Bone Disease of Organ Transplantation

Edited by

  • Juliet Compston, Univeristy of Cambridge, United Kingdom
  • Elizabeth Shane, Columbia University, New York, New York, USA

Bone disease, particularly osteoporosis, has emerged as a common and serious complication of solid organ transplantation. In recent years there have been real advances in our understanding of the pathogenesis and pathophysiology of bone loss, however treatment studies have been relatively sparse and successful strategies to reduce skeletal morbidity after transplantation remain to be clearly established. This book provides a unique resource for the many health professionals involved with transplantation of bone disease, both in terms of its scientific background and the management of the disease in clinical practice.
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Clinicians who work with organ transplantation, as well as researchers in the fields of bone biology and tissue engineering.


Book information

  • Published: December 2004
  • ISBN: 978-0-12-183502-6


te:"...a useful and needed review for those involved in the investigation or management of transplant-related bone disease."
Matt J. Koch MD, Washington University School of Medicine for Doodys

Table of Contents

Part I. Basic Transplantation and Bone Biology1. Principles of Transplantation Immunology2. Bone Biology: Bone Structure and Remodeling3. Skeletal Effects of Glucocorticoids: Basic and Clinical Aspects4. Transplantation Bone Disease Induced by Non-Steroid Immunosuppressants5. Molecular Effects of Calcineurin Inhibitors6. Bone and Immune SystemPart II. Pathogenesis of Transplantation-Related Bone Disease7. Fracture Prevalence and Incidence in Solid Organ Transplant Recipients8. Bone Histomorphometry and Its Application to Transplantation Bone Disease9. The Role of Parathyroid Hormone in the Evolution of Bone Loss After Organ Transplantation10. The Role of Hypogonadism in the Evolution of Bone Loss Before and After Cardiac Transplantation11. Pathogenesis of Transplantation Bone Diseases: A Unifying HypothesisPart III. Clinical Features of Transplantation Bone Disease12. Bone Disease After Kidney Transplantation13. Histologic Abnormalities of Bone Before and After Kidney Transplantation14. Bone Disease Following Kidney-Pancreas and Pancreas Transplantation15. Bone Disease After Liver Transplantation16. Bone Disease in Patients Before and After Cardiac Transplantation17. Bone Loss in Patients Before and After Lung Transplantation18. Transplantation for Cystic Fibrosis: Effect on the Skeleton19. Bone Diseaes After Bone Marrow Transplantation20. Osteonecrosis and Organ Transplantation21. Pediatric Transplant Bone DiseasePart IV. Management22. Management of Bone Disease in Candidates for Organ Transplant23. Management: Prevention of Bone Loss After Organ Transplantation24. Management: Established Osteoporosis in Organ Transplant Receipients