Bone Substitute Biomaterials

Edited by

  • K. Mallick, Formerly associate professor of the Warrick Manufacturing Group at Warwick University, UK

Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration.

Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms.

View full description


Bone Substitute Biomaterials provides a detailed review of this important area, and will be a helpful resource for scientists and engineers in both academia and the biomedical industry. It should be of particular interest to those working in orthopaedics and dentistry.


Book information

  • Published: July 2014
  • Imprint: Woodhead Publishing
  • ISBN: 978-0-85709-497-1

Table of Contents



Part 1 Properties of bone substitute biomaterials in medicine

1 Bone substitutes based on biomineralization
S. Sprio, M. Sandri, S. Panseri, M. Iafisco, A. Ruffini, S. Minardi, A. Tampieri, Institute of Science and Technology for Ceramics, Italy

2 Experimental quantification of bone mechanics
P. Bhattacharya and G. H. van Lenthe, KU Leuven - University of Leuven, Belgium

3 Osteoinductivization of dental implants and bone-defect-filling materials
E. B. Hunziker, University of Bern, Switzerland  

4 Bioresorbable bone graft substitutes
T. J. Blokhuis, University Medical Center Utrecht, the Netherlands

Part 2 Biomaterial substitute scaffolds and implants for bone repair

5(19) Multi-functional scaffolds for bone regeneration
V. Guarino, M. G. Raucci, A. Ronca, V. Cirillo and L. Ambrosio, National Research Council, IMCB and DSCTM, Italy

6 3D bioceramic foams for bone tissue engineering
K. K. Mallick and J. Winnett, University of Warwick, UK

7 Titanium and NiTi foams for bone replacement
A. Bansiddhi, Kasetsart University, Thailand and D. C. Dunand, Northwestern University, USA

8 Bioceramics for skeletal bone regeneration
G. C. Wang, Z. F. Lu and H. Zreiqat, The University of Sydney, Australia

Part 3 Biomaterials for bone repair and regeneration

9 Cartilage grafts for bone repair and regeneration
C. S. Bahney and R. S. Marcucio, University of California, USA

10 Chitosan for bone repair and regeneration
J. Venkatesan and S. K. Kim, Pukyong National University, Republic of Korea 

11 Inorganic polymer composites for bone regeneration and repair
L. Grøndahl. K. S. Jack, and. C. S. Goonasekera, The University of Queensland, Australia

12 Marine organisms for bone repair and regeneration
S. A. Clarke and P. Walsh Queen’s University Belfast, UK