Cardiac Electrophysiology: From Cell to Bedside book cover

Cardiac Electrophysiology: From Cell to Bedside

Expert Consult - Online and Print

2014 BMA Medical Book Awards Highly Commended in Cardiology category!

Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies.


Hardbound, 1392 Pages

Published: October 2013

Imprint: Saunders

ISBN: 978-1-4557-2856-5


  • Part I. Structural and Molecular Bases of Ion Channel Function

    1 Voltage-Gated Sodium Channels and Electrical Excitablility of the Heart

    2 Calcium Channels in the Heart

    3 Voltage-Regulated Potassium Channels

    4 Structural and Molecular Bases of Inward Rectifier Potassium Channel Function

    5 Mammalian Calcium Pumps in Health and Disease

    6 Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function

    7 Structural and Molecular Bases of Mitochondrial Ion Channel Function

    8 Molecular Organization, Gating, and Function of Gap Junction Channels

    Part II. Biophysics of Cardiac Ion Channel Function

    9 Biophysics of Normal and Abnormal Cardiac Sodium Channel Function

    10 Regulation of Cardiac Calcium Channels

    11 KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease

    12 Structural Determinants and biophysical properties of hERG channel gating

    13 Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents

    14 Cardiac Stretch-Activated Channels and Mechano-Electric Coupling

    15 Biophysical Properties of Gap Junctions

    16 Excitation-Contraction Coupling

    Part III. Intermolecular Interactions and Cardiomyocyte Electrical Function

    17 Ion Channel Trafficking in the Heart

    18 Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5

    19 Calmodulin and CaMKII as Ca2+ switches for cardiac ion channels

    20 Macromolecular Complexes and Cardiac Potassium Channels

    21 Reciprocity of Cardiac Sodium and Potassium channels in the control of Excitability and Arrhythmias

    22 The Intercalated Disc: A Molecular Network that Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability

    23 Scaffolding Proteins and Ion Channel Diseases

    24 Epigenetics in Cardiac Rhythm Diseases

    Part IV. Cell Biology of Cardiac Impulse Initiation and Propagation

    25 Cardiac Impulse is Initiated by a Coupled System of Membrane Ion Channels and Ca2+ Cycling Proteins

    26 Biological Pacing

    27 Intercellular Communication and Impulse Propagation

    28 Mechanisms of Atrioventricular Nodal Excitability and Propagation

    29 Cell Biology of the Specialized Cardiac Conduction System

    30 Cardiac Fibroblasts and Arrhythmogenesis

    Part V. Models of Cardiac Excitation

    31 Ionic Mechanisms of Atrial Action Potentials

    32 Models of the Ventricular Action Potential in Health and Disease

    33 Calcium Signaling in a Cardiomyocyte Models with Realistic Geometries

    34 Theory of Rotors and Arrhythmias

    35 Supraventricular Arrhythmias in a Realistic 3D model of the Human Atria

    36 Cardiac Electromechanical Models

    Part VI. Neural Control of Cardiac Electrical Activity

    37 Cav1.2 and ß-Adrenergic regulation of cardiac function

    38 cholinergic and constitutive regulation of atrial potassium channel

    39 Pulomnary vein ganglia and the neural regulation of the heart rate

    40 Neural activity and atrial tachyarrhythmias

    41 Sympathetic Innervation, Denervation, and cardiac arrhythmias

    Part VII. Arrhythmia Mechanisms

    42 Dominant Frequency and the Mechanisms of Initiation and Maintenance of Atrial fibrillation

    43 Rotors in Human Atrial Fibrillation

    44 atrial ischemia and fibrillation

    45 The Molecular pathophysiology of atrial fibrillation

    46 Myofibroblasts, Cytokines and Persistent Atrial Fibrillation

    47 Role of The Autonomic Nervous System In Atrial Fibrillation

    48 Mechanisms of ventricular tachycardia and fibrillation

    Part VIII. Molecular Genetics and Pharmacogenomics

    49 Genetics of Atrial Fibrillation

    50 Mechanisms in Heritable Sodium Channel Diseases

    51 Inheritable Potassium Channel Disease

    52 Genetics and Cellular Mechanisms of the J Wave Syndromes

    53 Inheritable Phenotypes Associated with Altered Intracellular Calcium Regulation

    Part IX. Pharmacologic, Genetic and Cell Therapy of Ion Channel Dysfunction

    54 Pharmacologic Bases of Antiarrhythmic Therapy

    55 Pharmacogenomics of Cardiac Arrhythmias

    56 Optogenetic Control of Heart Muscle

    57 Cell Therapy and Regeneartive Electrophysiology

    Part X. Diagnostic Evaluation

    58 Assessment of the Patient with a Cardiac Arrhythmia

    59 Differential Diagnosis of Narrow and Wide Complex Tachycardias

    60 Mapping and Navigation

    61 CT and MR Imaging for Electrophysiology

    62 Intracardiac Echocardiography for Electrophysiology

    63 Exercise -Induced Arrhythmias

    64 Cardiac Monitoring: Short- and Long-Term Recording

    65 Electrocardiographic Imaging in Patients with Acute Coronary Syndrome

    66 Head-up Tilt Table Testing

    67 Autonomic Testing and Cardiac Risk

    68 Monophasic Action Potential Recording

    69 T-Wave Alternans

    70 Noninvasive Electrocardiographic Imaging of Human Ventricular Arrhythmias and Electrophysiologic Substrate

    71 Genetic Testing

    Part XI. Supraventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management

    72 Sinus Node Abnormalities

    73 Atrial Tachycardia

    74 Typical and Atypical Atrial Flutter: Mapping and Ablation

    75 Atrial Fibrillation: Paroxysmal, Persistent, and Permanent

    76 Preexcitation, Atrioventricular Reentry, and Variants

    77 Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Reentrant Circuits

    78 Atrial Arrhythmias in Adults With Congenital Heart Disease

    79 Junctional Tachycardia

    Part XII. Ventricular Tacharrhythmias: Mechanisms, Clinical Features, and Management

    80 Premature Ventricular Complexes

    81 Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management

    82 Fascicular Ventricular Arrhythmias

    83 Bundle Branch Reentry Tachycardia

    84 Ischemic Heart Disease

    85 Ventricular Tachycardia in Patients with Dilated Cardiomyopathy

    86 Ventricular Arrhythmias in Hypertrophic Cardiomyopathy

    87 Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

    88 VTs in Catecholaminergic Cardiomyopathy (Catecholaminergic Polymorphic Ventricular Tachycardia)

    89 Ventricular Arrhythmias in Heart Failure

    90 Ventricular Tachycardia in Noncompaction Cardiomyopathy

    91 Ventricular Arrhythmias in Takatsubo Cardiomyopathy

    92 Brugada Syndrome 1992-2012: Twenty Years of Scientific Progress

    93 Long and Short QT Syndromes

    94 Andersen-Tawil Syndrome

    95 Timothy Syndrome

    96 J Wave Syndromes

    97 Idiopathic Ventricular Fibrillation

    98 Sudden Infant Death Syndrome

    99 Sudden Cardiac Death in Adults

    100 Arrhythmias in Patients with Neurologic Disorders

    101 Drug-Induced Ventricular Tachycardia

    102 Ventricular Arrhythmias in Congenital Heart Disease

    Part XIII. Syncope and AV Block

    103 Syncope

    104 Postural Orthostatic Tachycardia Syndrome

    105 Progressive Conduction System Disease

    106 Atrioventricular Block

    Part XIV. Arrhythmias in Special Populations

    107 Sex Differences in Arrhythmias

    108 Sudden Cardiac Deaths in Athletes, Including Commotio Cordis

    109 Arrhythmias in Pediatric Population

    110 Sleep-Disordered Breathing and Arrhythmias

    Part XV. Pharmocologic Therapy

    111 Standard Antiarrhythmic Drugs

    112 New Antiarrhythmic Drugs and New Concepts for Old Drugs

    113 Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death

    114 Prevention of Stroke with Atrial Fibrillaiton

    Part XVI. Electrical Therapy

    115 Implantable Cardioverter Defibrillators: Technical Aspects

    116 Implantable Cardioverter Defibrillators: Clinical Aspects

    117 Implantable Pacemakers

    118 Cardiac Resynchronization Therapy

    119 Newer Applications of Pacemakers

    120 Catheter Ablation: Technical Aspects

    121 Catheter Ablation: Clinical Aspects

    122 Ablation for Atrial Fibrillation

    123 Ablation of Supraventricular Tachyarrhythmias

    124 Catheter Ablation for Ventricular Tachycardia in Patients with Structural Heart Disease

    125 Special Ablation Approaches: Epicardial, Other

    126 Ablation in Pediatrics

    127 Catheter Ablation in Congenital Heart Disease

    Part XVII. Surgery for Arrhythmias

    128 Atrial Fibrillation and Other SVTs

    129 Surgery for Ventricular Arrhythmias

    Part XVIII. New Approaches

    130 Vagal Stimulation for Heart Failure

    131 Spinal Cord Stimulation for Heart Failure and Arrhythmias

    132 Left Atrial Occluders/Isolation


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