI after thrombolytic therapy
Peter Clemmensen
20. Catheter based techniques to treat IHD
Pim de Feyter
21. Surgery for IHD
Kenton Zehr and Hartzell Schaff
22. Special problems in non-pharmacologic therapy:
Unprotected left main coronary angioplasty
Michael Ragosta
Chronic total occlusion
Michael Ragosta
Saphenous vein graft interventions
Michael Ragosta
Percutaneous intervention of cardiac allograft vasculopathy
Michael Ragosta
In-stent restenosis
Michael Ragosta

1. Etiology and pathogenesis of systemic hypertension
David Calhoun, M. Amin Zaman and Suzanne Oparil
2. Epidemiology of hypertension
Ivan Perry
3. Clinical recognition of hypertension
Shawna Nesbitt, Wanpen Vongpatanasin and Ronald Victor
4. Complications of hypertension: heart
Chim Lang and Greg Lip
5. Complications of hypertension: kidney
Domenic Sica
6. Complications of hypertension: stroke
John Potter
7. Nonpharmacologic treatment of hypertension
Francesco Cappuccio and Alphonso Siani
8. Pharmacologic treatment
S. Luke Kusmirek, Aris Efstratopoulos and George Bakris
9. Hypertension crises
Gareth Beevers and Greg Lip
10. Diagnosis and treatment of secondary hypertension
David Martins and Keith Norris
11. Difficult hypertension management issues:
Hypertension and ethnicity
Greg Lip and Gareth Beevers
Hypertension in pregnancy: pre-eclampsia
David Churchill
Perioperative hypertension
William Elliott
Ambulatory blood pressure monitoring
William White
Diabetes and hypertension
Samy I. McFarlane and James Sowers
Resistant hypertension
Ronald Victor
Hypertension in the context of acute myocardial infarction and acute coronary interventions
Greg Lip
Concomitant therapy use in hypertension
George Bakris

1. Basic cardiac electrophysiology and anatomy
Mark Anderson and Dan Roden
2. Antiarrhythmic drug therapy
Paul Dorian and Wendy Lau
3. Principles of catheter ablation
David Haines
4. Syncope
Andrew Krahn, George Klein, Raymond Yee and Allan Skanes
5. Sinus node dysfunction
John DiMarco
6. Atrioventricular and intraventricular conduction disorders
Nadir Saoudi, Jean Paul Rinaldi, Manuel Imianitoff, Khelil Yaïci, Jean Marc Coutelourd, Marc Bergonzi and Phillipe Ricard
7. Cardiac pacing
Henning Rud Andersen and Jens Cosedis Nielsen
8. Special problems in cardiac pacing:
Pacemaker syndrome
Mark Wood
Temporary cardiac pacing
Mark Wood
Diagnostic and surgical procedures in pacemaker patients
Mark Wood
Pacemaker lead extraction
Mark Wood
Biventricular pacing for congestive heart failure
Mark Wood
9. Supraventricular tachycardia
Carlos Morillo
10. Atrial fibrillation
Greg Lip, Michael Mangram and John DiMarco
11. Atrial flutter and atrial tachycardia
Francis Murgatroyd
12. Pre-excitation syndromes
James Leitch, Pru Hereford Ashley and Malcolm Barlow
13. Special problems in supraventricular arrhythmias:
Syncope in paroxysmal supraventricular tachycardia
Chin-Feng Tsai and Shi-Ann Chen
Paroxysmal atrial fibrillation
Chin-Feng Tsai and Shi-Ann Chen
Cycle length alternation in supraventricular tachycardia
Chin-Feng Tsai and Shi-Ann Chen
Atrial flutter
Bruce Walker
Postoperative atrial fibrillation
Bruce Walker
Atrial Fibrillation and Anticoagulation
Bruce Walker
14. Ventricular tachycardia
Martin Borggreffe, Gunther Breithardt and Christian Wolpert
15. Repolarization syndromes: Long QT, Brugada etc.
Katherine Murray and Dan Roden
16. Sudden cardiac death
Paul LeLorier and Kevin Monahan
17. Cardiac arrest resuscitation
Jose Joglar and Rick Page
18. Surgery for cardiac arrhythmias
Patricia Bakker
19. Implantable defibrillators
Kathy Lee and Chu-Pak Lau
20. Special problems in ventricular arrhythmias:
Multiple shocks from an implanted defibrillator caused by frequent episodes of ventricular tachycardia
John Miller and Mithilesh Das
Multiple shocks from an implanted defibrillator in a supra ventricular arrythmia
John Miller and Mithilesh Das
Syncope in a patient with idiopathic dilated cardiomyopathy
John Miller and Mithilesh Das
A young woman with palpitations and ventricular tachycardia
John Miller and Mithilesh Das
Nonsustained ventricular tachycardia following anterior myocardial infarction
John Miller and Mithilesh Das

1. Physiology of the normal and failing heart
Helmut Drexler and Gerd Hasenfuss
2. Assessment of the patient with heart failure
Ayan Patel and Marvin Konstam
3. Acute heart failure and shock
Steven Hollenberg, Mitchell Saltzberg, Jeffrey Soble and Joseph Parrillo
4. Heart failure due to systolic dysfunction
Gary Francis and Wai Tang
5. Management of the patient with chronic heart failure
Barry Massie
6. Heart failure with normal left ventricular ejection fraction: a manifestation of diastolic dysfunction
William Gaasch and Edgar Schick
7. Arrhythmias in heart failure
Lars Eckardt, Wilhelm Haverkamp, Dirk Bocker and Gunter Breithardt
8. Surgery assist devices and cardiac transplantation for heart failure
James Young
9. Special problems in chronic heart failure:
Mechanisms of exercise intolerance and exercise training
Kai C. Wollert, Helmut Drexler and Andrew Coats
Cardiac cachexia
Kai C. Wollert, Helmut Drexler and Andrew Coats
Renal dysfunction in heart failure
Kai C. Wollert, Helmut Drexler and Andrew Coats
Anemia in Heart Failure
Kai C. Wollert, Helmut Drexler and Andrew Coats
Depression in Heart Failure
Kai C. Wollert, Helmut Drexler and Andrew Coats
Disease Management
Kai C. Wollert, Helmut Drexler and Andrew Coats
10. Myocarditis and inflammatory cardiomyopathy
Heinz-Peter Schultheiss and Uwe Kuehl
11. Dilated and toxic cardiomyopathy
John O'Connell and Mohammad Akkad
12. Hypertrophic cardiomyopathy
Perry Elliott, William McKenna and Sebastian Reith
13. Special problems in myocarditis and cardiomyopathy:
Peripartum cardiomyopathy
Mohammed W. Akhter, Afshan Hameed and Uri ElKayam
Chagas' heart disease
Harry Acquatella
Tachycardia-induced cardiomyopathy
Harry Acquatella
Diabetic cardiomyopathy
Mitchell Saltzburg and Barry Massie
14. Restrictive and infiltrative cardiomyopathies
Naveen Pereira and William Dec, Jr.
15. Pericardial disease
Samer Kabbani and Martin LeWinter
16. Pulmonary hypertension and intrinsic pulmonary vascular disease
Vallerie McLauchlin
17. Right heart failure and cor pulmonale
W. MacNee and K. Skwarski
18. Pulmonary embolism
Stavros Konstantinides and Wolfgang Kasper

1. Non-invasive assessment of valvular function
Otto Smiseth, Reidar Bjornerheim and Sigurd Nitter-Hause
2. Invasive assessment of valvular function
Barbara Julius, Stephan Windecker and Otto Hess
3. Rheumatic fever
Mohammed Essop and Tanvier Omar
4. Mitral stenosis
John Carroll and Julie Plenge
5. Mitral regurgitation
Blase Carabello
6. Mitral valve prolapse
Richard Devereux
7. Secondary mitral regurgitation
Matthew A. Romano, Iva A. Smolens and Stephen F. Bolling
8. Special problems in mitral valve disease:
New onset atrial fibrillation in asymptomatic mitral stenosis
Bernard Iung, Bertrand Cormier and Alec Vahanian
Echocardiography and mitral valve repair: its use in Marfan's syndrome
Bernard Iung, Bertrand Cormier and Alec Vahanian
Thromboembolic risk in mitral stenosis
Bernard Iung, Bertrand Cormier and Alec Vahanian
Mitral stenosis and pregnancy
Bernard Iung, Bertrand Cormier and Alec Vahanian
Radiation Valve Disease
Theo Meyer and Gerard Aurigemma
Vasodilators in mitral regurgitation
Bill Gaasch
9. Aortic stenosis
David Shavelle and Catherine Otto
10. Acute aortic regurgitation
Gerard Aurigemma and Theo Meyer
11. Chronic aortic regurgitation
Walter Paulus
12. Special problems in aortic valve disease:
Low gradient, low output aortic stenosis
Paul Grayburn
Mild-to-moderate aortic stenosis in patients undergoing bypass surgery
Paul Grayburn
fen phen valve disease
Dr. Bruce Shively
13. Tricuspid and pulmonic valve disease
Theo Meyer and Dennis Tighe
14. Infective endocarditis
Jean Acar and Pierre-Louis Michel
15. Surgery for valvular heart disease
Christophe Acar and Pierre Theodore
16. Management of the post surgical valve disease patient
Patrick Parrino, Aditya Kaza and John Kern
17. Special problems in the surgically treated valve disease patient:
How to treat perivalvular leaks
Sandro Betocchi, Maria Angela Losi and Massimo Chiariello
Pregnancy and anticoagulants
Sandro Betocchi, Maria Angela Losi and Massimo Chiariello
Postoperative management of myocardial dysfunction in valvular surgical treatment
Sandro Betocchi, Maria Angela Losi and Massimo Chiariello

1. Epidemiology of congenital heart disease
Cynthia Morris
2. Embryology of congenital heart disease
Adrianna Gittenberger de Groot, Marco Deruiter, Margot Bartelings and Robert Poelmann
3. Prenatal diagnosis of congenital heart disease
Yasuki Maeno
4. Diagnostic pathways for evaluation of congenital heart disease
Tal Geva and Jaqueline Kreutzer
5. Atrial septal defect
Masahiro Ishii
6. Anomalous pulmonary venous connection
Samuel Ritter and Rebecca Snider
7. Ventricular septal defect
Kimberly Krabill
8. Tetralogy of Fallot and truncus arteriosus
Kazuo Momma
9. Transposition of the great arteries
Thomas Kimball
10. Pulmonary atresia with ventricular septal defect
Daniel Murphy and Roger Mee
11. Left heart outflow obstructions
Gautam Singh and Syamasunder Rao
12. Hypoplastic left heart syndrome
Girish Shirali and Constance Cephus
13. Ebstein's anomaly
Robin Shaughnessy
14. Pulmonary stenosis
Teiji Akagi
15. Pulmonary Atresia with Intact Ventricular Septum
Frank Smith
16. Atrioventricular canal defects
Craig Fleishman and Gerald Marx
17. Tricuspid atresia and single ventricle
Luc Mertens and Donald Hagler
18. Patent ductus arteriosis
Dierk Redel
19. Coarctation of the aorta
Mataichi Ohkubo and Toshihiro Ino
20. Vascular compression of the upper airways
Deane Waldman
21. Kawasaki's disease
Hirohisa Kato
22. Arrhythmias in congenital heart disease
Victoria Vetter
23. Adult congenital heart disease
David Celermajer
24. Special problems in adult congenital heart disease:
Pregnancy in the woman with Eisenmenger syndrome
George Pantely and Victor Menashe
Thromboembolic complications after the Fontan procedure
George Pantely, Mark Morton and Victor Menashe
Late systemic right ventricular failure in transposition of the great arteries
George Pantely and Victor Menashe

1. Chronic renal disease
Nikolaos Kaperonis and George Bakris
2. Obesity
Scott Grundy and Nicola Abate
3. The neurogenic heart
Arturo Tamayo and Vladimir Hachinski
4. Endocrinology and the heart
Sylvia Vela
5. Rheumatologic diseases
Carlos Roldan
Catherine Decker, Peter Sklar and Henry Masur
7. Cardiac tumors
Colette Guiraudon
8. Hematologic disease
Stuart Hutchison and Patrick Disney
9. Neuromuscular disease
Benjamin Sanchez and Ileana Pina
10. Aging and geriatric heart disease
Rose Anne Kenny and Colette Seifer
11. Pregnancy in the heart disease patient
Laura Collins and Pamela Douglas
12. Athletes heart
Barry Maron
13. Psychological influences on the heart
Kristina Orth-Gomer, Margaret Chesney and Gerdie Weidner
14. Trauma
M.L. Myers, A. Cheung and William Sibbald
15. Radiation
Jacob Adams, Louis Constine and Stephen Lipshultz
16. High altitude
Stuart Hutchison
17. Alternative cardiovascular medical therapies
William Kostuk
18. Perioperative evaluation of the cardiac patient
Michael Crawford
19. Surgery and the cardiac patient
Dennis Mangano
20. Employment and insurability
William Dafoe
21. Anticoagulation in heart disease
Michael Ezekowitz, Abhay Dhond and Pavlo Netrebko
22. Special problems for the cardiology consultant:
Cocaine-induced cardiovascular disease
Paul Tanser
Munchausen's syndrome with cardiac manifestations
Paul Tanser
Behavioural modification in cardiac disease with inappropriate disability
Paul Tanser
Peripheral vascular disease as a predictor of significant coronary artery disease
Paul Tanser
Sexual dysfunction in patients with cardiac disease
Paul Tanser
Obesity and heart disease
Paul Tanser
Hypotension during hemodialysis
Michael Crawford