Cardiac Regeneration and Repair

Biomaterials and Tissue Engineering

Edited by

  • Ren-Ke Li
  • Richard D. Weisel, University of Toronto, Canada

Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure.

Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.

Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials.

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Scientists and academic researchers in the areas of cardiac regeneration and repair, tissue engineering, cell therapies, and biomaterials; Cardiovascular doctors, cardiac surgeons, and cardiologists; Stem cell researchers


Book information

  • Published: January 2014
  • Imprint: Woodhead Publishing
  • ISBN: 978-0-85709-659-3

Table of Contents

Part 1 Biomaterials for cardiac regeneration and repair: Nanotechnology and nanomaterials for cardiac repair; Hydrogels for cardiac repair; Injectable biomaterials for cardiac regeneration and repair; Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration; Endothelial progenitor cell (EPC)-seeded intravascular stents. Part 2 Tissue engineering for cardiac regeneration and repair: Biomaterials and cells for cardiac tissue engineering; Decellularized biologic scaffolds for cardiac repair and regeneration; Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix; Cell sheet engineering for cardiac repair and regeneration; Maturation of functional cardiac tissue patches; Vascularizing engineered tissues for in vivo and in vitro applications; Clinical considerations for cardiac tissue engineering. Part 3 Vascular remodelling for regeneration and repair: Aortic extra cellular matrix (ECM) remodelling; Cell-biomaterial interactions for blood vessel formation; Stem cells in tissue-engineered blood vessels for cardiac repair; Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (TESA™).