Brain Lipids in Synaptic Function and Neurological Disease book cover

Brain Lipids in Synaptic Function and Neurological Disease

Clues to Innovative Therapeutic Strategies for Brain Disorders

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.

Hardbound, 400 Pages

Published: September 2015

Imprint: Academic Press

ISBN: 978-0-12-800111-0

Contents

  • Part I. Brain Lipids

    Chapter 1. Chemical basis of lipid biochemistry

    Chapter 2. Brain membranes  

    Chapter 3. Lipid metabolism and oxidation in neurons and glial cells

    Chapter 4. Variations of brain lipid content

    Part II. Brain Lipids and Synaptic Functions

    Chapter 5. A molecular view of the synapse

    Chapter 6. Lipid-protein interactions in the brain

    Chapter 7. Lipid regulation of receptor function

    Part III. Brain Lipids and Neurodegenerative Disease

    Chapter 8. Common mechanisms in neurodegenerative disease

    Chapter 9. Creutzfeldt-Jakob’s disease

    Chapter 10. Parkinson’s disease

    Chapter 11. Alzheimer’s disease

    Part IV. Brain Pathogens and Amyloidogenic Proteins: The Lipid Connection

    Chapter 12. Viral and bacterial diseases

    Chapter 13. A unifying theory

    Conclusion

    Glossary

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