Cardiac Electrophysiology

From Cell to Bedside

By

  • Douglas Zipes, MD, Distinguished Professor, Emeritus Professor of Medicine, Pharmacology, and Toxicology, Emeritus Director, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN; Editor-in-Chief, HeartRhythm, Editor-in-Chief, PracticeUpdate/Cardiology
  • Jose Jalife, MD, Cyrus and Jane Farrehi Professor of Cardiovascular Research,Professor of Internal Medicine, Professor of Molecular and Integrative Physiology, University of Michigan Medical School; Co-Director, University of Michigan Center for Arrhythmia Research, Ann Arbor, Michigan
  • Douglas Zipes, MD, Distinguished Professor, Emeritus Professor of Medicine, Pharmacology, and Toxicology, Emeritus Director, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN; Editor-in-Chief, HeartRhythm, Editor-in-Chief, PracticeUpdate/Cardiology
  • Jose Jalife, MD, Cyrus and Jane Farrehi Professor of Cardiovascular Research,Professor of Internal Medicine, Professor of Molecular and Integrative Physiology, University of Michigan Medical School; Co-Director, University of Michigan Center for Arrhythmia Research, Ann Arbor, Michigan

Here's today's most authoritative and up-to-date information on basic and clinical electrophysiology. The 4th Edition covers everything from fundamental explanations of currents and channels, through the theoretical and experimental bases of cardiac electrical activity and arrhythmias, to current clinical understandings of arrhythmias and their treatment—and features the most comprehensive updating and revision to date.
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Audience

Clinical Electrophysiologists; Electrophysiology Researchers, Cardiology

 

Book information

  • Published: April 2004
  • Imprint: SAUNDERS
  • ISBN: 978-0-7216-0323-0


Table of Contents

PART I: STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION
Chapter 1. Sodium Channels - Eduardo Marban
Chapter 2. Cardiac Calcium Channels - Donald M. Bers
Chapter 3. Voltage Regulated Potassium Channels -
Gavin Y. Oudit, Rafael J. Ramirez and Peter H. Backx
Chapter 4: Intracellular Signaling and Regulation of Cardiac Ion Channels - Anant Khositseth, David E. Clapham, and Michael J. Ackerman
Chapter 5: Membrane Pumps and Exchangers - Larry V. Hryshko
Chapter 6: Sarcoplasmic Reticulum Ion Channels - Gerhard Meissner.
Chapter 7: HCN Channels: From Genes to Function -
Andreas Ludwig, Juliane Stieber, Sven Moosmang, Stefan Herrmann, Martin Biel, Franz Hofmann
Chapter 8: Molecular Organization and Regulation of the Cardiac Gap Junction Channel Connexin43 - Mario Delmar , Heather S. Duffy, Paul Sorgen, Steven M. Taffet, David C. Spray

PART II: BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION
Chapter 9: Biophysics of Normal and Abnormal Cardiac Sodium Channel Function - Jeffrey R. Balser
Chapter 10: Gating of Cardiac Delayed Rectifier K+ Channels - Michael C. Sanguinetti and Martin Tristani-Firouzi
Chapter 11: Heart Mechanoelectric Transduction - Frederick Sachs
Chapter 12: Pacemaker Channels and Normal Automaticity - Dario DiFrancesco
Chapter 13: Biophysical Properties of Inward Rectifier Potassium Channels - Justus Anumonwo
Chapter 14: Homomeric and Heteromeric Gap Junctions - Volodya Hayrapetyan, Guoqiang Zhong, Agustín D. Martínez and Eric C. Beyer. Alonso P. Moreno

PART III: INTERMOLECULAR INTERACTIONS AND PHARMACOLOGY OF CARDIAC ION CHANNELS
Chapter 15: Pharmacology of the Cardiac Na Channel - Jonathan C. Makielski, Bin Ye, Timothy J. Kamp, and Craig T. January
Chapter 16: Pharmacology of L-type and T-type channels in the heart - Xiongwen Chen and Steven R. Houser
Chapter 17: KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease - Sheila Carrol, Junko Kurokawa, and R.S. Kass
Chapter 18: Drug-induced Channelopathies - Charlie Antzelevitch
Chapter 19: Prospects for Pharmacological Targeting of Gap Junction Channels - Miduturu Srinivas, Heather Duffy, Mario Delmar, David C. Spray

PART IV: ION CHANNELS AND CELLULAR ELECTROPHYSIOLOGY
Chapter 20: Heterogeneous expression of Potassium channels - Jeanne M. Nerbonne
Chapter 21: Gap Junction Distribution and Regulation in the Heart - Jeffrey E. Saffitz, Deborah L. Lerner, Kathryn A. Yamada
Chapter 22: Cellular Mechanisms of Sinoatrial Activity - Itsuo Kodama, Haruo Honjo, Halina Dobrzynski, Mark R. Boyett
Chapter 23: Mechanisms of AV nodal Excitability and Propagation - Igor R. Efimov and Vladimir P. Nikolsk
Chapter 24: Intercellular Communication and Impulse Propagation - André G. Kléber
Chapter 25: Cardiac tissue architecture Determines speed and safety of propagation - Stephan Rohr and Jan P. Kucera
Chapter 26: Restitution, Repolarization and Alternans as Arrhythmogenic Substrate - Kenneth R. Laurita, Ph.D. and David S. Rosenbaum, M.D.
Chapter 27: Mechanoelectric Transduction/Feedback: Prevalence and Pathophysiology - Max J. Lab

PART V: MODELS OF CARDIAC EXCITATION
Chapter 28: Ionic mechanisms of cardiac electrical activity: A Theoretical Approach - Yoram Rudy
Chapter 29: Two-dimensional propagation in cardiac muscle - Bradley Roth
Chapter 30: Three-dimensional Propagation in Mathematical Models - Craig S. Henriquez, Joseph V. Tranquello, David Weinstein, Edward Hsu, Christopher R. Johnson
Chapter 31: Modeling Cardiac Defibrillation –
Natalia Trayanova

PART VI: NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY
Chapter 32: Molecular and cellular bases of β- and ą-adrenergic modulation of cardiac rhythm - Susan F. Steinberg, Richard B. Robinson, Michael R. Rosen
Chapter 33: Nerve Sprouting and Cardiac Arrhythmias. - Lan S. Chen, Peng-Sheng Chen
Chapter 34: Cholinergic Atrial Fibrillation - Leonid V. Rosenshtraukh, Vadim V. Fedorov, Oleg F. Sharifov

PART VII: NONLINEAR DYNAMICS, SPIRALS AND HEART RHYTHMS
Chapter 35: Theory of reentry - Marcel Wellner and Omer Berenfeld
Chapter 36: Nonlinear Dynamics of Excitation and Propagation in Cardiac Muscle - Zhilin Qu, Alan Garfinkel
Chapter 37: Rotors and Spiral Waves in Two Dimensions - Leslie Tung, Nenad Bursac, Felipe Aguel
Chapter 38: Scroll waves in three dimensions - Arkady M. Pertsov

PART VIII: ARRHYTHMIA MECHANISMS
Chapter 39: Electrophysiology of the Pulmonary Veins: Mechanisms of initiation of atrial fibrillation - Jeffrey E. Olgin
Chapter 40: Mechanisms of Maintenance of Atrial Fibrillation - Omer Berenfeld
Chapter 41: Electrical Remodeling and Chronic Atrial Fibrillation - David R. VanWagoner
Chapter 42: Mechanisms of Initiation of Ventricular Tachyarrhythmias - Jiashin Wu, Jianyi Wu, and Douglas P. Zipes
Chapter 43: Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Normal Hearts - José Jalife
Chapter 44: Mechanisms of ventricular fibrillation in the ischemic heart - Alexey Zaitsev
Chapter 45: Cellular mechanisms of defibrillation -
Vladimir G. Fast
Chapter 46: Global mechanisms of defibrillation - Richard A.Gray
Chapter 47: Defibrillation Waveforms - Raymond E. Ideker, Joan Huang, Gregory Walcott

PART IX: MOLECULAR GENETICS AND PHARMACOGENOMICS
Chapter 48: Mouse Models of Cardiac Arrhythmias - Barry London
Chapter 49: Human molecular Genetics and the Heart - Jeffrey A. Towbin, Neil Bowles
Chapter 50: Genetics of Long QT, Brugada and other channelopathies. - Silvia G. Priori, Ilaria Rivolta, Carlo Napolitano
Chapter 51: Pharmacogenomics of Cardiac Arrhythmias and Impact on Drug Therapy - Dan M. Roden

PART X: CLINICAL ARRHYTHMIAS MECHANISMS, FEATURES AND MANAGEMENT
SUPRAVENTRICULAR ARRHYTHMIAS

Chapter 52: Sinus rhythm abnormalities - David J. Callans and David J. Lin
Chapter 53: Atrioventricular Block And Atrioventricular Dissociation - David Schwartzman
Chapter 54: Atrial Flutter: Mechanisms, Clinical Features and Management - Albert L. Waldo
Chapter 55: Atrial tachycardia - Kenneth A. Ellenbogen and Mark A. Wood
Chapter 56: Atrial fibrillation - Stanley Nattel and Joachim R. Ehrlich
Chapter 57: Junctional Rhythms and Tachycardia - Hakan Oral and S. Adam Strickberger
Chapter 58: Atrioventricular reentry and variants - Bradley P. Knight and Fred Morady
Chapter 59: Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Reentrant Circuits - Deborah Lockwood, Kenichiro Otomo, Zulu Wang, Sara Forresti, Hiroshi Nakagawa, Karen Beckman, Benjamin J Scherlag, Eugene Patterson, Ralph Lazzara, and Warren M. Jackman
Chapter 60: Atrial arrhythmias in congenital heart disease - John K. Triedman
VENTRICULAR TACHYCARDIAS
Chapter 61: Ventricular tachycardia in patients with coronary artery disease - David J. Callans, Mark E. Josephson
Chapter 62: Ventricular Tachycardia in Patients with Dilated Cardiomyopathy - Joseph M. Galvin and Jeremy N. Ruskin
Chapter 63: Ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy - Guy Fontaine, Paul Fornes, Jean-Louis Hebert, Catherine Prost-Squarcioni, Xavier Jouven, Jean-Sebastian Hulot, Robert Frank, Daniel Thomas
Chapter 64: Ventricular tachycardia in hypertrophic cardiomyopathy - Barry J. Maron
Chapter 65: Ventricular Tachycardia In Patients With Hypertrophy And Heart Failure - Marc A. Vos, Harry J. Crijns, MD
Chapter 66: Ventricular tachycardia in patients following surgery for congenital heart disease - George F. Van Hare
Chapter 67: Brugada Syndrome - Josep Brugada, Pedro Brugada, Ramon Brugada, Charles Antzelvitch, Jeffrey Towbin
Chapter 68: Catecholaminergic Polymorphic ventricular tachycardia and short-coupled Torsades de Pointes - Carlo Napolitano and Silvia G. Priori
Chapter 69: Arrhythmias in Patients with Neurological Disorders - William J. Groh
Chapter 70: Long QT syndrome – Phenotype-Genotype Considerations - Peter J Schwartz and Silvia G Priori
Chapter 71: Long QT Syndrome – Therapeutic Considerations - Arthur J. Moss, Wojciech Zareba
Chapter 72: Ventricular tachycardia in patients with structurally normal hearts - Bruce B. Lerman, Kenneth M. Stein, Steven M. Markowitz, Suneet Mittal, Sei Iwai
Chapter 73: Bundle branch reentry - Emile Daoud
Chapter 74: Torsades De Pointes - Nabil El-Sherif and Gioia Turitto
Chapter 75: Accelerated Idioventricular Rhythm, Bi-directional Ventricular Tachycardia - Wolfram Grimm and Francis E. Marchlinski
Chapter 76: Ventricular fibrillation - Andrew Epstein
Chapter 77: Prolonged Repolarization And Sudden Infant Death Syndrome - Peter J. Schwartz and Marco Stramba - Badiale
Chapter 78: Sudden cardiac death - Robert J. Myerburg, Alberto Interian Jr., Jeffery Simmons, Agustin Castellanos

PART XI: ELECTROCARDIOGRAPHIC RECOGNITION
Chapter 79: Exit block, supernormal conduction, concealed conduction - Michael J. Kilborn and Mark A. McGuire
Chapter 80: Parasystole - Augustin Castellanos,
Nadir Saoudi, Federico Moleiro, Robert J. Myerburg
Chapter 81: Differential Diagnoisis of Wide QRS Complex Tachycardia - John M. Miller, Mithilesh K. Das, Rishi Arora, Cesar Alberte-Lista, Jianyi Wu

PART XII: DIAGNOSTIC EVALUATION
Chapter 82: Assessment of the patient with a cardiac arrhythmia - Douglas P. Zipes and William M. Miles
Chapter 83: Exercise-induced cardiac arrhythmias - Ruey Sung, Chi Tai Kuo, Wen Ter Lai
Chapter 84: Use of Long?Term (Holter) Electrocardiographic Recordings - Harold L. Kennedy
Chapter 85: Use of implantable loop recordings - Andrew Krahn, George J. Klein, Allan C. Skaines, Raymond Yee
Chapter 86: High-resolution electrocardiography - Edward J. Berbari
Chapter 87: Body surface potential mapping - Bruno Taccardi, Bonnie B. Punske, Nora Eceles Harrison
Chapter 88: Head-up tilt table testing - David G. Benditt, Cengiz Ermis, Fei Lü
Chapter 89: Heart Rate Variability and Baroreflex Sensitivity - Marek Malik
Chapter 90: Monophasic action potential recording - Michael R. Franz
Chapter 91: T wave alternans - Stefan H. Hohnloser
Chapter 92: Neurocardiac imaging - Gary D. Hutchins, Michael A. Miller and Douglas P. Zipes
Chapter 93: Mapping - Vias Markides, Oliver R. Segal, Fernando Tondato, Nicholas Peters

PART XIII: CLINICAL SYNDROMES: RECOGNITION, CLINICAL COURSE, AND MANAGEMENT
Chapter 94: Wolff-Parkinson-White Syndrome - Eric Prystowsky, Raymond Yee, George J. Klein
Chapter 95: Sinus Node Dysfunction - Michael Sweeney
Chapter 96: Syncope - Hugh Calkins
Chapter 97: Results of clinical trials on atrial fibrillation -D. George Wyse
Chapter 98: Results of clinical trials of AEDs and ICDs in Patients at Risk for Sudden Death on ventricular arrhythmias with AEDs and ICDs - Alfred Buxton

PART XIV: THERAPY
PHARMACOLOGICAL

Chapter 99: Class I antiarrhythmic drugs: quinidine, procainamide, disopyramide, lidocaine, mexiletine, flecainide, propafenone - Anne Gillis
Chapter 100: Beta-blockers and calcium channel blockers - Bramah Singh
Chapter 101: Class III Antiarrhythmiac Drugs: Amiodarone, Ibutilide and Sotalol - Timothy W. Smith, Michael E. Cain
Chapter 102: Adenosine and digoxin - John DiMarco
Chapter 103: Impact of non-traditional antiarrhythmic drugs on sudden cardiac death - Jeffrey Goldberger, Kenneth Weinberg, Alan Kadish
Chapter 104: New antiarrhythmic drugs - N A Mark Estes III
ELECTRICAL
Chapter 105: Transthoracic cardioversion and defibrillation - Richard E. Kerber
Chapter 106: Implantable cardioverter defibrillators: Technical aspects - Bruce L. Wilkoff
Chapter 107: Implantable cardioverter defibrillators: Clinical aspects - Charles Swerdlow and Kalyanam Shiukumar
Chapter 108: Implantable atrial defibrillator for atrial fibrillation - Sam Levy
Chapter 109: Implantable Pacemakers - David L. Hayes
Chapter 110: Newer Applications of Pacemakers - Michael R Gold, MD, PhD and Robert W Peters MD
Chapter 111: Biophysics and pathophysiology of lesion formation during radiofrequency catheter ablation - David E. Haines
Chapter 112: Focal catheter ablation for atrial fibrillation - Michel Haïssaguerre, Prashanthan Sanders, Pierre Jaïs, Mélèze Hocini, Dipen C. Shah, Jacques Clèmenty
Chapter 113: Pulmonary vein isolation for atrial fibrillation - Carlo Pappone and Salvatore Rosanio
Chapter 114: Catheter ablation of atrial flutter - Hans Kottkamp and Gerhara Hindricks
Chapter 115: Catheter Ablation of Atrial Tachycardia - Chin-Feng Tsai, Ching-tai Tai, Shih-Ann Chen
Chapter 116: Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia - Jonathan M. Kalman
Chapter 117: Catheter Ablation of Atrioventricular Reentry - Sabie Ernst, Feifan Ouyang, Matthias Antz, Ricardo Cappato, Karl Heinz Kuck
Chapter 118: Catheter ablation of ventricular tachycardia - William Stevenson and Kyoko Soejima
Chapter 119: Catheter ablation in pediatric patients - John D. Kugler
Chapter 120: Surgery for cardiac arrhythmias - Pierre L. Page