Biomedical Information Technology

Edited by

  • David Feng, Biomedical & Multimedia Information Technology (BMIT) Research Group, School of Information Technologies, University of Sydney, and Centre for Multimedia Signal Processing, Department of Electronic & Information Engineering, Hong Kong Polytechnic University

The enormous growth in the field of biotechnology necessitates the utilization of information technology for the management, flow and organization of data. The field continues to evolve with the development of new applications to fit the needs of the biomedicine. From molecular imaging to healthcare knowledge management, the storage, access and analysis of data contributes significantly to biomedical research and practice. All biomedical professionals can benefit from a greater understanding of how data can be efficiently managed and utilized through data compression, modelling, processing, registration, visualization, communication, and large-scale biological computing. In addition the book contains practical integrated clinical applications for disease detection, diagnosis, surgery, therapy, and biomedical knowledge discovery, including the latest advances in the field, such as ubiquitous M-Health systems and molecular imaging applications.
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biomedical and clinical engineers; physicians and surgeons; health physicists; bioinformaticists; biomedical researchers, students, educators; members of the basic science community; IT specialists, healthcare professionals and researchers.


Book information

  • Published: August 2007
  • ISBN: 978-0-12-373583-6

Table of Contents

Section I: Technological FundamentalsChapter 1 Medical ImagingDr. Xiaofeng Zhang, Dr. Nadine Smith and Prof. Andrew Webb1.1 Introduction1.2 Digital radiography1.3 Computed tomography1.4 Nuclear medicine1.5 Ultrasonic imaging1.6 Magnetic resonance imaging1.7 Diffuse optical imaging1.8 Biosignals1.9 Appendix1.10 Exercises1.11 Bibliography1.12 IndexChapter 2 Electronic Medical Record (EMR)Dr. Eugene,Y. S. Lim, Prof. Michael Fulham and Prof. David Dagan Feng2.1 Introduction2.2 Medical data and patient record2.3 Terminology standards – vocabulary and a clinical coding system12.4 Information exchange standards2.5 Usability issues in EMR2.6 User interface2.7 Evaluation2.8 EMR system – a case study: a web-based imaging electronic patient history2.9 Summary2.10 Exercise2.11 Bibliography and references2.12 IndexChapter 3 Image Data Compression and StorageProf. Hong Ren Wu, Dr. Damian M. Tan, Dr. Tom Weidong Cai and Prof. David Dagan Feng 3.1 Introduction3.2 Picture compression3.3 Compression in the dicom standard3.4 Data compression for dynamic functional images3.5 Summary3.6 Exercises3.7 References3.8 IndexChapter 4 Content-Based Medical Image RetrievalDr. Tom Weidong Cai, Dr. Jinman Kim and Prof. David Dagan Feng4.1 Introduction4.2 CBMIR by physical visual features4.3 CBMIR by geometric spatial features4.4 CBMIR by combination of semantic and visual features4.5 CBMIR by physiological functional features4.6 Summary4.7 Exercises4.8 Bibliography and references4.9 IndexChapter 5 Data Modeling and SimulationDr. Alessandra Bertoldo, Prof. Claudio Cobelli5.1 Introduction5.2 Compartmental models5.3 Model identification5.4 Model validation5.5 Simulation5.6 Case study5.7 Quantification of medical images5.8 Exercises5.9 Bibliography and referencesChapter 6 Techniques for Parametric ImagingProf. David Dagan Feng, Dr. Lingfeng Wen and Dr. Stefan Eberl6.1 Introduction6.2 Parametric image estimation methods6.3 Noninvasive methods6.4 Clinical applications of parametric images6.5 Summary6.6 Exercise6.7 Bibliography and references6.8 IndexChapter 7 Data Processing and AnalysisProf. Chris Wyatt, Prof. Yu-Ping Wang, Prof. Matthew T. Freedman, Prof. Murray Loew and Prof. Yue Wang7.1 Introduction7.2 Medical image enhancement7.3 Medical image segmentation7.4 Medical image feature extraction7.5 Medical image interpretation7.6 Summary7.7 Exercises7.8 Bibliography7.9 IndexChapter 8 Data Registration and FusionDr. Xiu Ying Wang, Dr. Stefan Eberl, Prof. Michael Fulham, Dr. Seu Som and Prof. David Dagan Feng8.1 Introduction8.2 Fundamentals of biomedical image registration and fusion8.3 Feature-based medical image registration8.4 Intensity-based registration8.5 Hybrid registration and hierarchical registration8.6 Hardware registration8.7 Assessment of registration accuracy8.8 Applications of biomedical image registration and fusion8.9 Summary8.10 Exercises8.11 Bibliography and references8.12 IndexChapter 9 Data Visualization and DisplayDr. Jinman Kim, Dr. Tom Weidong Cai, Prof. Michael Fulham, Dr. Stefan Eberl and Prof. David Dagan Feng9.1 Introduction9.2 Two-Dimensional (2D) visualization techniques9.3 Three-Dimensional (3D) visualization techniques9.4 Volume navigation interface9.5 Volume enhancement and manipulation9.6 Large data visualization and optimization9.7 Dual-modality PET/CT visualization9.8 Data display devices9.9 Applications of biomedical visualization9.10 Summary9.11 Exercises9.12 Bibliography and references9.13 IndexChapter 10 Data Communication and Network InfrastructueProf. Doan B. Hoang and Dr. Andrew J. Simmonds10.1 Introduction10.2 Transmission and communication technologies10.3 The internet and World Wide Web10.4 Wireless and mobile technologies in m-health10.5 Sensor networks for health monitoring10.6 Applications of wireless technologies in telemedicine10.7 Summary10.8 Exercises10.9 Bibliography and references10.10 IndexChapter 11 Data Security and Protection for Medical ImagesDr. Eugene, Y. S. Lim 11.1 Introduction11.2 Overview of cryptographic system11.3 Digital watermarking11.4 Medical image watermarking11.5 Region-based reversible watermarking for secure pet image management11.6 Summary11.7 Exercise11.8 Bibliography11.8 IndexChapter 12 Biological ComputingProf. Eric P Hoffman, Erica Reeves, Dr. Yetrib Hathout, Dr. Zuyi Wang and Josephine Chen12.1 Introduction12.2 Overview of genomic methods12.3 Overview of proteomic methods12.4 Bioinformatics and information infrastructure12.5 Data mining and large-scale biological databases12.6 Biological event-driven, time-driven and hybrid simulation techniques12.7 Summary12.8 Bibliography Section II: Integrated ApplicationsChapter 13 PACS and Medical Imaging Informatics (MII) for Filmless HospitalsProf. Brent J. Liu and Prof. H.K. Huang13.1 Introduction13.2 PACS infrastructure13.3 PACS components and workflow13.4 PACS controller and image archive13.5 Large-scale PACS implementation13.6 PACS clinical experiences13.7 Summary13.8 Exercises13.9 Bibliography and references13.9 IndexChapter 14 KMeX: A Knowledge-Based Digital Library for Retrieving Scenario-Specific Medical Text DocumentsProf. Wesley W. Chu, Dr. Zhenyu Liu, Dr. Wenlei Mao and Dr. Qinghua Zou14.1 Introduction14.2 Extracting key concepts from documents14.3 Transforming similar queries into query templates14.4 Topic-oriented directory14.5 Phrase-based vector space model for automatic document retrieval14.6 Knowledge-based scenario-specific query expansion14.7 A system architecture for retrieving scenario-specific free text documents14.8 Summary14.9 Exercises14.10 BibliographyChapter 15 Integrated Multimedia Patient Record SystemsDr. Ruth E. Dayhoff, Mr. Peter M. Kuzmak and Mr. Kevin Meldrum15.1 Introduction15.2 Multimedia patient record15.3 Multimedia patient record system architecture components15.4 Electronic medical chart components15.5 Objects comprising the multimedia patient record15.6 Capturing multimedia data at the source15.7 DICOM image acquisition15.8 Remote data and image viewing across the healthcare network15.9 Impact on patient care15.10 Summary15.11 ReferencesChapter 16 Computer-Aided Diagnosis (CAD)Prof. Maryellen L. Giger and Dr. Kenji Suzuki16.1 Introduction16.2 CAD16.3 CAD for cancer screening16.4 CAD for differential diagnosis16.5 Intelligent CAD workstations – indices of similarity and human/computer interfaces16.6 Summary16.7 Exercises16.8 Bibliography16.9 IndexChapter 17 Clinical Decision Support Systems (CDSS)Dr. Peter Weller, Dr. Abdul Roudsari and Prof. Ewart Carson17.1 Introduction17.2 Overview of CDSS17.3 Human diagnostic reasoning17.4 A structure for characterising CDSS17.5 Decision support tools17.6 Decision support systems in the hospital and other healthcare settings17.7 Healthcare education applications17.8 Verification, validation and evaluation17.9 Summary17.10 Exercises17.11 References17.12 IndexChapter 18 Medical Robotics and Computer-Integrated Interventional MedicineProf. Russell H. Taylor and Dr. Peter Kazanzides18.1 Introduction18.2 Technology & Techniques18.3 Surgical CAD/CAM18.4 Surgical Assistance18.5 Summary and conclusion18.6 Exercises18.7 References18.8 IndexChapter 19 Functional Techniques for Brain Magnetic Resonance ImagingDr. Sirong Chen, Dr. Kai-Ming Au Yeung and Dr. Gladys Goh Lo19.1 Introduction19.2 Diffusion-weighted MR imaging in brain19.3 MR perfusion imaging in brain19.4 Functional MRI (fMRI) using bold techniques19.5 Clinical MR spectroscopy in brain19.6 Summary19.7 Exercises19.8 Bibliography and references19.9 IndexChapter 20 Molecular Imaging in CancerProf. Kristine Glunde, Dr. Catherine A. Foss and Prof. Zaver M. Bhujwalla 20.1 Introduction20.2 Imaging of gene expression20.3 Receptor imaging20.4 Enzyme-activated probes20.5 Metabolic imaging20.6 Imaging of permeability, perfusion, and blood flow20.7 Imaging of the tumor microenvironment20.8 Multimodality imaging20.9 Conclusion20.10 Exercises20.11 References20.12 IndexChapter 21 Molecular Imaging in Biology and PharmacologyProf. Sung-Cheng Huang, Prof. Anna M. Wu and Prof. Jorge R. Barrio21.1 Introduction and background21.2 Considerations for quantitative molecular imaging21.3 Design/development of molecular imaging probes21.4 Molecular imaging of beta-amyloid and NFT21.5 Molecular imaging using antibody probes21.6 Some other molecular imaging applications21.7 Summary and future perspectives21.8 Exercises21.9 References21.10 IndexChapter 22 From Telemedicine to Ubiquitous M-Health: the Evolution of E Health SystemsDr. Dejan Raškoviæ, Dr. Aleksandar Milenkoviæ, Prof. Piet C. De Groen andDr. Emil Jovanov22.1 Introduction22.2 Overview of m-health systems22.3 M-health based on Wireless Body Area Networks (WBAN)22.4 Wireless intelligent sensors for m-health22.5 Wireless mobile devices for m-health22.6 Next-generation m-health systems22.7 Summary22.8 Exercises22.9 References22.10 IndexChapter 23 Multimedia for Future Health – Smart Medical Home………………1Dr. Jinman Kim, Dr. Zhiyong Wang, Dr. Tom Weidong Cai and Prof. David Dagan Feng23.1 Introduction23.2 Multimedia for human-computer interaction23.3 Multimedia content management23.4 Multimedia delivery23.5 Smart medical home23.6 Telemedicine in the smart medical home23.7 Sensory devices and health monitoring23.8 Speech recognition and conversational systems23.9 Multimedia technologies for patient education and care23.10 Multimedia operating theater and Virtual Reality (VR)23.11 Summary23.12 Exercises23.13 References23.15 Index