Bioprocess Engineering Principles


  • Pauline Doran, Ph.D., Swinburne University of Technology, Faculty of Science, Engineering and Technology, School of Science, Department of Chemistry and Biotechnology

This welcome new edition covers bioprocess engineering principles for the reader with a limited engineering background. It explains process analysis from an engineering point of view, using worked examples and problems that relate to biological systems. Application of engineering concepts is illustrated in areas of modern biotechnology such as recombinant protein production, bioremediation, biofuels, drug development, and tissue engineering, as well as microbial fermentation. The main sub-disciplines within the engineering curriculum are all covered; Material and Energy Balances, Transport Processes, Reactions and Reactor Engineering. With new and expanded material, Doran’s textbook remains the book of choice for students seeking to move into bioprocess engineering.


  • All chapters thoroughly revised for current developments, with over 200 pgs of new material, including significant new content in:
    • Metabolic Engineering
    • Sustainable Bioprocessing
    • Membrane Filtration
    • Turbulence and Impeller Design
    • Downstream Processing
    • Oxygen Transfer Systems

  • Over 150 new problems and worked examples
  • More than 100 new illustrations

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(a) Senior undergraduate students in applied biology, biomedical engineering, or chemical engineering taking final year options in bioprocessing/biotechnology (b) industrial practitioners working in biotechnology, pharmaceutical companies, food industries, and those trained in molecular biology and cell manipulation, who need to acquire knowledge on the principles of large scale processing of biological material.


Book information

  • Published: March 2012
  • ISBN: 978-0-12-220851-5


"Doran (Swinburne U. of Technology, Australia) revises her 1995 graduate and undergraduate textbook for students of molecular biology, biotechnology, and related disciples who have little or no engineering background but want to become familiar with the processes by which biological discoveries are transformed into commercial products. Her emphasis is on the underlying scientific and engineering principles rather than on specific biotechnology applications, she says, so most of the material in the first edition remains relevant. There have been some significant developments, however, and she includes new sections on sustainable bioprocessing and metabolic engineering. Overall, she covers introductory matters, material and energy balances, physical processes, and reactions and reactors."--Reference & Research Book News October 2012

Table of Contents

  1. Bioprocess Development: An Interdisciplinary Challenge
  2. Introduction to Engineering Calculations
  3. Presentation and Analysis of Data
  4. Materials Balances
  5. Energy Balances
  6. Unsteady-State Material and Energy Balances
  7. Fluid Flow
  8. Mixing
  9. Heat Transfer
  10. Mass Transfer
  11. Unit Operations
  12. Homogeneous Reactions
  13. Heterogeneous Reactions
  14. Reactor Engineering

Appendix A - Conversion Factors
Appendix B - Ideal Gas Constant
Appendix C - Physical and Chemical Property Data
Appendix D - Steam Tables
Appendix E - Mathematical Rules
Appendix F - U.S. Sieve and Tyler Standard Screen Series