Bone Cancer book cover

Bone Cancer

Progression and Therapeutic Approaches

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.

Bone biologists, cancer researchers, oncologists, orthopedic surgeons, radiologists and other specialists in cancer imaging; Medical libraries; graduate academic libraries.


Published: September 2009

Imprint: Academic Press

ISBN: 978-0-12-374895-9


  • "...Presents a comprehensive, translational source for all aspects of bone cancer in one reference work…Clear presentation...of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches."--Anticancer Research, February 2015

    "Reviewing the current advances in the progression and therapeutic approaches to bone cancer is an extremely challenging task. Bone cancer is not a single disease; rather, it is a field comprising a diverse and complex range of malignancies, from primary bone tumors of stromal cell origin, to hematopoietic malignancies and secondary metastatic bone disease. Dominique Heymann has assembled an exciting, comprehensive and up-to-date series of reviews contributed by experts in the basic and clinical aspects of bone research. In the past decade, our understanding of cancers involving bone has increased tremendously, underpinned by advances in the cellular, molecular and biochemical mechanisms of bone cell interactions in health and disease, together with advances in genetics, diagnostics, imaging and therapeutic strategies. All these aspects are covered in this timely volume, which will galvanize further cooperative efforts in the coming years between basic researchers, oncologists and pathologists towards understanding the causes of different bone cancers and translating this knowledge into the clinic."

    -- Agi E. Grigoriadis, PhD, Departments of Craniofacial Development and Orthodontics, King's College London, United Kingdom

    "Our understanding of bone biology and diseases has strikingly progressed in the last decade. In parallel, the processes that lead to various forms of cancer have been further unraveled and the mechanisms leading to metastatic spread further explored. In this book, Dr. Heymann has gathered some of the world experts on these subjects to explore the cutting edge where these fields merge in the context of bone cancer and metastasis, their pathophysiology, diagnosis and treatment. This encompassing book will undoubtedly meet the needs of residents and fellows as well as expert clinicians and scientists."

    --Roland Baron, Professor, Harvard Medical School, Boston MA, USA



  • Section 1: Genetic Control, Frequencies and Epidemiology of Bone Caner

    1. Epidemiology of Primary Bone Tumors and Economical Aspects of Bone Metastases

    Esther I. Hauben and Pancras C.W. Hogendoorn

    Section 2: Bone Microenvironment and Bone Cancer

    2. Tumor-Bone Cell Interactions in Bone Metastases

    Pierrick G.J. Fournier, Lauren K. Dunn, Gregory A. Clines, Theresa A. Guise

    3. Early Bone Metastasis-Associated Molecular and Cellular Events

    Philippe Clezardin

    4. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and Parathyroid Hormone Signaling Pathways

    Julia Billiard, John A. Robinson, Ramesh A. Bhat, Bheem M. Bhat, Richard Murrills and Peter V.N. Bodine

    5. Osteoclast Differentiation and Function

    Luis Filgueira

    6. Immunoregulation of Osteoclast Differentiation in Multiple Myeloma Bone Diseases

    Maria Grano, Giacomina Brunetti and Silvia Colucci

    7. Facts and Hypothesis on Osteolytic Lesions Related to Normal and Tumoral Epithelial Dental Cell Differentiation

    Blandine Ruhin, Frederic Lezot, Aymann Bouattour, Sonia Ghoul-Mazghar, Ariane Berdal, Vianney Descroix

    8. The Role of the Interleukin-6 Family of Cytokines in Bone Remodeling and Bone Cancer

    Frederic Blanchard, Emmanuelle David, Bénédicte Brounais

    9. Proteases and Therapeutic Approaches of Bone Tumors

    Velasco C. Ruiz, Y. Fortun, Dominique Heymann, Marc Padrines

    Section 3: and Bone Markers of Cancer (genes and proteins)

    10.Bone Remodelling Markers and Bone Cancer

    Markus J. Seibel

    11. Cytogenetic and Molecular Genetic Alterations in Bone Tumors

    Suvi Savola, Tom Böhling, Sakari Knuutila

    12. Cytogenetic of Bone Tumors

    Jiyun Lee, Mallory Martin, Shibo Li

    13. Genetic Aspects of Bone Tumors

    Shamini Selvarajah, Maria Zielenska, Jeremy A. Squire, Paul Park

    14. Proteomic of Bone Cancers

    Stephanie Byrum, Eric Siegel, Sudeepa Bhattacharyya, Larry J Suva

    15. Gene and proteomic profiling of osteosarcoma

    Tsz-Kwong Man, Pulivarthi H. Rao, Ching C. Lau

    16. Molecular Pathology of Osteosarcoma

    Walter C. Bell, Gene P. Siegal


    Section 4: Histopathology of Primary Bone Tumors and Bone Metastases

    17. Technical Aspects: How Do We Best Prepare Bone Samples for Proper Histological Analysis?

    Daniel Chappard

    18. Osteoclast-Rich Lesions of Bone: A Clinical and Molecular Overview

    Adrienne Flanagan, Roberto Tirabosco, Panagiotis D. Gikas

    19. Recent Advances in Biology of Bone Tumors and New Diagnostic Tools

    Gonzague de Pinieux, Corinne Bouvier

    20. Ewing Sarcoma Family of Tumors

    Joseph D. Khoury

    21. The Histopathology of Skeletal Metastases

    David G. Hicks, Ping Tang


    Section 5: Imaging of Bone Cancer

    22. Interventional Radiologic Techniques and their Contribution of the Management of Bone Tumors

    Robert G. Jones, Eric J. Heffernan, Faisal Rashid, Peter L. Munk

    23. Imaging of Bone Metastases

    Nieroshan Rajaurbendra, Nathan Lawrentschuk

    24. Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers

    Holger Schirrmeister, Coskun Arslandemir


    Section 6: Pain Control in Bone Cancer

    25. Pain Control with Palliative Radiotherapy in Bone Metastases

    Alysa Fairchild, Amanda Hird, Edward Chow

    26. Mechanisms and Management of Bone Cancer Pain

    Mary Ann C. Sabino, Denis R. Clohisy

    27. Malignant Skeletal Pain: Mechanisms and Potential Therapeutic Opportunities Monica Herrera, Juan Miguel Jimenez-Andrade, Marina Vardanyan,

    Patrick Mantyh


    Section 8: New Therapeutic Advance in Primary Bone Cancers and Bone Metastases

    28. Animal Models of Malignant Primary Bone Tumors and Novel Therapeutic Approaches

    Julie Rousseau, François Lamoureux, Gaelle Picarda, François Gouin, Valérie Trichet, Françoise Rédini

    29. In Vivo Models Used in Studies of Bone Metastases

    Ingunn Holen, Michele A. Lawson

    30. Cytokine Gene Therapy in Bone Remodeling

    Carl Richards, David Smyth

    31. Non-Surgical Treatment of Chondrosarcoma: Current Concepts and Future Perspectives

    Eric L. Staals, Emanuela Palmerini, Stefano Ferrari, and Mario Mercuri

    32. Mechanistic Role of RANKL in Cancer Induced Bone Diseases and Development of Targeted Therapy to Inhibit this Pathway

    William C. Dougall

    33. Chondrosarcoma of Bone: Diagnosis and Therapy

    Arne Steitbueger, Jendrik Hardes, Georg Gosheger

    34. Current Status of Immunotherapy for Osteosarcoma and its Future Trends

    Kanji Mori, Kosei Ando, Yoshitaka Matsusue, Dominique Heymann

    35. Bisphosphonates, Bone Health and the Clinical Biology of Bone Metastases from Breast Cancer

    Alexander Paterson

    36. A Multi-Targeted Approach to Treating Bone Metastases

    Robert D. Loberg, Kenneth J. Pienta

    37. Bone Metasteses of Prostatic Cancer: Pathophysiology, Clinical Complications, Actual Treatment and Future Directions

    Sara De Dosso, Fernanda G. Herrera, Dominik R. Berthold

    38. Apoptosis and Drug Resistance in Malignant Bone Tumors

    Udo Kontny


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