This series presents first hand accounts of industrial and academic research projects in medicinal chemistry. The overriding purpose is representation of the many organic chemical facets of drug discovery and development. This would include: de novo drug design, organic chemical synthesis, spectroscopic studies, process development and engineering, structure-activity relationships, chemically based drug mechanisms of action, the chemistry of drug metabolism, and drug physical-organic chemistry.Volumes 1-3 were published by JAI Press under the editorship of Bruce E. Maryanoff and Cynthia A. Maryanoff, R.W. Johnson Pharmaceutical Research Institute. Volume 4 was published by JAI Press under the editorship of Bruce E. Maryanoff and Allen B. Reitz, R.W. Johnson Pharmaceutical Research Institute. This series has been discontinued and combined with Progress in Medicinal Chemistry.