Biotechnology and Safety Assessment book cover

Biotechnology and Safety Assessment

A comprehensive treatise on new developments in biotechnology, the authors of Biotechnology and Safety Assessment, 3e, bring readers an up-to-date review of food safety issues, pre-clinical safety and development of new foods and drugs, plant biotechnology, food allergies and safety assessment, and consumer benefits with regard to genetically modified food.Tomorrow's foods will be obtained from genetically modified crops, offering consumers higher nutritional value and more of it. Our medications will be obtained through a variety of biotechnological procedures yielding more potent and specific medications for diseases and vaccines. In order to make this view of the future come to light, John A. Thomas and Roy L. Fuchs have updated their classic in order to keep readers one step ahead.Written by internationally recognized molecular biologists, plant agronomists, microbiologists, toxicologists, nutritionists, and regulatory authorities, this third edition is an excellent and authoritative resource, making it a valuable resource to any biomedical library or scientific bookshelf.

Audience
Toxicologists, phamacologists, regulatory agency professionals, environmental scientists, and agricultural scientists.

Hardbound, 400 Pages

Published: July 2002

Imprint: Academic Press

ISBN: 978-0-12-688721-1

Reviews

  • "This book is a valuable update for those wishing to keep abreast of the potential of food biotechnology and also to construct safety evaluation and assurance programs for the derived food products." -TRENDS IN FOOD SCIENCE & TECHNOLOGY (May 2003) "The book is a treasure trove of useful information...Thomas and Fuchs provide a useful, fact-filled handbook of biotechnology biosafety data. ...If you have only one source of biosafety data, this is for you." —NATURE BIOTECHNOLOGY (October 2002) "...should be of interest to toxicologists, pharmacologists, nutritionists, and those responsible for assessing risk/benefits, environmental impact and safety of GM products." —SCITECH BOOK NEWS(December 2002)

Contents


  • Contributors

    Preface

    Chapter 1. Using Plant Biotechnology to Reduce Allergens in Food: Status and Future Potential

    Introduction

    Characteristics of Food Allergens

    Traditional Plant Breeding Methods for Reducing Allergenicity

    Use of Genetic Engineering to Reduce Allergenic Potential

    Concluding Remarks

    References

    Chapter 2. Experience with Biosafety Research and Postmarket Environmental Monitoring in Risk Management of Crops Derived from Plant Biotechnology

    Introduction

    End Points and Definitions

    Regulatory Aspects

    Biosafety Research on Virus-Resistant Sugar Beet

    Using Biogeographical Data for Biosafety Research

    Monitoring of Insect-Resistant Maize

    Concluding Remarks: Linking Biosafety Research and Monitoring

    References

    Chapter 3. Safety Assessment of Foods and Food Ingredients Produced by Genetically Modified Microorganisms

    Introduction

    Issues in Food and Food Ingredients Produced From rDNA

    Concepts in Safety Testing

    Regulatory Requirements

    Case Studies in Safety Assessment

    Concluding Remarks

    References

    Chapter 4. Food Safety Assessment of Current and Future Plant Biotechnology Products

    Introduction

    Safety Evaluation and the Substantial Equivalence Paradigm

    How are Genetically Modified Foods Evaluated for Food Safety?

    Future Trends in Food Safety Assessments

    Concluding Remarks and Future Prospects

    References

    Chapter 5. Plant Biotechnology Products with Direct Consumer Benefits

    Introduction

    Improved Nutritional Qualities

    Products with Enhanced Quality Traits

    Concluding Remarks

    References

    Chapter 6. Animal Feeds from Crops Derived through Biotechnology: Farm Animal Performance and Safety

    Introduction

    Crops Fed to Farm Animals in the United States

    Characteristics of Intake and Digestion by Farm Animals

    Performance, Health, and Nutrient Utilization for Farm Animals Consuming Biotechnology-Derived Crops

    Composition of Meat, Milk, and Eggs from Farm Animals Consuming Biotechnology-Derived Crops

    Detecting Plant Source Proteins and DNA in Animal Products

    Concluding Remarks: Future Directions

    References

    Chapter 7. Preclinical Immunotoxicology Assessment of Cytokine Therapeutics

    Introduction

    Cytokines and Their Role in Health and Disease

    Modulation of Cytokine Activity as a Therapeutic Modality

    Clinical Toxicity Associated with Modulation of Cytokine Activity

    Immunotoxicolcogy Assessment of Cytokine Therapeutics

    Concluding Remarks

    References

    Chapter 8. Ecological Assessment of Crops Derived through Biotechnology

    Introduction

    Terminology

    Ecological Risk Assessment Principles

    Ecological Risk Assessment Principles for Genetically Modified Plants

    Concluding Remarks

    References

    Chapter 9. Ribozyme Technology and Drug Development

    Introduction

    Nonenzymatic Antisense Oligonucleotides as Inhibitors of Specific Gene Expression

    RNA-based Enzymes

    Catalytic DNAs

    Therapeutic Applications of Catalytic Oligonucleotides

    Ribozyme Delivery, Pharmacokinetics, and Metabolism

    Concluding Remarks: Future Prospects

    References

    Chapter 10. Biotherapeutics: Current Status and Future Directions

    Introduction

    Recombinant Proteins: Approved for Clinical Use

    Interferon Alfa

    Recombinant Proteins in Clinical Development

    Natural Biological Response Modifiers

    Chemically Defined Biological Response Modifiers

    Combination Chemotherapy, Immunotherapy, and Cellular Therapy

    Concluding Remarks

    References

    Chapter 11. Food Allergy Assessment for Products Derived through Plant Biotechnology

    Introduction to Food Allergies and Allergens

    Novel Proteins: Justification for Allergenicity Assessment

    Allergy Assessment in the Gene Discovery Phase

    Decision Tree Approach: The 2001 FAO/WHO Decision Tree

    Example Applications of Allergenicity Assessment

    Concluding Remarks

    References

    Chapter 12. Biotechnology: Safety Evaluation of Biotherapeutics and Agribiotechnology Products

    Introduction

    Biotherapeutics

    Agribiotechnology

    Concluding Remarks

    References

    Chapter 13. The Potential of Plant Biotechnology for Developing Countries

    Introduction

    Agriculture in Africa

    African Crops and their Problems

    Vaccines for Africa

    Genetically Modified Crops in South Africa

    Genetically Modified Crops in Developing Countries

    The Anti-GMO Lobby and Developing Countries

    Future Directions

    Concluding Remarks

    References

    Chapter 14. Preclinical Safety Evaluation of Vaccines

    Introduction

    Regulatory Framework

    Outline of the Proposed Studies

    Concluding Remarks

    References

    Chapter 15. Gene Flow from Transgenic Plants

    Introduction

    Initial Hybrid Formation

    Transgene Introgression

    Transgene Spread

    Concluding Remarks

    References

    Chapter 16. Safety Assessment of Insect-Protected Cotton

    Introduction

    Molecular Characterization of Bollgard Cotton

    Cry1Ac and NPT II Protein Levels in Bollgard Cotton Plants

    Safety Assessment of the Cry1Ac and NPT II Proteins in Bollgard Cotton

    Compositional Analysis and Nutritional Assessment of Bollgard Cotton

    Horizontal Gene Transfer and the Assessment of Marker Genes

    Environmental Assessment

    Concluding Remarks

    References






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