Cardiac Electrophysiology book cover

Cardiac Electrophysiology

From Cell to Bedside

Here's today's most authoritative and up-to-date information on basic and clinical electrophysiology. The 4th Edition covers everything from fundamental explanations of currents and channels, through the theoretical and experimental bases of cardiac electrical activity and arrhythmias, to current clinical understandings of arrhythmias and their treatment—and features the most comprehensive updating and revision to date.

Audience
Clinical Electrophysiologists; Electrophysiology Researchers, Cardiology

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Published: April 2004

Imprint: Saunders

ISBN: 978-0-7216-0323-0

Contents

  • PART I: STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION
    Chapter 1. Sodium Channels - Eduardo Marban
    Chapter 2. Cardiac Calcium Channels - Donald M. Bers
    Chapter 3. Voltage Regulated Potassium Channels -
    Gavin Y. Oudit, Rafael J. Ramirez and Peter H. Backx
    Chapter 4: Intracellular Signaling and Regulation of Cardiac Ion Channels - Anant Khositseth, David E. Clapham, and Michael J. Ackerman
    Chapter 5: Membrane Pumps and Exchangers - Larry V. Hryshko
    Chapter 6: Sarcoplasmic Reticulum Ion Channels - Gerhard Meissner.
    Chapter 7: HCN Channels: From Genes to Function -
    Andreas Ludwig, Juliane Stieber, Sven Moosmang, Stefan Herrmann, Martin Biel, Franz Hofmann
    Chapter 8: Molecular Organization and Regulation of the Cardiac Gap Junction Channel Connexin43 - Mario Delmar , Heather S. Duffy, Paul Sorgen, Steven M. Taffet, David C. Spray

    PART II: BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION
    Chapter 9: Biophysics of Normal and Abnormal Cardiac Sodium Channel Function - Jeffrey R. Balser
    Chapter 10: Gating of Cardiac Delayed Rectifier K+ Channels - Michael C. Sanguinetti and Martin Tristani-Firouzi
    Chapter 11: Heart Mechanoelectric Transduction - Frederick Sachs
    Chapter 12: Pacemaker Channels and Normal Automaticity - Dario DiFrancesco
    Chapter 13: Biophysical Properties of Inward Rectifier Potassium Channels - Justus Anumonwo
    Chapter 14: Homomeric and Heteromeric Gap Junctions - Volodya Hayrapetyan, Guoqiang Zhong, Agustín D. Martínez and Eric C. Beyer. Alonso P. Moreno

    PART III: INTERMOLECULAR INTERACTIONS AND PHARMACOLOGY OF CARDIAC ION CHANNELS
    Chapter 15: Pharmacology of the Cardiac Na Channel - Jonathan C. Makielski, Bin Ye, Timothy J. Kamp, and Craig T. January
    Chapter 16: Pharmacology of L-type and T-type channels in the heart - Xiongwen Chen and Steven R. Houser
    Chapter 17: KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease - Sheila Carrol, Junko Kurokawa, and R.S. Kass
    Chapter 18: Drug-induced Channelopathies - Charlie Antzelevitch
    Chapter 19: Prospects for Pharmacological Targeting of Gap Junction Channels - Miduturu Srinivas, Heather Duffy, Mario Delmar, David C. Spray

    PART IV: ION CHANNELS AND CELLULAR ELECTROPHYSIOLOGY
    Chapter 20: Heterogeneous expression of Potassium channels - Jeanne M. Nerbonne
    Chapter 21: Gap Junction Distribution and Regulation in the Heart - Jeffrey E. Saffitz, Deborah L. Lerner, Kathryn A. Yamada
    Chapter 22: Cellular Mechanisms of Sinoatrial Activity - Itsuo Kodama, Haruo Honjo, Halina Dobrzynski, Mark R. Boyett
    Chapter 23: Mechanisms of AV nodal Excitability and Propagation - Igor R. Efimov and Vladimir P. Nikolsk
    Chapter 24: Intercellular Communication and Impulse Propagation - André G. Kléber
    Chapter 25: Cardiac tissue architecture Determines speed and safety of propagation - Stephan Rohr and Jan P. Kucera
    Chapter 26: Restitution, Repolarization and Alternans as Arrhythmogenic Substrate - Kenneth R. Laurita, Ph.D. and David S. Rosenbaum, M.D.
    Chapter 27: Mechanoelectric Transduction/Feedback: Prevalence and Pathophysiology - Max J. Lab

    PART V: MODELS OF CARDIAC EXCITATION
    Chapter 28: Ionic mechanisms of cardiac electrical activity: A Theoretical Approach - Yoram Rudy
    Chapter 29: Two-dimensional propagation in cardiac muscle - Bradley Roth
    Chapter 30: Three-dimensional Propagation in Mathematical Models - Craig S. Henriquez, Joseph V. Tranquello, David Weinstein, Edward Hsu, Christopher R. Johnson
    Chapter 31: Modeling Cardiac Defibrillation –
    Natalia Trayanova

    PART VI: NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY
    Chapter 32: Molecular and cellular bases of β- and ą-adrenergic modulation of cardiac rhythm - Susan F. Steinberg, Richard B. Robinson, Michael R. Rosen
    Chapter 33: Nerve Sprouting and Cardiac Arrhythmias. - Lan S. Chen, Peng-Sheng Chen
    Chapter 34: Cholinergic Atrial Fibrillation - Leonid V. Rosenshtraukh, Vadim V. Fedorov, Oleg F. Sharifov

    PART VII: NONLINEAR DYNAMICS, SPIRALS AND HEART RHYTHMS
    Chapter 35: Theory of reentry - Marcel Wellner and Omer Berenfeld
    Chapter 36: Nonlinear Dynamics of Excitation and Propagation in Cardiac Muscle - Zhilin Qu, Alan Garfinkel
    Chapter 37: Rotors and Spiral Waves in Two Dimensions - Leslie Tung, Nenad Bursac, Felipe Aguel
    Chapter 38: Scroll waves in three dimensions - Arkady M. Pertsov

    PART VIII: ARRHYTHMIA MECHANISMS
    Chapter 39: Electrophysiology of the Pulmonary Veins: Mechanisms of initiation of atrial fibrillation - Jeffrey E. Olgin
    Chapter 40: Mechanisms of Maintenance of Atrial Fibrillation - Omer Berenfeld
    Chapter 41: Electrical Remodeling and Chronic Atrial Fibrillation - David R. VanWagoner
    Chapter 42: Mechanisms of Initiation of Ventricular Tachyarrhythmias - Jiashin Wu, Jianyi Wu, and Douglas P. Zipes
    Chapter 43: Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Normal Hearts - José Jalife
    Chapter 44: Mechanisms of ventricular fibrillation in the ischemic heart - Alexey Zaitsev
    Chapter 45: Cellular mechanisms of defibrillation -
    Vladimir G. Fast
    Chapter 46: Global mechanisms of defibrillation - Richard A.Gray
    Chapter 47: Defibrillation Waveforms - Raymond E. Ideker, Joan Huang, Gregory Walcott

    PART IX: MOLECULAR GENETICS AND PHARMACOGENOMICS
    Chapter 48: Mouse Models of Cardiac Arrhythmias - Barry London
    Chapter 49: Human molecular Genetics and the Heart - Jeffrey A. Towbin, Neil Bowles
    Chapter 50: Genetics of Long QT, Brugada and other channelopathies. - Silvia G. Priori, Ilaria Rivolta, Carlo Napolitano
    Chapter 51: Pharmacogenomics of Cardiac Arrhythmias and Impact on Drug Therapy - Dan M. Roden

    PART X: CLINICAL ARRHYTHMIAS MECHANISMS, FEATURES AND MANAGEMENT
    SUPRAVENTRICULAR ARRHYTHMIAS

    Chapter 52: Sinus rhythm abnormalities - David J. Callans and David J. Lin
    Chapter 53: Atrioventricular Block And Atrioventricular Dissociation - David Schwartzman
    Chapter 54: Atrial Flutter: Mechanisms, Clinical Features and Management - Albert L. Waldo
    Chapter 55: Atrial tachycardia - Kenneth A. Ellenbogen and Mark A. Wood
    Chapter 56: Atrial fibrillation - Stanley Nattel and Joachim R. Ehrlich
    Chapter 57: Junctional Rhythms and Tachycardia - Hakan Oral and S. Adam Strickberger
    Chapter 58: Atrioventricular reentry and variants - Bradley P. Knight and Fred Morady
    Chapter 59: Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Reentrant Circuits - Deborah Lockwood, Kenichiro Otomo, Zulu Wang, Sara Forresti, Hiroshi Nakagawa, Karen Beckman, Benjamin J Scherlag, Eugene Patterson, Ralph Lazzara, and Warren M. Jackman
    Chapter 60: Atrial arrhythmias in congenital heart disease - John K. Triedman
    VENTRICULAR TACHYCARDIAS
    Chapter 61: Ventricular tachycardia in patients with coronary artery disease - David J. Callans, Mark E. Josephson
    Chapter 62: Ventricular Tachycardia in Patients with Dilated Cardiomyopathy - Joseph M. Galvin and Jeremy N. Ruskin
    Chapter 63: Ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy - Guy Fontaine, Paul Fornes, Jean-Louis Hebert, Catherine Prost-Squarcioni, Xavier Jouven, Jean-Sebastian Hulot, Robert Frank, Daniel Thomas
    Chapter 64: Ventricular tachycardia in hypertrophic cardiomyopathy - Barry J. Maron
    Chapter 65: Ventricular Tachycardia In Patients With Hypertrophy And Heart Failure - Marc A. Vos, Harry J. Crijns, MD
    Chapter 66: Ventricular tachycardia in patients following surgery for congenital heart disease - George F. Van Hare
    Chapter 67: Brugada Syndrome - Josep Brugada, Pedro Brugada, Ramon Brugada, Charles Antzelvitch, Jeffrey Towbin
    Chapter 68: Catecholaminergic Polymorphic ventricular tachycardia and short-coupled Torsades de Pointes - Carlo Napolitano and Silvia G. Priori
    Chapter 69: Arrhythmias in Patients with Neurological Disorders - William J. Groh
    Chapter 70: Long QT syndrome – Phenotype-Genotype Considerations - Peter J Schwartz and Silvia G Priori
    Chapter 71: Long QT Syndrome – Therapeutic Considerations - Arthur J. Moss, Wojciech Zareba
    Chapter 72: Ventricular tachycardia in patients with structurally normal hearts - Bruce B. Lerman, Kenneth M. Stein, Steven M. Markowitz, Suneet Mittal, Sei Iwai
    Chapter 73: Bundle branch reentry - Emile Daoud
    Chapter 74: Torsades De Pointes - Nabil El-Sherif and Gioia Turitto
    Chapter 75: Accelerated Idioventricular Rhythm, Bi-directional Ventricular Tachycardia - Wolfram Grimm and Francis E. Marchlinski
    Chapter 76: Ventricular fibrillation - Andrew Epstein
    Chapter 77: Prolonged Repolarization And Sudden Infant Death Syndrome - Peter J. Schwartz and Marco Stramba - Badiale
    Chapter 78: Sudden cardiac death - Robert J. Myerburg, Alberto Interian Jr., Jeffery Simmons, Agustin Castellanos

    PART XI: ELECTROCARDIOGRAPHIC RECOGNITION
    Chapter 79: Exit block, supernormal conduction, concealed conduction - Michael J. Kilborn and Mark A. McGuire
    Chapter 80: Parasystole - Augustin Castellanos,
    Nadir Saoudi, Federico Moleiro, Robert J. Myerburg
    Chapter 81: Differential Diagnoisis of Wide QRS Complex Tachycardia - John M. Miller, Mithilesh K. Das, Rishi Arora, Cesar Alberte-Lista, Jianyi Wu

    PART XII: DIAGNOSTIC EVALUATION
    Chapter 82: Assessment of the patient with a cardiac arrhythmia - Douglas P. Zipes and William M. Miles
    Chapter 83: Exercise-induced cardiac arrhythmias - Ruey Sung, Chi Tai Kuo, Wen Ter Lai
    Chapter 84: Use of Long?Term (Holter) Electrocardiographic Recordings - Harold L. Kennedy
    Chapter 85: Use of implantable loop recordings - Andrew Krahn, George J. Klein, Allan C. Skaines, Raymond Yee
    Chapter 86: High-resolution electrocardiography - Edward J. Berbari
    Chapter 87: Body surface potential mapping - Bruno Taccardi, Bonnie B. Punske, Nora Eceles Harrison
    Chapter 88: Head-up tilt table testing - David G. Benditt, Cengiz Ermis, Fei Lü
    Chapter 89: Heart Rate Variability and Baroreflex Sensitivity - Marek Malik
    Chapter 90: Monophasic action potential recording - Michael R. Franz
    Chapter 91: T wave alternans - Stefan H. Hohnloser
    Chapter 92: Neurocardiac imaging - Gary D. Hutchins, Michael A. Miller and Douglas P. Zipes
    Chapter 93: Mapping - Vias Markides, Oliver R. Segal, Fernando Tondato, Nicholas Peters

    PART XIII: CLINICAL SYNDROMES: RECOGNITION, CLINICAL COURSE, AND MANAGEMENT
    Chapter 94: Wolff-Parkinson-White Syndrome - Eric Prystowsky, Raymond Yee, George J. Klein
    Chapter 95: Sinus Node Dysfunction - Michael Sweeney
    Chapter 96: Syncope - Hugh Calkins
    Chapter 97: Results of clinical trials on atrial fibrillation -D. George Wyse
    Chapter 98: Results of clinical trials of AEDs and ICDs in Patients at Risk for Sudden Death on ventricular arrhythmias with AEDs and ICDs - Alfred Buxton

    PART XIV: THERAPY
    PHARMACOLOGICAL

    Chapter 99: Class I antiarrhythmic drugs: quinidine, procainamide, disopyramide, lidocaine, mexiletine, flecainide, propafenone - Anne Gillis
    Chapter 100: Beta-blockers and calcium channel blockers - Bramah Singh
    Chapter 101: Class III Antiarrhythmiac Drugs: Amiodarone, Ibutilide and Sotalol - Timothy W. Smith, Michael E. Cain
    Chapter 102: Adenosine and digoxin - John DiMarco
    Chapter 103: Impact of non-traditional antiarrhythmic drugs on sudden cardiac death - Jeffrey Goldberger, Kenneth Weinberg, Alan Kadish
    Chapter 104: New antiarrhythmic drugs - N A Mark Estes III
    ELECTRICAL
    Chapter 105: Transthoracic cardioversion and defibrillation - Richard E. Kerber
    Chapter 106: Implantable cardioverter defibrillators: Technical aspects - Bruce L. Wilkoff
    Chapter 107: Implantable cardioverter defibrillators: Clinical aspects - Charles Swerdlow and Kalyanam Shiukumar
    Chapter 108: Implantable atrial defibrillator for atrial fibrillation - Sam Levy
    Chapter 109: Implantable Pacemakers - David L. Hayes
    Chapter 110: Newer Applications of Pacemakers - Michael R Gold, MD, PhD and Robert W Peters MD
    Chapter 111: Biophysics and pathophysiology of lesion formation during radiofrequency catheter ablation - David E. Haines
    Chapter 112: Focal catheter ablation for atrial fibrillation - Michel Haïssaguerre, Prashanthan Sanders, Pierre Jaïs, Mélèze Hocini, Dipen C. Shah, Jacques Clèmenty
    Chapter 113: Pulmonary vein isolation for atrial fibrillation - Carlo Pappone and Salvatore Rosanio
    Chapter 114: Catheter ablation of atrial flutter - Hans Kottkamp and Gerhara Hindricks
    Chapter 115: Catheter Ablation of Atrial Tachycardia - Chin-Feng Tsai, Ching-tai Tai, Shih-Ann Chen
    Chapter 116: Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia - Jonathan M. Kalman
    Chapter 117: Catheter Ablation of Atrioventricular Reentry - Sabie Ernst, Feifan Ouyang, Matthias Antz, Ricardo Cappato, Karl Heinz Kuck
    Chapter 118: Catheter ablation of ventricular tachycardia - William Stevenson and Kyoko Soejima
    Chapter 119: Catheter ablation in pediatric patients - John D. Kugler
    Chapter 120: Surgery for cardiac arrhythmias - Pierre L. Page

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