Advances in DNA Sequence-Specific Agents

Series Editor:

  • Graham Jones, Northeastern University, Department of Chemistry, Boston, MA, USA

DNA sequence specificity plays a critical role in a number of biological processes, and influences a diverse range of molecular recognition phenomena, including protein-DNA, oligomer-DNA, and ligand -DNA interactions. This series is intended to give the reader an up-to-date view of both established and emergent trends, in research involving DNA-interactive agents with an emphasis on sequence specificity. The series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. Recent topics that have been addressed include the mechanisms of selective DNA-topoisomerase poisoning by anti tumor agents, sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates, DNA-cleaving anti tumor chromoproteins, application of sequence-specific anti sense and anti-gene therapy in oncology, and mimetics of the DNA structure. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interactions are likely to play an increasingly important role. Key developments are likely to involve small molecules with highly specific groove binding, molecules with affinity for unique DNA micro environments, oligonucleotides capable of stabilizing unique DNA architectures, macromolecules which form unique ternary complexes, and molecules which influence the recruitment and assembly of transcription factors. Accordingly, manuscripts have been solicited from experts covering a diverse range of scientific backgrounds, reflecting the cross-disciplinary and dynamic nature of the series.

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